Yen‐Lin Liu

A Phase Ib Case Series Using Bortezomib With Chemotherapy in Atypical Teratoid/Rhabdoid Tumors

Wan‐Ling Ho, Ming‐Yun Hsieh, Yu‐Mei Liao, Shyh‐Shin Chiou et autres

BACKGROUND: Atypical teratoid/rhabdoid tumors (ATRTs) are aggressive pediatric brain tumors that are sensitive to proteasome inhibitors in preclinical models. We evaluated the feasibility of combining the proteasome inhibitor, bortezomib, with chemotherapy. METHODS: /day on days 1, 4, 8, and 11 of a …

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Surgical resection and targeted therapy in a pediatric NTRK-rearranged low-grade spindle cell sarcoma: a case report

Chien‐Kai Wang, Yen‐Lin Liu, Wan‐Ling Ho, Shu‐Mei Chen

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Robust assessment of early MRD levels could further improve treatment outcomes in low-risk patients of pediatric acute lymphoblastic leukemia: The Report of Taiwan Pediatric Oncology Group (TPOG)-ALL Study

Hsi‐Che Liu, Shiann‐Tarng Jou, Shih‐Hsiang Chen, Tang‐Her Jaing et autres

Abstract Treatment modification, including but not limited to deintensifcation, for pediatric acute lymphoblastic leukemia (ALL) without compromising treatment outcomes remains a major issue for low-risk patients. Taiwan Pediatric Oncology Group (TPOG)-ALL-2002 study demonstrated that two courses of reinduction therapy provided no additional …

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Real-world factor VIII trough levels of severe-type people with Hemophilia A (PwHA) on efanesoctocog alfa prophylaxis: Interpersonal variation, clinical correlates and predictors

Chia-Yau Chang, Shiue‐Wei Lai, Der-Shiun Wang, Jia-Ruey Tsai et autres

Abstract Introduction: Efanesoctocog alfa (EA) is a high-sustained FVIII, designed to decouple FVIII from endogenous von Willebrand factor (VWF). Its half life breaks through the ceiling of VWF half life, achieving to 48 hours in adults in phase 3 EXTEN-1 trial, and …

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Surgical Resection and Targeted Therapy in a Pediatric NTRK-Rearranged Low- Grade Spindle Cell Sarcoma: A Case Report

Chien‐Kai Wang, Shu‐Mei Chen, Yen‐Lin Liu

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A consensus on the diagnosis and management of neurofibromatosis type 1 in Taiwan

I‐Jun Chou, Pi‐Chuan Fan, Chieh‐Tsai Wu, Tu-Hsueh Yeh et autres

Neurofibromatosis type 1 (NF1) is a genetic disorder resulting from pathogenic variants in the tumor suppressor NF1 gene, which encodes neurofibromin. Its clinical manifestations are age-related and affect multiple systems, ranging from the characteristic café-au-lait macules, visible on the skin from birth, …

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Neurofibromatosis Type 1 : A General Review

Hsin‐Lun Lee, Yen‐Lin Liu, Tai‐Tong Wong

Neurofibromatosis type 1 (NF1) is an autosomal-dominant genetic disorder caused by pathogenic variants in the NF1 gene. Its clinical phenotype is heterogeneous and evolves across the lifespan; approximately 1 in 3000 individuals worldwide are affected. Cardinal features comprise café-au-lait macules, axillary/inguinal freckling, …

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Morphometric and radiomics analysis toward the prediction of epilepsy associated with supratentorial low-grade glioma in children

Min‐Lan Tsai, Kevin Li‐Chun Hsieh, Yen‐Lin Liu, Yi-Shan Yang et autres

OBJECTIVES: Understanding the impact of epilepsy on pediatric brain tumors is crucial to diagnostic precision and optimal treatment selection. This study investigated MRI radiomics features, tumor location, voxel-based morphometry (VBM) for gray matter density, and tumor volumetry to differentiate between children with …

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Synergistic Drug Combination Screening Using a Nanodroplet Processing Platform to Enhance Neuroblastoma Treatment in TH-MYCN Transgenic Mice

Hsinyu Lee, Yen‐Tzu Liao, Zhi‐Kai Yu, Yi‐Xun Huang et autres

Neuroblastoma is a highly aggressive pediatric cancer with a poor prognosis, particularly in high-risk cases characterized by MYCN amplification. The severe side effects associated with high-dose chemotherapy further complicate treatment. Despite significant advancements in drug screening, traditional platforms remain limited due to …

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Synergistic drug combination screening using a nanodroplet processing platform to enhance neuroblastoma treatment in TH ‐ MYCN transgenic mice

Yen‐Tzu Liao, Zhi‐Kai Yu, Yi‐Xun Huang, Kuan‐Hung Lin et autres

Neuroblastoma is a highly aggressive pediatric cancer with a poor prognosis, particularly in high-risk (HR) cases characterized by MYCN amplification. The severe side effects associated with high-dose chemotherapy further complicate treatment. Despite significant advancements in drug screening, traditional platforms remain limited due …

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Supplementary Table S2 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions

Audrey‐Anne Lamoureux, Michael J. Fisher, Lauriane Lemelle, Elke Pfaff et autres

Supplementary Table S2. Responses based on clinical assessment for each line of therapy. Non-targeted therapy and TRKi given concurrently in a specific line were excluded.

Supplementary Table S3 from Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions

Audrey‐Anne Lamoureux, Michael J. Fisher, Lauriane Lemelle, Elke Pfaff et autres

Supplementary Table S3. Survival outcome.