Quanxiu Gao

DeepHalo: Deep learning-powered exploration of halogenated metabolites uncovering antibacterial depsipeptides

Shanshan Chang, Xin Qi, Mengyuan Wang, Xinyue Huang et autres

In the omics era, confident high-throughput analytical tools are crucial for the efficient identification of metabolites. Here, we present DeepHalo, a deep learning-integrated and hierarchically optimized workflow designed for high-throughput exploration of halogenated metabolites from high-resolution mass spectrometry-based metabolomics. DeepHalo leverages deep …

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DeepHalo: Deep Learning-Powered Exploration of Halogenated Metabolites Uncovering Antibacterial Depsipeptides

Shanshan Chang, Xin Qi, Mengyuan Wang, Xinyue Huang et autres

ABSTRACT In the omics era, confident high-throughput analytical tools are crucial for the efficient identification of metabolites. Here, we present DeepHalo, a deep learning-integrated and hierarchically optimized workflow designed for high-throughput exploration of halogenated metabolites from high-resolution mass spectrometry-based metabolomics. DeepHalo leverages …

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Improving poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis with the construction of a genome-scale metabolic model for Haloferax mediterranei

Quanxiu Gao, Luhui Zhang, Wei‐Ran Huang, Yue Zhang et autres

Polyhydroxyalkanoates (PHAs) are biodegradable plastics emerging as sustainable alternatives to petroleum-based plastics. Haloferax mediterranei has shown strong potential for large-scale production of poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) using cheap carbon sources as substrates. To facilitate rational strain engineering, we constructed the first genome-scale …

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Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux

Lin Lin, Junyu Chen, Ruchira Mitra, Quanxiu Gao et autres

The haloarchaeon Haloferax mediterranei is a potential strain for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) production, yet the production yield and cost are the major obstacles hindering the use of this archaeal strain. Leveraging the endogenous type I-B CRISPR-Cas system in H. mediterranei, we develop a …

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Highly Efficient Production of Menaquinone-7 from Glucose by Metabolically Engineered Escherichia coli

Quanxiu Gao, Hao Chen, Gaoyan Wang, Wei Yang et autres

Menaquinone-7 (MK-7) possesses wide health and medical value, and the market demand for MK-7 has increased. Metabolic engineering for MK-7 production in Escherichia coli still remains challenging due to the characteristics of the competing quinone synthesis, and cells mainly synthesized menaquinones under …

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Menaquinone-7 production in engineered Escherichia coli

Quanxiu Gao, Hao Chen, Wenzhao Wang, Jianzhong Huang et autres

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Metabolic engineering of Escherichia coli for efficient production of l-alanyl-l-glutamine

Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu et autres

BACKGROUND: L-Alanyl-L-glutamine (AQ) is a functional dipeptide with high water solubility, good thermal stability and high bioavailability. It is widely used in clinical treatment, post-operative rehabilitation, sports health care and other fields. AQ is mainly produced via chemical synthesis which is complicated, …

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Metabolic engineering of Escherichia coli for efficient production of L-alanyl-L-glutamine

Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu et autres

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Metabolic engineering of Escherichia coli for efficient production of L-alanyl-L-glutamine

Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu et autres

Abstract Background L-alanyl-L-glutamine (AQ) is a functional dipeptide with high water solubility, good thermal stability and high bioavailability. It is widely used in clinical medicine, post-operative rehabilitation, sports health care and other fields. AQ is mainly produced by chemical synthesis which is …

cn, cz (code pays fourni par la source)

Metabolic engineering of Escherichia coli for efficient production of L-alanyl-L-glutamine

Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu et autres

Abstract Background: L-alanyl-L-glutamine (AQ) is a functional dipeptide with high water solubility, good thermal stability and high bioavailability. It is widely used in clinical medicine, post-operative rehabilitation, sports health care and other fields. AQ is mainly produced by chemical synthesis which is …

cn, cz (code pays fourni par la source)

Integrated analyses of transcriptome, proteome and fatty acid profilings of the oleaginous microalga Auxenochlorella protothecoides UTEX 2341 reveal differential reprogramming of fatty acid metabolism in response to low and high temperatures

GuanLan Xing, Hongli Yuan, Jinshui Yang, Jinyu Li et autres

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Transcriptomic and Ectoine Analysis of Halotolerant Nocardiopsis gilva YIM 90087T Under Salt Stress

Jian Zhong Han, Quanxiu Gao, Yong-Guang Zhang, Li Li et autres

The genus Nocardiopsis is a unique actinobacterial group that widely distributed in hypersaline environments. In this study, we investigated the growth conditions, transcriptome analysis, production and accumulation of ectoine by Nocardiopsis gilva YIM 90087T under salt stress. The colony color of N. …

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