Alexander Damanakis

Complications After Rectal Cancer Surgery: Do Female Patients Fare Better? A Retrospective, Matched Cohort Analysis

Alexander Damanakis, Georg Dieplinger, Angela Ernst, Patricia Wyzlic et autres

BACKGROUND: Rectal cancer is one of the most common cancers in the Western world. The path toward personalized treatments in medicine includes further determination of sex-associated differences. OBJECTIVE: The objective of this study is to explore sex-related differences in the outcome of …

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The effect of bile swap, bile stent and antibiotic therapy on postoperative outcome in pancreatic head resections

Patricia Wyzlic, Alexander Damanakis, Lars M. Schiffmann, Nikolai Schleußner et autres

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Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms

Alexander Damanakis, Kevin T Jamouss, Abigail C. Cornwell, Martine Jongepier et autres

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Spatial profiling of human pancreatic ductal adenocarcinoma reveals molecular alterations associated with venous invasion

Alexander T.F. Bell, Peter Chianchiano, Katsuya Hirose, Daniel James Salas-Escabillas et autres

In pancreatic ductal adenocarcinoma (PDAC), venous invasion (VI) is a critical step in metastasis and is associated with poor survival. However, little is known about the molecular features of VI. To investigate, we performed spatial transcriptomic analysis of 95 human PDAC tissue …

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Risk factors for postoperative complications after Ivor-Lewis esophagectomy

I Kreutzer, A. Abu Hejleh, Naita M. Wirsik, Alexander Damanakis et autres

Background and Aims: Ivor-Lewis esophagectomy remains one of the most complex oncologic procedures with overall postoperative complications of around 60%. Over one third of all patients suffer from complications that require at least endoscopic or other interventional therapy even in high volume …

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The transcription factor AP-1 as a treatment option for patients with colorectal adenocarcinoma

Nikolai Schleußner, Christian Goddemeier, D Puhleva, Ella Leugner et autres

Background: The Activator Protein-1 (AP-1) transcription factors are expressed in many cancer entities and are correlated to deregulated transcription factor networks including dedifferentiation and therapy resistance. They are involved in key functions of the cellular biology and maintain and adjust the transcriptional …

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First safety analysis of an open-label, single arm phase II trial investigating the efficacy, safety and quality of life of neoadjuvant chemotherapy with liposomal irinotecan combined with oxaliplatin and 5-fluoruracil/folinic acid followed by curative surgical resection in patients with hepatic oligometastatic adenocarcinoma of the pancreas (HOLIPANC).

Dirk Waldschmidt, Nam Gyu Im, Alexander Damanakis, Thomas Schmidt et autres

4172 Background: Aim of the prospective single arm HOLIPANC trial (NCT04617457) is to evaluate the efficacy and safety of multimodal treatment in pancreatic oligometastatic disease. Methods: Patients with hepatic oligometastatic pancreatic cancer receive up to 8 cycles of a combination of liposomal …

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Vascularity of the gastric conduit predicts complications after Ivor-Lewis esophagectomy

Julian Lemties, Carolin Scheidt, Jin‐On Jung, Naita M. Wirsik et autres

BACKGROUND: Anastomotic leakage (AL) contributes to postoperative morbidity and mortality after Ivor-Lewis esophagectomy. Vascular high-risk patients show a significantly increased risk of AL. We previously showed that laparoscopic ischemic conditioning (ISCON) of the stomach prior esophagectomy in these high-risk patients is a …

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Stellenwert der Chirurgie bei Oligometastasierung gastrointestinaler Malignome

Alexander Damanakis, Hans F. Fuchs, Christoph Kahlert, Thomas Schmidt

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Stellenwert der Schnellschnittdiagnostik in der Pankreaschirurgie

Patricia Wyzlic, Alexander Damanakis, Alexander Quaas, Christiane J. Bruns et autres

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Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms

Kevin T Jamouss, Alexander Damanakis, Abigail C. Cornwell, Martine Jongepier et autres

Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to late-stage diagnoses. To improve patient outcomes, early intervention in precursor lesions such as intraductal papillary mucinous neoplasm (IPMN) is crucial. However, early intervention must be balanced against overtreatment of low-risk lesions that …

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Impact of structured surveillance of patients with esophageal cancer following surgical resection with curative intent

Friederike Baehr, Johanna Teloh-Benger, Alexander Damanakis, Florian Gebauer et autres

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