Jeongmin Ha

WNK kinase regulates plasma membrane levels of the WNT inhibitor RNF43

Gabriele Colozza, Ingrid Jordens, Eric Sosa, Jeongmin Ha et autres

The E3 ubiquitin ligases RNF43 and ZNRF3 are key negative regulators of canonical WNT signaling, promoting turnover of the WNT receptors FRIZZLED and LRP5/6 at the plasma membrane. While their mechanism of action is well established, how RNF43/ZNRF3 themselves are regulated remains …

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Brazilein Impedes IKK Activation by Disrupting RIPK1 Polyubiquitination, Increasing Apoptotic Susceptibility in Cells with Constitutively Active NF-κB

Kyeong Ah Park, Hee Sun Byun, Jeongmin Ha, Chul‐Joong Kim et autres

L., inhibits the catalytic activity of the IKK complex during TNF-mediated NF-κB activation without affecting RIPK1 ubiquitination at high concentrations (~50 μM), raising concerns about off-target effects. In this study, we now report that brazilein, an oxidized derivative of brazilin, acts as …

kr (code pays fourni par la source)

Diverse bat organoids provide pathophysiological models for zoonotic viruses

Hyunjoon Kim, Seo-Young Heo, Young‐Il Kim, Dongbin Park et autres

Bats are important reservoirs of zoonotic pathogens, but suitable model systems for comprehensively exploring host-pathogen interactions and assessing spillover risks remain limited. To address this gap, we developed a collection of bat organoid models spanning five species and four organ types. This …

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Mammalian Blastema: Possibility and Potentials

Juhyeon Nam, Byungkuk Min, Areum Baek, Sang-Yun Lee et autres

Regeneration is a process that restores the structure and function of injured tissues or organs. Regenerative capacities vary significantly across species, with amphibians and fish demonstrating a high regenerative capacity even after severe injuries. This capacity is largely attributed to the formation …

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EPRS1-mediated fibroblast activation and mitochondrial dysfunction promote kidney fibrosis

Seung Seob Son, Hee Seul Jeong, SeongWoo Lee, Eun Soo Lee et autres

Abstract Kidney fibrosis causes irreversible structural damage in chronic kidney disease and is characterized by aberrant extracellular matrix (ECM) accumulation. Although glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is a crucial enzyme involved in proline-rich protein synthesis, its role in kidney fibrosis remains unclear. The …

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Long-term three-dimensional high-resolution imaging of live unlabeled small intestinal organoids via low-coherence holotomography

Mahn Jae Lee, Jaehyeok Lee, Jeongmin Ha, Geon Kim et autres

Organoids, which are miniature in vitro versions of organs, possess significant potential for studying human diseases and elucidating their underlying mechanisms. Live imaging techniques play a crucial role in organoid research and contribute to elucidating the complex structure and dynamic biological phenomena …

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Holotomography

Geon Kim, Hervé Hugonnet, Kyoohyun Kim, Jae-Hyuk Lee et autres

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Long-Term Three-Dimensional High-Resolution Imaging of Live Unlabeled Small Intestinal Organoids Using Low-Coherence Holotomography

YongKeun Park, Mahn Jae Lee, Jaehyeok Lee, Jeongmin Ha et autres

Abstract Organoids, which are miniature, in vitro versions of organs, present significant potential for studying human diseases and elucidating underlying mechanisms. To fully appreciate and understand the complex structure and dynamic biological phenomena of organoids, live imaging techniques play a crucial role …

kr, ca, at (code pays fourni par la source)

Long-term three-dimensional high-resolution imaging of live unlabeled small intestinal organoids using low-coherence holotomography

Mahn Jae Lee, Jaehyeok Lee, Jeongmin Ha, Hye‐Jin Kim et autres

Abstract The prevailing challenges in live unlabeled high-resolution imaging of native organoids stem from technical issues like complex sample handling and optical scattering in three-dimensional architectures. In this study, we introduce low-coherence holotomography as an advanced, label-free, quantitative imaging modality, designed to …

kr (code pays fourni par la source)

Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin

Jeongmin Ha, Bum Suk Kim, Byungkuk Min, Juhyeon Nam et autres

Amphibians and fish show considerable regeneration potential via dedifferentiation of somatic cells into blastemal cells. In terms of dedifferentiation, in vitro cellular reprogramming has been proposed to share common processes with in vivo tissue regeneration, although the details are elusive. Here, we …

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Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease

Jeongmin Ha, Ji Su Kang, Minhyung Lee, Areum Baek et autres

Although brain organoids are an innovative technique for studying human brain development and disease by replicating the structural and functional properties of the developing human brain, some limitations such as heterogeneity and long-term differentiation (over 2 months) impede their application in disease …

kr (code pays fourni par la source)

Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson's Disease Patients

Minhyung Lee, Hyuna Sim, Hyunjun Ahn, Jeongmin Ha et autres

In Parkinson's disease (PD) research, human neuroblastoma and immortalized neural cell lines have been widely used as in vitro models.The advancement in the field of reprogramming technology has provided tools for generating patient-specific induced pluripotent stem cells (hiPSCs) as well as human …

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