Laurence de Nijs

P07.17.A WHEN THE TUMOR DISAPPEARS: CLINICAL RELEVANCE OF NEGATIVE HISTOLOGY IN PITUITARY NEUROENDOCRINE TUMORS (PITNETS)

Gilles De Cannière, Laurence de Nijs, Edward Fomekong

Abstract BACKGROUND Pituitary Neuroendocrine Tumors (PitNETs) with paradoxically negative pathology (NP) have been well described in ACTH adenomas and, more rarely, in PRL and GH adenomas. NP cases are characterized by suggestive clinical, hormonal, and radiological evidence of a PitNET, yet lack …

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Surgical Treatment of Cushing’s Disease: The Lessons Learned

Laurence de Nijs, Edward Fomekong, Dominique Maiter, Christian Raftopoulos

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Harnessing brain-derived extracellular vesicles to support RDoC-based drug development

Igor Magaraggia, Julian Krauskopf, Johannes G. Ramaekers, Yang You et autres

The Research Domain Criteria (RDoC) framework offers a dimensional and transdiagnostic approach to understanding complex neuropsychiatric and neurological disorders, facilitating the development of novel therapeutics. However, the integration of cellular and molecular brain processes into the RDoC framework is hindered by the …

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To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers

Ghazi I. Al Jowf, Ziyad T. Ahmed, Rick A. Reijnders, Laurence de Nijs et autres

Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling condition resulting in a reduced quality of life and increased economic burden. The disorder is directly related to exposure to a traumatic event, e.g., a real or threatened injury, death, or …

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In vitro modeling of the neurobiological effects of glucocorticoids: A review

Katherine Bassil, Anthi C. Krontira, Thomas Leroy, Alana I.H. Escoto et autres

Hypothalamic-pituitary adrenal (HPA)axis dysregulation has long been implicated in stress-related disorders such as major depression and post-traumatic stress disorder. Glucocorticoids (GCs) are released from the adrenal glands as a result of HPA-axis activation. The release of GCs is implicated with several neurobiological …

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In vitro modeling of glucocorticoid mechanisms in stress-related mental disorders: Current challenges and future perspectives

Katherine Bassil, Laurence de Nijs, Bart P. F. Rutten, Daniel L. A. Van Den Hove et autres

In the last decade, in vitro models has been attracting a great deal of attention for the investigation of a number of mechanisms underlying neurological and mental disorders, including stress-related disorders, for which human brain material has rarely been available. Neuronal cultures …

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Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression

Yentl Y. van der Zee, Lars Eijssen, Philipp Mews, Aarthi Ramakrishnan et autres

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A Public Health Perspective of Post-Traumatic Stress Disorder

Ghazi I. Al Jowf, Ziyad T. Ahmed, Ning An, Rick A. Reijnders et autres

Trauma exposure is one of the most important and prevalent risk factors for mental and physical ill-health. Prolonged or excessive stress exposure increases the risk of a wide variety of mental and physical symptoms, resulting in a condition known as post-traumatic stress …

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MicroRNAs in posttraumatic stress disorder

Clara Snijders, Alana I.H. Escoto, Dewleen G. Baker, Richard L. Hauger et autres

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Contributors

Charlotte Bainomugisa, Dewleen G. Baker, Marco P. Boks, Dušan Braný et autres

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The Molecular Biology of Susceptibility to Post-Traumatic Stress Disorder: Highlights of Epigenetics and Epigenomics

Ghazi I. Al Jowf, Clara Snijders, Bart P. F. Rutten, Laurence de Nijs et autres

Exposure to trauma is one of the most important and prevalent risk factors for mental and physical ill-health. Excessive or prolonged stress exposure increases the risk of a wide variety of mental and physical symptoms. However, people differ strikingly in their susceptibility …

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Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility

Yentl Y. van der Zee, Casey K. Lardner, Eric M. Parise, Philipp Mews et autres

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