Ugonna Olaraiche Fakile

Pulmonary tuberculosis reactivation in a 4-year-old boy on treatment for acute lymphoblastic leukemia: a case report and review of literature

Ugonna Olaraiche Fakile, Adeseye Michael Akinsete, Adebola T. Damola-Okesiji, Onyinye Odimegwu et autres

Children undergoing chemotherapy for acute lymphoblastic leukemia (ALL) are at heightened risk for opportunistic infections due to immunosuppression, including reactivation of latent tuberculosis (TB). While pulmonary TB reactivation in pediatric oncology patients is rare, it poses significant diagnostic and therapeutic challenges in …

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Sickle Cell Intrahepatic Cholestasis in a Pediatric Patient: a Case Report

Glory Toluwanibukun Odemona, Chiamaka Evangeline Obinna-Chukwu, Ugonna Olaraiche Fakile, Olaide Oludolapo Elemo et autres

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Short‐course blood transfusion therapy with hydroxyurea, a functional strategy in the management of stroke in children with sickle cell disease

EO Temiye, Adeseye Akinsete, Adetokunbo Olayinka Joacquim, Ugonna Olaraiche Fakile et autres

Cerebrovascular accidents are serious complications of sickle cell disease (SCD). Children with abnormal transcranial Doppler (TCD) readings are at higher risk for stroke, and those with prior strokes have increased risk of recurrence. Chronic blood transfusion therapy (BTT) is the standard treatment …

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Implementation of a Dedicated Hematopoietic Stem Cell Transplant Program for Sickle Cell Disease in Lagos, Nigeria: Challenges and Opportunities

Adeseye M. Akinsete, Olufunto Olufela Kalejaiye, Ugonna Olaraiche Fakile, Yusuf Adelabu et autres

Comprehensive strategies are crucial for alleviating the substantial burden of sickle cell disease (SCD) in sub-Saharan Africa. Allogeneic hematopoietic stem cell transplantation (alloHSCT) offers a potentially scalable and cost-effective cure for eligible SCD patients; however, it is currently available in only seven …

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Atypical presentation of type 2 Pleuropulmonary Blastoma as a second cancer in a 5-year-old boy: A case report

Adebola T. Damola-Okesiji, Ugonna Olaraiche Fakile, Oluwaseun A. Afoke, Michael Sanusi et autres

ABSTRACT Pleuropulmonary Blastoma (PPB) presents unique challenges due to its rarity, diverse clinical behaviors, and association with germline DICER1 mutations, emphasizing the need for advanced diagnostics and multidisciplinary management. This case describes the atypical presentation of type 2 PPB, the early development …

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Unmasking a Hidden Burden: Chemotherapy-Induced and Exacerbated Diabetes in Paediatric Cancer: A Report of Two Cases

Elizabeth Eberechi Oyenusi, Ugonna Olaraiche Fakile, Rebecca Ene Ojabo, Oluwadamilola Moromoke Oladipo et autres

L-asparaginase and corticosteroids, essential components of paediatric leukaemia and lymphoma treatment, are associated with hyperglycaemia and, rarely, diabetic ketoacidosis (DKA). Chemotherapy-induced diabetes is an under-recognised complication in pediatric oncology in resource-constrained settings. Case 1: day of initiating chemotherapy, urinalysis showed glycosuria (+++) …

2842: Advanced radiotherapy techniques for pediatric brain tumors in a Sub-Saharan African Center.

Adedayo Olufemi Joseph, Adeseye Michael Akinsete, Ugonna Olaraiche Fakile, Muhammad Yaqub Habeebu et autres

Abstract 4814: Pediatric radiation treatment adherence in LMIC

Adedayo Olufemi Joseph, Adeseye Michael Akinsete, Ugonna Olaraiche Fakile, Chidiebere Agbakwuru et autres

Abstract Background: Radiation therapy plays a significant role in the treatment of pediatric cancer. However, there have been documented challenges and difficulties encountered by patients while accessing care for cancer and it has been postulated that travel distance contributes to treatment breaks …

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Precise Pediatric Cancer Diagnosis Using Immunohistochemistry: Reducing Cost of Care and Improving Outcomes in a Low and Middle-Income Setting.

Adeseye Michael Akinsete, Ugonna Olaraiche Fakile, O A Joseph, Andrea Oludolapo Akinjo et autres

Childhood cancer is a significant cause of morbidity and mortality worldwide. It is the second-leading cause of non-communicable deaths among children worldwide with more than 90% of childhood cancer-associated mortality occurring in low-income and middle-income countries. Disparity in mortality rates has been …

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Climate Change and Force Majeure on Childhood Oncology Services in a Low Resource Setting: Experience from a Tertiary Institution in Nigeria.

T P West, Adeseye Michael Akinsete, Ugonna Olaraiche Fakile, T. Fashola

Childhood cancer patients are a vulnerable population who are adversely affected by any disaster that disrupts the healthcare ecosystem. The objective of this study was to describe the impact of flooding on access to care for childhood cancer patients in Bayelsa state, …

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Nasopharyngeal Carcinoma in Childhood: Evidence of a Malfunctioning Oncology Ecosystem: A Case Series from a Low Resource Setting.

Ugonna Olaraiche Fakile, Adeseye Michael Akinsete, Adedayo Olufemi Joseph, T. Fashola et autres

Nasopharyngeal carcinoma (NPC) refers to malignancy arising from the epithelium of the nasopharynx. It is a rare tumor globally but seen in higher prevalence in certain populations associated with the endemicity of Epstein- Barr Virus. It is usually seen in clinical settings …

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Pattern of postchemotherapy-associated complicatioins in a paediatric oncology service in Lagos

Adeseye Michael Akinsete, Ugonna Olaraiche Fakile, Emmanuella Ijeoma Nwobi, Opeyemi Mercy Awofeso

Background: Globally, there is an increase in the number of pediatric oncology cases with significant morbidity and mortality in the low to middle income countries (LMIC) despite improved survival in the resource endowed nations. The increase in survival is largely due to …

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