Ricardo Martínez‐Murillo

Artificial Intelligence Pipeline for Mammography-Based Breast Cancer Detection: An Integrated Systematic Review and Large-Scale Experimental Validation

Daniel Añez, Giuseppe Conti, Juan Jose Uriarte, José Javier Serrano Olmedo et autres

Background and Objectives: Breast cancer remains a leading cause of cancer-related morbidity and mortality worldwide, and robust, interpretable artificial intelligence (AI) pipelines are increasingly being explored to support mammography-based detection. This study combines a PRISMA 2020-compliant systematic review with an original experimental …

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Effect of Photothermal Therapy Using Gold Nanoparticles Conjugated with Hyaluronic Acid in an Intracranial Murine Glioblastoma Model

Javier Domingo-Diez, Alice Foti, Óscar Casanova-Carvajal, Lorena Marrodán et autres

Purpose: Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor. Conventional treatments for GBM include surgery, chemotherapy, radiotherapy, or a combination of these. However, emerging therapies, such as hyperthermia treatments, are being developed. One of these new therapies is …

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The brain in Spain: The legacy of Santiago Ramón y Cajal

Emmanuel Drouin, Ricardo Martínez‐Murillo, Patrick Hautecœur

The legacy of Santiago Ramón y Cajal, Spain's first Nobel laureate neuroscientist recognized as the founding father of modern neuroscience, is to be preserved in a new museum in Madrid: the National Museum of Natural Sciences (MNCN), one of the most important …

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Mesenchymal Stem Cells from Fat: From Differentiation Mechanisms to Biomedical Application in Patients

Jose Joaquín Merino, María Gabriela Villalba, Ricardo Martínez‐Murillo, Ana I. Flores

Adipose tissue mesenchymal stem cells (AD-MSC or ADSC) are multipotent cells that do not show immune rejection. In this work, we analyze the route of administration and its possible differentiation into specific lineages of adipogenic, chondrogenic, osteogenic, myogenic, or neurogenic phenotypes. Transplanted …

UNRAVELLING BRI2 EXPRESSION AND PROCESSING DURING NEURONAL DIFFERENTIATION

Mariana Vassal, Filipa Martins, Руслана Савчук, Fátima Camões et autres

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The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy

Emelina R. Rodríguez-Ruiz, Raquel Herrero-Labrador, Ana P. Fernández-Fernández, Julia Serrano-Masa et autres

Great effort has been devoted to the synthesis of novel multi-target directed tacrine derivatives in the search of new treatments for Alzheimer’s disease (AD). Herein we describe the proof of concept of MBA121, a compound designed as a tacrine–ferulic acid hybrid, and …

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Preclinical examination of early‐onset thalamic‐cortical seizures after hemispheric stroke

Pablo García‐Peña, Milagros Ramos, Juan Manuel López, Ricardo Martínez‐Murillo et autres

OBJECTIVE: Ischemic stroke is one of the main causes of death and disability worldwide and currently has limited treatment options. Electroencephalography (EEG) signals are significantly affected in stroke patients during the acute stage. In this study, we preclinically characterized the brain electrical …

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Neuroprotective and antioxidant properties of new quinolylnitrones in in vitro and in vivo cerebral ischemia models

Beatriz Chamorro, Sara Izquierdo-Bermejo, Julia Serrano, Dimitra Hadjipavlou‐Litina et autres

Abstract Cerebral ischemia is a condition affecting an increasing number of people worldwide, and the main cause of disability. Current research focuses on the search for neuroprotective drugs for its treatment, based on the molecular targets involved in the ischemic cascade. Nitrones …

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8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

Damijan Knez, Daniel Diez‐Iriepa, Mourad Chioua, Andrea Gottinger et autres

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weight nitrone, that is readily synthesized from commercially …

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Database from Preclinical Examination of Early-Onset Thalamic–Cortical Seizures after Hemispheric Stroke

Pablo García‐Peña, Milagros Ramos, Juan Manuel López, Ricardo Martínez‐Murillo et autres

The data files below show intracranial electroencephalography (iEEG) recordings from left hemisphere of adult CD-1 mice days before (basal, B) and after (post-stroke, P) by middle cerebral artery occlusion (infartion in the right hemisphere). The recording settings are as follows: Recording software: …

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Database from Preclinical Examination of Early-Onset Thalamic–Cortical Seizures after Hemispheric Stroke

Pablo García‐Peña, Milagros Ramos, Juan Manuel López, Ricardo Martínez‐Murillo et autres

The data files below show intracranial electroencephalography (iEEG) recordings from left hemisphere of adult CD-1 mice days before (basal, B) and after (post-stroke, P) by middle cerebral artery occlusion (infartion in the right hemisphere). The recording settings are as follows: Recording software: …

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Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

Rocío Fernández-Serra, Emma Martínez‐Alonso, Alberto Alcázar, Mourad Chioua et autres

Brain stroke is a highly prevalent pathology and a main cause of disability among older adults. If not promptly treated with recanalization therapies, primary and secondary mechanisms of injury contribute to an increase in the lesion, enhancing neurological deficits. Targeting excitotoxicity and …

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