Philippa C. Griffin

Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial

David Stephen Lawrence, Charles Waithaka Muthoga, David B. Meya, Lillian Tugume et autres

BACKGROUND: HIV-associated cryptococcal meningitis is a leading cause of AIDS-related mortality. The AMBITION-cm trial showed that a regimen based on a single high dose of liposomal amphotericin B deoxycholate (AmBisome group) was non-inferior to the WHO-recommended treatment of seven daily doses of …

gb, Botswana, us, Ouganda, Malawi, Afrique du Sud, Zimbabwe, fr (code pays fourni par la source)

Phylogenomic analyses of the genusDrosophilareveals genomic signals of climate adaptation

Fang Li, Rahul Rane, Victor Luria, Zijun Xiong et autres

Many Drosophila species differ widely in their distributions and climate niches, making them excellent subjects for evolutionary genomic studies. Here, we have developed a database of high-quality assemblies for 46 Drosophila species and one closely related Zaprionus. Fifteen of the genomes were …

cn, dk, au, us, es (code pays fourni par la source)

Application of a bioinformatics training delivery method for reaching dispersed and distant trainees

Christina R. Hall, Philippa C. Griffin, Andrew J. Lonie, Jeffrey H. Christiansen

Many initiatives have addressed the global need to upskill biologists in bioinformatics tools and techniques. Australia is not unique in its requirement for such training, but due to its large size and relatively small and geographically dispersed population, Australia faces specific challenges. …

au (code pays fourni par la source)

Genome Annotation Infrastructure Roadmap for Australia

Tiffanie Maree Nelson, Philippa C. Griffin, Jeffrey H. Christiansen

This document summarises genome annotation tools and methodologies, how the Australian life science research community currently undertakes this work as well as common data-, software- or compute-related infrastructure challenges faced by that community when using current approaches (information obtained through consultation with …

us (code pays fourni par la source)

Testing the environmental warming responses of Brachyscome daisy species using a common garden approach

Megan J. Hirst, Philippa C. Griffin, Li‐Hsin Wu, Ary A. Hoffmann

Abstract As temperatures increase in a warming world, there will be different responses among related plant species, with some species able to increase growth rate under warmer conditions and others less likely. Here, we identify survival and growth parameters in a group …

au (code pays fourni par la source)

A Re-Evaluation of Chironomid Deformities as an Environmental Stress Response: Avoiding Survivorship Bias and Testing Noncontaminant Biological Factors

Bryant S. Gagliardi, Sara M. Long, Vincent J. Pettigrove, Philippa C. Griffin et autres

Larval deformities have been observed in chironomids, and are thought to be associated with aquatic contaminant exposure. However, in laboratory assays, deformities have not been linked with contaminants in the absence of potential confounding variables including mortality, which introduces a survivorship bias. …

au (code pays fourni par la source)

Tracking genetic invasions: Genome‐wide single nucleotide polymorphisms reveal the source of pyrethroid‐resistant Aedes aegypti (yellow fever mosquito) incursions at international ports

Thomas L. Schmidt, Anthony R. J. van Rooyen, Jessica Chung, Nancy M. Endersby‐Harshman et autres

Abstract Biological invasions are increasing globally in number and extent despite efforts to restrict their spread. Knowledge of incursion pathways is necessary to prevent new invasions and to design effective biosecurity protocols at source and recipient locations. This study uses genome‐wide single …

au (code pays fourni par la source)

Genomic changes associated with adaptation to arid environments in cactophilic Drosophila species

Rahul Rane, Stephen L. Pearce, Fang Li, Chris W. Coppin et autres

BACKGROUND: Insights into the genetic capacities of species to adapt to future climate change can be gained by using comparative genomic and transcriptomic data to reconstruct the genetic changes associated with such adaptations in the past. Here we investigate the genetic changes …

au, cn, dk (code pays fourni par la source)

Tracking genetic invasions: genome-wide SNPs reveal the source of pyrethroid-resistant Aedes aegypti (yellow fever mosquito) incursions at international ports

Thomas L. Schmidt, Anthony R. J. van Rooyen, Jessica Chung, Nancy M. Endersby‐Harshman et autres

Abstract Biological invasions are increasing globally in number and extent despite efforts to restrict their spread. Knowledge of incursion pathways is necessary to prevent new invasions and to design effective biosecurity protocols at source and recipient locations. This study uses genome-wide single-nucleotide …

au, us (code pays fourni par la source)

A Wolbachia infection from Drosophila that causes cytoplasmic incompatibility despite low prevalence and densities in males

Kelly M. Richardson, Philippa C. Griffin, Siu Fai Lee, Perran Albert Ross et autres

au (code pays fourni par la source)

Peer Review Report For: Best practice data life cycle approaches for the life sciences [version 2; peer review: 2 approved]

Philippa C. Griffin, Jyoti Khadake, Kate S. Lemay, Suzanna Lewis et autres

Throughout history, the life sciences have been revolutionised by technological advances; in our era this is manifested by advances in instrumentation for data generation, and consequently researchers now routinely handle large amounts of heterogeneous data in digital formats. The simultaneous transitions towards …

au, gb, us (code pays fourni par la source)

Best practice data life cycle approaches for the life sciences

Philippa C. Griffin, Jyoti R. Khadake, Kate S. Lemay, Suzanna Lewis et autres

Throughout history, the life sciences have been revolutionised by technological advances; in our era this is manifested by advances in instrumentation for data generation, and consequently researchers now routinely handle large amounts of heterogeneous data in digital formats. The simultaneous transitions towards …

au, gb, us (code pays fourni par la source)