Fabrice Lalloué

New proteomic signature in circulating extracellular vesicles from tumor-draining and peripheral veins of patients with lung adenocarcinoma

Jérémy Tricard, Stéphanie Durand, Amandine Rovini, Amy Gateau et autres

BACKGROUND: The identification of noninvasive prognostic biomarkers for monitoring relapse in patients with locally advanced lung cancer remains a primary objective. Tumor-draining vein (TDV) plasma samples are known to be enriched in cancer biomarkers compared to peripheral vein (PV) samples and may …

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Proof of Concept for Tumor Mutational Burden Prediction Through Biophysical Analysis Based on UHF-Dielectrophoresis

Héloïse Daverat, Nina Blasco, Sandrine Robert, Amandine Rovini et autres

Tumor Mutational Burden (TMB) is a critical biomarker used to determine patient eligibility for immunotherapy with immune checkpoint inhibitors. However, its gold-standard assessment via whole exome sequencing is limited by high costs, technical complexity, and lengthy processing times. To address these challenges, …

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Sortilin exhibits tumor suppressor-like activity by limiting EGFR transduction function

Eric Lapeyronnie, Camille Granet, J. Tricard, F. Gallet et autres

Lung cancer is the leading cause of cancer deaths worldwide and remains one of the most difficult to cure. Tyrosine kinase receptors, such as the epidermal growth factor receptor (EGFR), are often aberrantly activated by gene mutation and drive tumor growth. Monotherapy …

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Ultra-High-Frequency-Dielectrophoresis Microfluidic Biosensor to Detect the Transformation Potential of Extracellular Vesicles Derived from Cancer Stem Cells

Elodie Barthout, Élisa Lambert, Stéphanie Durand, Céline Hervieu et autres

Cancer stem cells (CSCs) remain challenging to isolate and characterize because of their plastic phenotype. To overcome this issue, we used a microfluidic lab-on-a-chip analysis approach based on ultra-high frequency dielectophoresis (UHF-DEP) to measure the dielectrophoretic signature of colorectal cancer cells. We …

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New proteomic signature in circulating extracellular vesicles from tumor-draining and peripheral veins of patients with lung adenocarcinoma

Jérémy Tricard, Stéphanie Durand, Amandine Rovini, Amy Gateau et autres

fr, ca (code pays fourni par la source)

Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer

Béatrice Demoures, Fabienne Soulet, Jean Descarpentrie, Isabel Galeano-Otero et autres

The adipokine apelin has been directly implicated in various physiological processes during embryogenesis and human cancers. Nevertheless, the importance of the conversion of its precursor proapelin to mature apelin in tumorigenesis remains unknown. In this study, we identify Furin as the cellular …

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Effet des vésicules extracellulaires circulantes issues de patients atteints de polyarthrite rhumatoïde et traités par inhibiteur de JAK : impact sur le développement d’un cancer du poumon in vitro ?

T. Loupret, Hussein Akil, Pascale Vergne‐Salle, Fabrice Lalloué

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Predicting Tumor Mutational Burden from UHF-Dielectrophoresis Crossover Frequency

Héloïse Daverat, Nina Blasco, Sandrine Robert, Arnaud Pothier et autres

ABSTRACT Tumor Mutational Burden (TMB) has emerged as a crucial biomarker to guide patient eligibility for immunotherapy. However, whole exome sequencing, the gold-standard method for TMB measurement, remains limited in accessibility due to its high costs, operational complexity, and lengthy processing times. …

fr (code pays fourni par la source)

New proteomic signature in circulating extracellular vesicles from tumor-draining vein of lung adenocarcinomas patients

Jérémy Tricard, Stéphanie Durand, Amy Gateau, Luc Négroni et autres

ABSTRACT Identification of noninvasive prognostic biomarkers, allowing monitoring of frequently developed relapse in patients with locally advanced non-small cell lung cancer (NSCLC), still of primary importance. Tumor-draining vein (TDV) plasma samples, are known to be enriched in circulating cancer biomarkers compared to …

fr, ca (code pays fourni par la source)

Comparison of methods for cancer stem cell detection in prognosis of early stages NSCLC

Boutaîna Chandouri, May Yassine, I.A. Lea, Jérémy Tricard et autres

BACKGROUND: Despite advances in diagnosis and treatment in lung cancer, therapies still fail to improve patient management due to resistance mechanisms and relapses. As Cancer stem cells (CSCs) directly contribute to tumor growth and therapeutic resistance, their clinical detection represents a major …

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Sedimentation field-flow fractionation for rapid phenotypic antimicrobial susceptibility testing: a pilot study

Audrey Gauthier, Linda Tlili, Serge Battu, Coline Le Moan et autres

BACKGROUND: The increase in antibiotic resistance is a major public health issue. The development of rapid antimicrobial susceptibility testing (AST) methods is becoming a priority to ensure early and appropriate antibiotic therapy. OBJECTIVES: To evaluate sedimentation field-flow fractionation (SdFFF) as a method …

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Sedimentation Field-Flow Fractionation: A Diagnostic Tool for Rapid Antimicrobial Susceptibility Testing

Audrey Gauthier, Linda Tlili, Serge Battu, Sylvie Delebassée et autres

Conventional antimicrobial susceptibility testing (AST) methods require 24–48 h to provide results, creating the need for a probabilistic antibiotic therapy that increases the risk of antibiotic resistance emergence. Consequently, the development of rapid AST methods has become a priority. Over the past …

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