Kyle Sundin

The PMEL gene and merle (dapple) in the dachshund: cryptic, hidden, and mosaic variants demonstrate the need for genetic testing prior to breeding

Blake C. Ballif, Lisa J. Emerson, Christina J. Ramirez, Kyle Sundin et autres

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Canine factor VII deficiency: lessons learned in applying methods-based laboratory proficiency testing

Christina J. Ramirez, Melissa J. Krug, Adam J. Zahand, Kyle Sundin et autres

Canine inherited factor VII deficiency is a mild-to-moderate, inherited coagulopathy that affects several breeds of dog. We identified 2 polymorphisms near the disease-causing F7 gene mutation, one of which interfered with testing in several Beagles by causing allele dropout of the normal, …

Standards and guidelines for canine clinical genetic testing laboratories

Lisa G. Shaffer, Kyle Sundin, Anja Geretschlaeger, Julia Segert et autres

This publication represents a proposed approach to quality standards and guidelines for canine clinical genetic testing laboratories. Currently, there are no guidelines for laboratories performing clinical testing on dogs. Thus, there is no consensus set of protocols that set the minimal standards …

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The PMEL Gene and Merle in the Domestic Dog: A Continuum of Insertion Lengths Leads to a Spectrum of Coat Color Variations in Australian Shepherds and Related Breeds

Blake C. Ballif, Christina J. Ramirez, Kyle Sundin, Melissa J. Krug et autres

Merle is a distinct coat color and pattern found in numerous species, including the domestic dog, characterized by patches of diluted eumelanin (black pigment) interspersed among areas of normal pigmentation. In dogs, this variegated pattern is caused by an insertion of a …

Genetic screening and mutation identification in a rare canine breed, the ceský fousek

Lisa G. Shaffer, Christina J. Ramirez, Kyle Sundin, Laurie B. Connell et autres

Identification of genetic mutations causing disease is helpful in breeding programmes aimed at enhancing the qualities of a breed. The ceský fousek (CF), also known as the Bohemian wirehaired pointing griffon, is a versatile hunting dog that dates back to the 14th …

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Genetic screening and mutation identification in a rare canine breed, the Drentsche patrijshond

Lisa G. Shaffer, Christina J. Ramirez, Kyle Sundin, Blake C. Ballif

The Drentsche patrijshond (Drent) is a relatively rare breed that is used as a versatile hunting dog. Although inherited diseases occur in this breed, no genetic mutations were previously known to contribute to these inherited disorders. Thirteen Drents were screened for 142 …

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The development of a rapid assay for prenatal testing of common aneuploidies and microdeletion syndromes

Lisa G. Shaffer, Justine Coppinger, S. Annie Morton, Sarah Alliman et autres

OBJECTIVE: To develop a novel, rapid prenatal assay for pregnancies with high likelihood of normal karyotypes, using BACs-on-Beads(™) technology, a suspension array-based multiplex assay that employs Luminex(®) xMAP(®) technology, for the detection of gains and losses in chromosomal DNA. METHODS: Fifteen relatively …

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Effects of Ozone Exposure during Microarray Posthybridization Washes and Scanning

Steve Byerly, Kyle Sundin, Rajiv G. Raja, Jim Stanchfield et autres

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Y-specific sequences and polymorphisms in rainbow trout and Chinook salmon

Joseph P. Brunelli, Kelsey J. Wertzler, Kyle Sundin, Gary H. Thorgaard

Improved methods for genetically sexing salmonids and for characterization of Y-chromosome homologies between species can contribute to understanding the evolution of sex chromosomes and sex-determining mechanisms. In this study we have explored 12.5 kb of Y-chromosome-specific sequence flanking the previously described OtY2 …

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Detection of low‐level mosaicism by array CGH in routine diagnostic specimens

Blake C. Ballif, Emily A. Rorem, Kyle Sundin, Matt Lincicum et autres

The advent of microarray-based comparative genomic hybridization (array CGH) promises to revolutionize clinical cytogenetics because of its ability to rapidly screen the genome at an unprecedented resolution. Yet, the ability of array CGH to detect and evaluate low-level mosaicism is not known. …

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Quantitative Trait Loci × Maternal Cytoplasmic Environment Interaction for Development Rate in Oncorhynchus mykiss

Krista M. Nichols, Karl W. Broman, Kyle Sundin, Jennifer M. Young et autres

Effects of maternal cytoplasmic environment (MCE) on development rate in rainbow trout were evaluated within a quantitative trait loci (QTL) analysis framework. Previous research had identified QTL for development rate in doubled haploid (DH) progeny produced from a cross between the Oregon …

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Targeted genomic microarray analysis for identification of chromosome abnormalities in 1500 consecutive clinical cases

Lisa G. Shaffer, Catherine D. Kashork, Reza Saleki, Emily A. Rorem et autres

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