Edgardo Moreno

Investigations on infections caused by new Brucella species in neotropical forests

Anne Keriel, Théo Pastre, Betty Rouaisnel, Jean‐Philippe Lavigne et autres

Brucella amazoniensis is a recently discovered species represented by several isolates from humans (French Guiana, Brazil and USA) and a cow (Texas, USA). Most human cases had close contact with local wildlife; our current hypothesis is thus that some of these animals …

Brucella intergenic-OME: Genomic characterization of intergenic regions unveiling structural similarities and differences within chromosomes and Brucella species

Ana Mariel Zúñiga-Pereira, Marcela Súarez-Esquivel, Edgardo Moreno, Carlos Chacón Diaz

Brucella species exhibit a high level of genomic similarity, with whole-genome compar- isons revealing 97-99% identity among species. Despite this genetic homogeneity, distinct differences in host preference, virulence and zoonotic potential contribute to the unique infection outcome of each species. Intergenic regions, …

Pathogenicity of Brucella sp. ST27 Kogia sima Isolates in Murine and Cell Models

Andrea Romero-Magaña, Carlos Chacón-Díaz, Alejandro Alfaro-Alarcón, Marcela Suárez-Esquivel et autres

Members of the genus Brucella are bacterial pathogens of global importance, and their increasing detection in marine mammals has raised concerns for wildlife conservation and public health. In this study, we evaluated the biological and pathogenic characteristics of two Brucella sp. sequence …

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Diagnostic Performance of Rose Bengal, Competitive ELISA, and Native Hapten (NH) Assays in S19 Mass‐Vaccinated Cattle in an Endemic Brucellosis Environment

Wilson J. Bonilla-Machado, Andrés Aguilar-Chavarría, Carlos Chacón-Díaz, Elias Barquero-Calvo et autres

Controlling bovine brucellosis requires reliable diagnostics and effective vaccination strategies. We evaluated the performance of three serological assays—the rose bengal test (RBT), competitive ELISA (cELISA), and agar gel immunodiffusion (AGID) with native hapten (NH)+lipopolysaccharide (LPS) antigen—following Brucella abortus S19 vaccination under different …

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Brucella abortus egresses from host cells in infective clusters through an actin-dependent mechanism

José Fabio Campos Godínez, Alejandro Hernández Saborío, Tiffany Vargas Moya, Valeria Gómez Vargas et autres

Brucella abortus is an intracellular pathogen whose cell cycle encompasses attachment, internalization, trafficking, replication, and egress from host cells. Although the intracellular life of Brucella has been extensively studied, the mechanisms underlying its exit from host cells remain unclear. In this work, …

The Brucella genomic origami: How bacteria without plasmids or external recombination evolve and adapt to their intracellular niche

Edgardo Moreno

A comprehensive understanding of Brucella genomic evolution requires the integration of multiple analytical scales, each offering distinct resolutions to capture fine-level mutations and broad structural modifications. Most evolutionary and pathophysiological studies have focused on single-nucleotide polymorphisms and gene-level mutations to elucidate the …

Cell-to-cell transmission of Brucella abortus

Jose Fabio Campos Godinez, Carlos Chacón‐Díaz, Edgardo Moreno, Esteban Chaves‐Olarte et autres

Abstract Brucella abortus is a persistent intracellular pathogen capable of evading early immune responses. To explore the mechanism of exit of this bacterium, we monitored Brucella infection by live cell imaging for up to 100 hours. This approach uncovered various modes of …

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Brucella abortus egresses from host cells in infective clumps through an actin-dependent mechanism

Jose Fabio Campos Godinez, Ignacio V. Sandoval, Reynaldo Pereira, Carlos Chacón‐Díaz et autres

Abstract Brucella abortus is an intracellular pathogen whose cell cycle encompasses attachment, internalization, trafficking, replication, and egress from cells. While the intracellular life of Brucella has been extensively studied, the mechanisms underlying its exit from host cells are still unclear. In this …

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Author Correction: Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils

Joaquín Miguel Pellegrini, Gabriela González-Espinoza, Raheleh R. Shayan, Lisiena Hysenaj et autres

In this article there was an error in Figure 9, the dashes before the log of the p values where omitted. The original article has been corrected.

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Brucella abortus impairs T lymphocyte responsiveness by mobilizing IL-1RA-secreting omental neutrophils

Joaquín Miguel Pellegrini, Gabriela González-Espinoza, Raheleh R. Shayan, Lisiena Hysenaj et autres

Immune evasion strategies of Brucella, the etiologic agent of brucellosis, a global zoonosis, remain partially understood. The omentum, a tertiary lymphoid organ part of visceral adipose tissue, has never been explored as a Brucella reservoir. We report that B. abortus infects and …

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Reactivation of hidden-latent Brucella infection after doxycycline and streptomycin treatment in mice

Eugenia Sancho-Sánchez, Kimberly García-Arteaga, Fabio Granados-Chinchilla, Graciela Artavia et autres

ABSTRACT Brucellosis has therapeutic challenges due to 3%–15% relapses/therapeutic failures (R/TF) after antibiotic treatment. Therefore, determining the antibiotic concentration in tissues, the physiopathological parameters, and the R/TF after treatment is relevant. After exploring different antibiotic quantities, we found that a combined dose …

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Why are Latin American countries in the limbo of open-access scientific publications?

Max Chavarría, Bruno Lomonte, José Marı́a Gutiérrez, Edgardo Moreno et autres

Abstract Open Access (OA) model in scientific journals has brought about a range of benefits in terms of information accessibility. However, the high costs associated with Article Processing Charges (APCs) have posed a significant challenge for many scientists, leaving them in a …

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