Agustín Videla Garrido

Preliminary Development and Clinical Evaluation of a Locally Produced ELISA for Urinary Histoplasma Antigen Detection in Argentina

Agustín Videla Garrido, Víctor Fernández Briceño, Carolina Rodríguez Laboccetta, Gladys B. Posse et autres

Background: Histoplasmosis is a major opportunistic fungal infection in immunocompromised individuals, particularly people living with HIV in Latin America. Early diagnosis is essential to reduce morbidity and mortality, but commercial urinary Histoplasma antigen assays are not consistently accessible in many endemic settings. …

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COVID-19–associated invasive fungal infections in intensive care unit patients during the first pandemic waves in Argentina: Results of a single center experience

Gladys Posse, Fernanda Barberis, María Fernanda Benedetti, Daniel Pezzola et autres

Critically ill COVID-19 patients are at high risk for invasive fungal infections (IFIs). Data on IFI prevalence in severe COVID-19 patients in Latin America are scarce. This study aimed at analyzing the prevalence and outcomes of IFIs in COVID-19 patients from Argentina. …

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Histoplasmaantigens as novel players for the development of new enzyme immunoassays for the serodiagnosis of histoplasmosis: A comparative study of their analytical performance

Carolina Rodríguez Laboccetta, Victor Fernandez, Agustín Videla Garrido, Gladys Posse et autres

Definitive diagnosis of histoplasmosis relies on culture and/or cytology/histopathology; however, these procedures have limited sensitivity and cultures are time-consuming. Antibodies detection by immunodiffusion has low sensitivity in immunocompromised individuals and uses histoplasmin (HMN), a crude antigenic extract, as reagent. Novel protein antigen …

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Evaluation of the Histoplasma capsulatum 100-kilodalton antigen dot blot for the rapid diagnosis of progressive histoplasmosis in HIV/AIDS patients

Carolina Rodríguez Laboccetta, María Agustina Toscanini, Agustín Videla Garrido, Gladys Posse et autres

Among people living with HIV (PLHIV), progressive disseminated histoplasmosis (PDH) represents an important cause of mortality. Since antigen detection allows a rapid diagnosis and the instauration of a specific treatment this study aimed to evaluate the analytical performance of the Hcp100 dot …

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Evidence of anti-Hcp100 antibodies in COVID-19 critically ill patients with detectable anti-histoplasmin antibodies in a highly endemic area for histoplasmosis

María Agustina Toscanini, Fernanda Barberis, Fernanda Benedetti, Carolina Rodríguez Laboccetta et autres

Patients with severe COVID-19 are at increased risk for invasive fungal infections, which are underestimated. Histoplasmosis reactivation in endemic areas should not be overlooked in this population. In a previous study, seroconversion to anti-histoplasmin antibodies by ELISA was detected in 6/39 (15.4%) …

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Role of recombinant Histoplasma capsulatum 100‐kilodalton antigen in the diagnosis of histoplasmosis among HIV/AIDS patients: Antigenuria and antibodies detection

María A. Toscanini, Carolina Rodríguez Laboccetta, Agustín Videla Garrido, Gladys Posse et autres

BACKGROUND: Diagnosing progressive disseminated histoplasmosis (PDH) is still challenging in many countries where this disease is highly endemic. Definitive diagnosis is established by culture and/or by cytology/histopathology but both procedures have limited sensitivity and cultures are time-consuming. Antibodies detection by immunodiffusion has …

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Detection of anti-Histoplasma capsulatum antibodies and seroconversion patterns in critically ill patients with COVID-19: An underdiagnosed fungal entity complicating COVID-19?

María Agustina Toscanini, Fernanda Barberis, María Fernanda Benedetti, Agustín Videla Garrido et autres

The patients with severe COVID-19 are at increased risk for invasive fungal infections, such as invasive pulmonary aspergillosis and candidiasis, which increase morbidity and mortality. However, clinicians should also consider the possibility of reactivating latent Histoplasma capsulatum in patients with severe COVID-19 …

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Polymeric micelles and nanomedicines: Shaping the future of next generation therapeutic strategies for infectious diseases

María A. Toscanini, María José Limeres, Agustín Videla Garrido, Maximiliano Cagel et autres

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