Gang Cao

Purine-Metabolism Reprogramming Associated with Failed-Repair Proximal Tubule States in the AKI-to-CKD Transition

Jiahui Zhang, Keze Song, Wenlong Han, Zhichao Wang et autres

Background/Objectives: The acute kidney injury (AKI) to chronic kidney disease (CKD) transition has been associated with a failed-repair proximal tubule (FR-PT) cell state. Hyperuricemia is an established CKD risk factor, but whether FR-PT cells have a coordinated metabolic signature reproducibly detectable across …

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Correction: Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure

Jiayan Xie, Yujing Yang, Wanting Chen, Lu Wang (45927) et autres

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Protein acetylation modification in tissue fibrosis: Opportunities and challenges

Jie Hu, Xinyue Dou, Yongyuan Xiao, Lixiang Gao et autres

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Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure

Jiayan Xie, Yujing Yang, Wanting Chen, Lu Wang (45927) et autres

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The Mechanism Of C Migration And Aggregation

Gang Cao

Aim or purpose To study on the Mechanism of AFAP1-AS1 in the Induction of periodontal ligament stem cells Migration and Aggregation by Fluoroapatite Modified Polycaprolactone Nanofiber Scaffold Materials and methods By using fluoride ion detector, inductively coupled plasma mass spectrometry, live cell …

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Small molecules targeting regulated cell death for chronic kidney disease therapy

Wen-Kai Yu, Qing-Ru Zhu, Li Zhou, Xin-Lei Shen et autres

Chronic kidney disease (CKD) is a significant contributor to the global morbidity of non-communicable diseases and is predicted to become the fifth leading cause of death worldwide. However, effective treatments that directly target the underlying causes of CKD remain limited due to …

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Targeting AKT to treat liver disease: Opportunities and challenges

Zeping Wang, Xinyue Dou, Qiyuan Shan, Ning Yan et autres

AKT, a serine/threonine kinase, is essential for liver homeostasis and is critically involved in the pathogenesis of a wide spectrum of liver diseases. It regulates multiple downstream signaling pathways Through phosphorylation of downstream substrates, AKT modulates key cellular processes including lipid metabolism, …

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Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice

Shijia Liu, Hai‐Jian Sun, Zijing Du, Shuai Lü et autres

To date, treating ulcerative colitis (UC) remains a significant challenge due to its complex etiology. In this study, metabolomics and proteomics analysis for multi-center cohorts reveal that both serum arginine levels and the rate-limiting enzyme argininosuccinate synthetase 1 (ASS1) are significantly elevated …

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Biological potential and mechanisms of Brain-Expressed X-linked family proteins in cancers: an updated review

Ziyan Chen, Hongyan Zhang, Yao Lu, Licheng Zhou et autres

BACKGROUND: Brain-Expressed X-linked (BEX) family proteins is a relative younger protein family in human being, with limited understanding of its pathophysiological functions in health and disease. So far, The human BEX family consists of five members including BEX1-5, which have highly homologous …

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Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease

Yanni Wang, Xin Wu, Qiao Yang, Xiao‐Yong Yu et autres

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Unveiling the detoxification components and mechanisms of glycyrrhizae radix et rhizoma: Traditional and modern clinical perspectives

Jie Dong, Gang Tian, Qing‐Hua Xu, Wenli Jiang et autres

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Bioactive fraction of processed Curcumae Rhizoma-Sparganii Rhizoma anti-liver fibrosis by regulate taurine metabolism through PI3K/AKT pathway

Min Hao, Ziyan Chen, Pingping Wang, Yandan Lu et autres

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