Melia Granath-Panelo

Mitochondrial control of fuel switching via carnitine biosynthesis

Christopher Auger, Hiroshi Nishida, Bo Yuan, Guilherme Martins Silva et autres

Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthesis from trimethyllysine (TML) is essential, particularly for those who consume plant-based diets; however, its molecular regulation and …

us (code pays fourni par la source)

Mitochondrial control of fuel switching via carnitine biosynthesis

Christopher Auger, Hiroshi Nishida, Bo Yuan, Guilherme Martins Silva et autres

Metabolic adaptation to environmental changes, such as fasting and cold exposure, involves a dynamic shift in fuel utilization from glucose to fatty acid oxidation, a process that relies on carnitine-mediated fatty acid oxidation in mitochondria. While dietary sources of animal origin (e.g., …

us (code pays fourni par la source)

Mitochondrial heterogeneity and adaptations to cellular needs

Melia Granath-Panelo, Shingo Kajimura

us (code pays fourni par la source)

BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis

Anthony R.P. Verkerke, Dandan Wang, Naofumi Yoshida, Zachary H. Taxin et autres

Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT thermogenesis is tightly associated with increased energy expenditure, reduced body weight, and improved glucose homeostasis. However, human BAT is protective against type 2 diabetes, independent of body …

us, jp (code pays fourni par la source)

On the cutting edge: perspectives in bioenergetics

Melia Granath-Panelo, Anna Krook, Jared P. Rutter, Shingo Kajimura

us, se (code pays fourni par la source)