Amruta Damle‐Vartak

A Serum lncRNA Signature Determines Oncogenic YAP Activity in Cancer Patients

Fabian Rose, Nada El-Ekiaby, Lilija Wehling, Sofia M.E. Weiler et autres

Biomarkers are typically identified by comparing human samples such as tissues and serum. However, reliable markers for transcriptionally active oncogenes remain elusive due to tumor heterogeneity and confounding signals from non-tumorous cells. We hypothesize that in vitro screening is sufficient to identify …

de, Égypte (code pays fourni par la source)

Cholangiocyte RAGE drives the ductular reaction which provides biliary drainage but fuels liver injury

Nachiket Vartak, Amruta Damle‐Vartak, Simone Joers, Georgia Guenther et autres

de, us, Égypte (code pays fourni par la source)

Dynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication

Kaijing Liu, Lilija Wehling, Shan Wan, Sofia M.E. Weiler et autres

INTRODUCTION: The Hippo pathway and its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are targets for cancer therapy. It is important to determine if the activation of one factor compensates for the inhibition of the other. Moreover, …

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Characterization of a cholestasis-specific long non-coding RNAs (lncRNAs) signature in chronic liver disease

Amruta Damle‐Vartak

‘Cholestasis’ is impaired liver bile excretion that occurs commonly in various chronic liver diseases (CLDs). Chronic cholestasis progresses to fibrosis, cirrhosis, or even fatality. Hence the early detection of cholestasis is crucial. Conventional biomarkers based on liver enzymes and serum metabolites are …

de (code pays fourni par la source)

Biliary epithelial cell-specific RAGE controls ductular reaction-mediated fibrosis during cholestasis

Wai Ling Macrina Lam, Amruta Damle‐Vartak, Gisela Gabernet, Doris Schneller et autres

de (code pays fourni par la source)

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Tim Brecklinghaus, Wiebke Albrecht, Franziska Kappenberg, Julia Duda et autres

An in vitro/in silico method that determines the risk of human drug induced liver injury in relation to oral doses and blood concentrations of drugs was recently introduced. This method utilizes information on the maximal blood concentration (Cmax) for a specific dose …

de, Égypte, gb, nl, at, ps (code pays fourni par la source)

Liver progenitor cells regulate ductular reaction and induce fibrosis upon severe liver injury via RAGE signaling

WLM Lam, Gisela Gabernet, Tanja Poth, Aurora De Ponti et autres

The origin and role of liver progenitor cells (LPCs) also known as atypical biliary epithelial-like cells have been a controversial topic from their involvement in regeneration during liver damage to being associated with severe liver disease progression, fibrosis and tumor initiation. Enhanced …

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Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion‐Dominated Canalicular and Flow‐Augmented Ductular Bile Flux

Nachiket Vartak, Georgia Guenther, F Joly, Amruta Damle‐Vartak et autres

BACKGROUND AND AIMS: Small-molecule flux in tissue microdomains is essential for organ function, but knowledge of this process is scant due to the lack of suitable methods. We developed two independent techniques that allow the quantification of advection (flow) and diffusion in …

de, fr, Égypte, se, nl (code pays fourni par la source)

Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux

Nachiket Vartak, Georgia Guenther, F Joly, Amruta Damle‐Vartak et autres

Abstract Small-molecule flux in tissue-microdomains is essential for organ function, but knowledge of this process is scant due to the lack of suitable methods. We developed two independent techniques that allow the quantification of advection (flow) and diffusion in individual bile canaliculi …

de, fr, Égypte, se, nl (code pays fourni par la source)

Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis

Amruta Damle‐Vartak, Brigitte Begher‐Tibbe, Georgia Günther, Fabian Geisler et autres

de (code pays fourni par la source)

3D visualization of the biliary tree by X-ray phase-contrast computed tomography

Amruta Damle‐Vartak

de (code pays fourni par la source)

Single cell polarity in liquid phase facilitates tumour metastasis

Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini et autres

Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of …

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