Mallikarjun Badadani

A Spondylo Epi (meta) Physeal Dysplasia: Hypocalcitonemia in Handigodu Disease

Mallikarjun Badadani, K. Taranath Shetty, S. S. Agarwal

Handigodu Disease (HD) is a disorder of the osteoarticular system which is highly prevalent in several villages of two districts viz, Shimoga and Chikmaglur of the state of Karnataka, southern India. It is a rare and painful osteoarthritic disorder. The disease is …

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Pyk2 contributes to reepithelialization by promoting MMP expression. Focus on “Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice”

Dana T. Graves, Yingying Wu, Mallikarjun Badadani

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Exercise Training Reverses Skeletal Muscle Atrophy in an Experimental Model of VCP Disease

Angèle Nalbandian, Christopher Nguyen, Veeral Katheria, Katrina J. Llewellyn et autres

BACKGROUND: The therapeutic effects of exercise resistance and endurance training in the alleviation of muscle hypertrophy/atrophy should be considered in the management of patients with advanced neuromuscular diseases. Patients with progressive neuromuscular diseases often experience muscle weakness, which negatively impact independence and …

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The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology

Angèle Nalbandian, Katrina J. Llewellyn, Masashi Kitazawa, Hong Yin et autres

Valosin containing protein (VCP) mutations are the cause of hereditary inclusion body myopathy, Paget's disease of bone, frontotemporal dementia (IBMPFD). VCP gene mutations have also been linked to 2% of isolated familial amyotrophic lateral sclerosis (ALS). VCP is at the intersection of …

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Autophagy Mechanism, Regulation, Functions, and Disorders

Mallikarjun Badadani

Autophagy is a self-digesting mechanism responsible for removal of damaged organelles, malformed proteins during biosynthesis, and nonfunctional long-lived proteins by lysosome. Autophagy has been divided into three general types depending on the mechanism by which intracellular materials are delivered into lysosome for …

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A progressive translational mouse model of human valosin‐containing protein disease: The VCPR155H/+ mouse

Angèle Nalbandian, Katrina J. Llewellyn, Mallikarjun Badadani, Hong Yin et autres

INTRODUCTION: Mutations in the valosin-containing protein (VCP) gene cause hereditary inclusion body myopathy (IBM) associated with Paget disease of bone (PDB), and frontotemporal dementia (FTD). More recently, these mutations have been linked to 2% of familial amyotrophic lateral sclerosis (ALS) cases. A …

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Clinical Spectrum of VCP Myopathy, Paget Disease, and fronTotemporal Dementia: Experimental Models and Potential Treatments

Virginia Kimonis, Eric Dec, Mallikarjun Badadani, Angèle Nalbandian et autres

Author(s): Kimonis, Virginia E; Dec, Eric; Badadani, Mallikarjun; Nalbandian, Angele; Vesa, Jouni; Caiozzo, Vincent; Wallace, Douglas; Martin, Barbara; Smith, Charles; Watts, Giles D | Editor(s): Engel, WK

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Valosin-Containing Protein (VCP) Disease and Familial Alzheimer’s Disease: Contrasts and Overlaps

CD Smith, Mallikarjun Badadani, Angèle Nalbandian, Eric Dec et autres

S Donkervoort, B Martin, GD Watts, V Caiozzo and V Kimonis (2011).Valosin-Containing Protein (VCP) Disease and Familial Alzheimer's Disease: Contrasts and Overlaps, The Clinical Spectrum of Alzheimer's Disease -The Charge Toward Comprehensive Diagnostic and Therapeutic Strategies, Dr.

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The Multiple Faces of Valosin-Containing Protein-Associated Diseases: Inclusion Body Myopathy with Paget’s Disease of Bone, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis

Angèle Nalbandian, Sandra Donkervoort, Eric Dec, Mallikarjun Badadani et autres

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VCP Associated Inclusion Body Myopathy and Paget Disease of Bone Knock-In Mouse Model Exhibits Tissue Pathology Typical of Human Disease

Mallikarjun Badadani, Angèle Nalbandian, Giles D. Watts, Jouni Vesa et autres

Dominant mutations in the valosin containing protein (VCP) gene cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). We have generated a knock-in mouse model with the common R155H mutation. Mice demonstrate progressive muscle weakness starting approximately …

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Hypocalcitonemia in Handigodu Disease: a spondylo epi (meta) physeal dysplasia.

Mallikarjun Badadani, K. Taranath Shetty, SS Agarwal

Handigodu Disease (HD) is a disorder of the osteoarticular system which is highly prevalent in several villages of two districts viz, Shimoga and Chikmaglur of the state of Karnataka, southern India. The scientific name of the disease is Spondylo-epi-(meta) physeal Dysplasia, Autosomal …

OPTIMUM PYROLYTIC CONDITIONS FOR FURAN DERIVATIVE FORMATION FROM POLYAMINO SUGARS

Mallikarjun Badadani, K. Taranath Shetty

Furan derivatives were prepared by hydrolysis of glucosamine derived from polyamino sugars assisted with pyrolysis in alkaline condition. Pyrolysis was carried out with autoclaving at 15 psi/121 degrees C/1 hour. The reaction was monitored by observing spectral characteristics at lambda(max) 545 nm …

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