Hae‐Chul Park

FUS-driven zebrafish model of ALS identifies tribenzylamine as a candidate modulator of ALS-associated pathology

Yongbo Seo, Jeonghyeon Lee, Yunkyoung Lee, Suhyun Kim et autres

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron loss and declining motor function; however, effective therapies remain limited. To support unbiased therapeutic discovery, we aimed to develop a high-throughput phenotypic screening platform based on a transgenic zebrafish …

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Zebrafish Models of Parkinson’s Disease: From Pathogenesis to Drug Discovery

Hae‐Chul Park, Yongbo Seo, Yeo Jeong Han, Su Hee Cho et autres

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the aggregation of Lewy bodies, composed of the protein α-synuclein, and the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta. The management of PD seeks to mitigate motor symptoms by …

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Functional impact of the ATP1A3-p.A813V variant: insights into a calcium-driven hyperexcitability cascade in rapid-onset dystonia-Parkinsonism

Su Min Lim, Suhyun Kim, Jinseok Park, Young-Eun Kim et autres

Mutations in the neuronal Na + /K + -ATPase subunit ATP1A3 are linked to a spectrum of neurological disorders, including rapid-onset dystonia-parkinsonism (RDP), yet their pathogenic mechanisms remain incompletely understood. We describe the complex clinical characteristics of a patient with early-onset movement …

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The Neuropeptide Fam19a5a/tafa5a Regulates Inflammation and Influences Anxiety‐Like Behaviours in Zebrafish

Inyoung Jeong, Seong Soon Kim, Hwan‐Ki Kim, Myung Ae Bae et autres

Anxiety is a future-oriented mood state that consists of a complex cognitive, affective, physiological and behavioural response system that prepares individuals for perceived or anticipated threats. Although the neural circuits underlying anxiety behaviours have been extensively studied, how inflammatory factors influence anxiety …

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Author response for "The neuropeptide fam19a5a/tafa5a regulates inflammation and influences anxiety-like behaviors in zebrafish"

Inyoung Jeong, Seong Soon Kim, Hwan‐Ki Kim, Myung Ae Bae et autres

Developmental exposure to benzalkonium chloride induces defects in mechanosensory hair cells and nociceptive responses in zebrafish

Yeonhwa Kim, Yu Ji Cho, Eun Jung Jeon, Sang Hoon Jeong et autres

Sensory neurotoxicity involves damage to the sensory nerves, often resulting from exposure to chemicals, medications, toxins, infections, or neurological disorders. Benzalkonium chloride (BKC) is a widely used quaternary ammonium compound with antiseptic properties, commonly present in pharmaceuticals, household products, and cosmetics. While …

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Author response for "The neuropeptide fam19a5a/tafa5a regulates inflammation and influences anxiety-like behaviors in zebrafish"

Inyoung Jeong, Seong Soon Kim, Hwan‐Ki Kim, Myung Ae Bae et autres

Assessment of a novel color vision optomotor response assay in zebrafish larvae with red cone ablation

Youngsub Eom, Eunheh Koh, H.-C. Park, Hae‐Chul Park et autres

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Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer’s disease

Hanbyul Kim, Sangjin Yoo, Hoyun Kwak, Shi‐Xun Ma et autres

BACKGROUND: FAM19A5 is a secretory protein primarily expressed in neurons. Although its role in synaptic function has been suggested, the precise molecular mechanisms underlying its effects at the synapse remain unclear. Given that synaptic loss is a critical hallmark of Alzheimer's disease …

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Correction: The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation

Dheeraj Rayamajhi, Mert Ege, Kirill Ukhanov, Christa Ringers et autres

[This corrects the article DOI: 10.1371/journal.pbio.3002468.].

Transforming growth factor-β receptor I kinase plays a crucial role in oligodendrocyte regeneration after demyelination

Yunkyoung Lee, Inyoung Jeong, Dong Won Lee, Yongbo Seo et autres

Multiple sclerosis (MS) is an autoimmune disease characterized by the loss of oligodendrocytes (OLs) and axon demyelination in the central nervous system. Most therapeutic agents focus on regulating the immune response by suppressing autoimmune reactions. Therefore, developing therapeutic agents that promote remyelination …

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Neurotoxic effects of citronellol induced by the conversion of kynurenine to 3-hydroxykynurenine

Seong Soon Kim, Suhyun Kim, Yeonhwa Kim, Yoon‐Cheol Ha et autres

Citronellol is widely utilized in consumer products, including cosmetics, fragrances, and household items. However, despite being considered a relatively safe chemical, the health effects and toxicity mechanisms associated with exposure to high concentrations of citronellol, based on product content, remain inadequately understood. …

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