Accès ouvert
2015
article
OpenAlex
J. Guyden, Maria Carmen Martínez, Rajendra V. E. Chilukuri, Vincent E. Reid et autres
Thymic nurse cells (TNCs) are specialized epithelial cells that reside in the thymic cortex. The initial report of their discovery in 1980 showed TNCs to contain up to 200 thymocytes within specialized vacuoles in their cytoplasm. Much has been reported since that …
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Accès ouvert
2014
article
OpenAlex
Rajendra V. E. Chilukuri, Viral Patel, Marcia Martinez, J. Guyden et autres
Stromal thymic epithelial cells with the multicellular structure unique to thymic nurse cells (TNCs) express the pH91 antigen on their cell surfaces. The multicellular TNC-complexes develop through an intimate association between αβTCR+CD4+CD8+ thymocytes and pH91-expressing cortical epithelial cells. TNCs participate in MHC-restriction …
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Accès ouvert
2009
article
OpenAlex
Tonya M. Hendrix, Rajendra V. E. Chilukuri, Marcia Martinez, Zachariah Olushoga et autres
us
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2007
article
OpenAlex
Marcia Martinez, Michael Samms, Tonya M. Hendrix, Oluwaseun Adeosun et autres
This study examines thymic nurse cell (TNC) function during T-cell development. It has been suggested that TNCs function in the removal of nonfunctional and/or apoptotic thymocytes and do not participate in major histocompatibility complex restriction. We analyzed TNCs isolated from both normal …
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2004
article
OpenAlex
Oscar Webb, Filberto Kelly, Javier Benítez, Juncheng Li et autres
us
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Accès ouvert
2001
review
OpenAlex
Mark Pezzano, Michael Samms, Marcia Martinez, J. Guyden
Since their discovery in 1980, thymic nurse cells (TNCs) have been controversial. Questions pertaining to the existence of the TNC as a "unit" cell with thymocytes completely enclosed within its cytoplasm were the focus of initial debates. Early skeptics proposed the multicellular …
us
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2001
article
OpenAlex
Michael Samms, Marcia Martinez, Sarah Fousse, Mark Pezzano et autres
us
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2001
article
OpenAlex
Mark Pezzano, Michael Samms, J. Guyden
Apoptosis of thymocytes associated with thymic nurse cells (TNCs) has been well-documented. TNCs selectively bind and internalize immature alphabeta TCRlo CD4+ CD8+ thymocytes in vitro. A subset of the internalized population matures to the alphabeta TCRhi CD69hi stage of development while the …
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2000
article
OpenAlex
S.-K. Lee, Gary A. Pestano, Janice Riley, Adam Hasan et autres
us
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1999
article
OpenAlex
Michael Samms, Deborah Philp, Finbar Emanus, Obi U. Osuji et autres
us
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1998
article
OpenAlex
Mark Pezzano, Karen D. King, Deborah Philp, Adebowale Adeyemi et autres
us
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1996
article
OpenAlex
Jianming Xie, Gary A. Pestano, Michael Samms, Sang‐Kyung Lee et autres
us
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