Jianhong Gu

Improving the Quality of Lyophilized Animal Vaccines: A Review of Optimization Strategies for Freeze-Drying Processes

Fangjing Huang, Jiajie Jiao, Zexi Wang, Hongying Jie et autres

Vacuum freeze-drying, commonly referred to as lyophilization, is one of the primary processes in vaccine industrial manufacturing. It offers significant advantages, including a marked extension of the shelf-life of dried products, effective preservation of biological activity, and user convenience. However, in the …

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Co-exposure to deoxynivalenol and hexavalent chromium is associated with intestinal injury, dysbiosis, and activation of ferroptosis and pyroptosis related pathways in broilers

Yueming Gu, Xinyuan Miao, Linrui Fan, Guodong Cai et autres

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Coexistence and combined toxic effects of principal emerging and common mycotoxins

Qiyao Jin, Xiaohui Zhou, Lingzhi Chen, Hui Zou et autres

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Lycium barbarum polysaccharides alleviate PVC microplastic-induced ferroptosis and fibrosis in duck kidneys by attenuating NCOA4-mediated ferritinophagy: an in vivo study

Yan Chen, Sifan Li, Yazhen Xue, 秦湘红 et autres

Microplastics (MPs) contamination is widespread and continues to increase. Compared to terrestrial organisms, mallards as waterfowl are more susceptible to MPs exposure. Lycium barbarum polysaccharides (LBP) are bioactive compounds extracted from goji berries; however, the mechanism by which LBP alleviates polyvinyl chloride …

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The dynamic adsorption and separation mechanisms of carbon molecular sieves for CO2/CH4 and CH4/N2 based on a high-fidelity simulation model coupling hierarchical pores and functional groups

Ran Xu, Zejun Xiao, Zhenlong Song, Jianhong Gu et autres

Carbon molecular sieves (CMSs) have received much attention in the separation of CO 2 /CH 4 and CH 4 /N 2 because of their unique pore structures; however, there remains a lack of systematic knowledge on the synergistic mechanism between hierarchical pore …

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Effective Pore Distribution and Mechanism of CO2/CH4 Dynamic Separation by Carbon Molecular Sieves

Jianhong Gu, Ran Xu, Zhenlong Song, Zejun Xiao et autres

Addressing the pressing demand for biogas and landfill-gas upgrading within the global energy transition, this work strategically combines thermodynamic and kinetic separation principles to identify, from a cooperative-separation perspective, the effective pore-size range that governs carbon molecular sieve (CMS) performance. Thirty anthracite-derived …

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Curcumin Mitigates Microplastic-Induced Damage in Livestock and Poultry: Mechanistic Insights and Strategies for Sustainable Farming

Yicheng Shi, Su Zheng, Shiying Zhu, Jiatao Zhou et autres

The pervasive contamination of microplastics and nanoplastics (MNPs) in livestock and poultry production systems represent a critical threat to animal health, productivity, and food safety. This review systematically evaluates the potential of curcumin, a natural polyphenol from Curcuma longa, to mitigate MNP-induced …

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Nrf2 Promotes BHBA-Induced Pyroptosis in Bovine Endometrial Epithelial Cells by Modulating Autophagy Mediated through Oxidative Stress

Jianjun Mu, Qiannan Sun, N Lin, Khan Ishrat et autres

Ketotic cows exhibit a heightened secondary endometritis risk through an unknown mechanism. We investigated the role of Nrf2 in ketosis-induced endometritis. Uterine tissues from ketotic cows showed higher levels of caspase-1 and GSDMD but lower levels of Nrf2 and LC3. β-Hydroxybutyrate (BHBA) …

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Inhibition of ADAM17: A New Therapeutic Strategy to Alleviate Zearalenone Toxin-Induced Liver Injury by Endoplasmic Reticulum Stress and Inflammation

Pengli Liu, Yayi Gu, Zhihao Xu, Hui Zou et autres

Zearalenone (ZEA) is a mycotoxin that heavily contaminates feed and its raw materials, entering the body through dietary intake. Although it has been reported that ZEA causes liver damage, its toxic mechanisms are unclear. In this study, we first confirmed that ZEA …

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Identification of Druggable Targets for Alzheimer's Disease by Analyzing Circulating Inflammatory Proteins With Mendelian Randomization

Hongliang An, Jianhong Gu, Taiping Li

ABSTRACT Objective To identify potential druggable targets for Alzheimer's disease (AD) by analyzing circulating inflammatory proteins using Mendelian randomization (MR). Methods Two‐sample MR analysis was employed to investigate the causal relationships between 91 circulating inflammatory proteins and AD. The primary MR method …

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Author response for "Identification of Druggable Targets for Alzheimer's Disease by Analyzing Circulating Inflammatory Proteins With Mendelian Randomization"

Hongliang An, Jianhong Gu, Taiping Li

Tunneling Nanotube‐Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury

Tao Wang, Li Wang, Jian Sun, Yan Chen et autres

Cadmium (Cd) exposure is strongly linked to various diseases and dysregulation of autophagy is a pivotal mechanism in Cd toxicity. Targeted autophagy strategies are promising for the treatment of autophagy dysregulation-related diseases, including Cd poisoning. However, the current understanding of autophagy mechanisms …

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