Daniel Boon Loong Teh

Advancing Treatment of Degenerative Eye Diseases at the Nanoscale

Li Yao Jin, Evashiniee G. P. Selvam, Qingsong Mei, Chi D. Luu et autres

Degenerative ocular diseases are characterized by a convergence of molecular perturbations, including oxidative stress, chronic inflammation, failure of proteostasis, mitochondrial dysfunction, abnormal angiogenic signaling, and biomechanical remodeling. The eye's unique architecture, sealed by the blood-retina barrier, presents formidable anatomical and cellular topological …

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Dilating the aging clock with light

Jessica Jing Yi Chang, Ivan Yee Man Ho, Clarissa Bernice Quah, Yu Yin Bai et autres

Precise and rapid modeling of aging remains a significant challenge. This review explores the potential of emerging light-based technologies-including direct light exposure, photodynamic therapy (PDT), and optogenetics-as accelerated, mechanistically targeted models for interrogating aging processes. Unlike conventional methods that rely on chronologically …

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Photodynamic therapy management of canine mammary gland tumour with wireless upconversion implant

Ivy Joy Toh, Jasen Ly, Bowen Sun, Jannah Kamarudin et autres

Abstract In photodynamic therapy (PDT), efficacious tumour regression is attained through sufficient illumination intensity and frequency across photosensitised tumour area. An emerging tether‐free optical implantable is realised by shifting the excitation to tissue penetrating near‐infrared with upconversion nanoparticles (UCNPs). Despite advances in …

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Nanothermometry for Cellular Temperature Monitoring and Disease Diagnostics (2/2024)

Meilin Liu, Yaru Sun, Daniel Boon Loong Teh, Yi Zhang et autres

This cartoon illustrates temperature monitoring of the normal and inflammatory (fever) sites in the body by the luminescent nanothermometers for disease diagnosis. In this review paper, various nano-thermometers have been summarized for in vitro and in vivo temperature detections, and disease diagnosis …

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response

Matius Robert, Rekha Jakhar, Bijin Veonice Au, Gracie Wee Ling Eng et autres

ABSTRACT Triple-negative breast cancers (TNBC), associated with poor prognosis and high tumour recurrence, are often-treated with taxanes in first-line treatment regimens. However, acquired disease resistance can often set in, hampering clinical efficacy. One avenue that could engender therapy resistance is therapy-induced senescence …

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Nanothermometry for cellular temperature monitoring and disease diagnostics

Meilin Liu, Yaru Sun, Daniel Boon Loong Teh, Yi Zhang et autres

Abstract Body temperature variations, including the generation, transfer, and dissipation of heat, play an important role throughout life and participate in all biological events. Cellular temperature information is an indispensable link in the comprehensive understanding of life science processes, but traditional testing …

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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Antonino Glaviano, Aaron Song Chuan Foo, Hiu Yan Lam, Kenneth Chun-Yong Yap et autres

The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-interactions with …

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SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy

Jannah Kamarudin, Bowen Sun, Aaron Song Chuan Foo, Xin Yuan Lim et autres

Present day strategies for delivery of wireless photodynamic therapy (PDT) to deep-seated targets are limited by the inadequacy of irradiance and insufficient therapeutic depth. Here we report the design and preclinical validation of a flexible wireless upconversion nanoparticle (UCNP) implant (SIRIUS) that …

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The global impact of COVID-19 on abortion care

Isabella Ong, Aqilah Dariah Mohd Zulkarnain, Kelly Zhi Qi Lim, Daniel Boon Loong Teh et autres

Background: The COVID-19 pandemic placed unprecedented strain on healthcare globally, which exacerbated factors leading to unplanned pregnancies. Objectives: The primary objective was to analyze the effect of COVID-19 on abortion services globally. Secondary objectives were to discuss issues regarding access to safe …

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COVID-19, Blood Lipid Changes, and Thrombosis

Akhlaq A. Farooqui, Tahira Farooqui, Grace Y. Sun, Teng‐Nan Lin et autres

Although there is increasing evidence that oxidative stress and inflammation induced by COVID-19 may contribute to increased risk and severity of thromboses, the underlying mechanism(s) remain to be understood. The purpose of this review is to highlight the role of blood lipids …

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Biomimetic nanotherapeutics for targeted drug delivery to glioblastoma multiforme

Xin Yuan Lim, Sharah Mae Capinpin, Nagarjun Bolem, Aaron Song Chuan Foo et autres

Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis and high mortality, with no curative treatment to date as limited trafficking across the blood-brain barrier (BBB) combined with tumor heterogeneity often leads to therapeutic failure. Although modern medicine poses a …

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Unraveling female reproductive senescence to enhance healthy longevity

Lu Dong, Daniel Boon Loong Teh, Brian K. Kennedy, Zhongwei Huang

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