J. Webster

Tau, amyloid-beta and alpha-synuclein co-pathologies enhance neuropathology and neuroinflammation

J. Webster

us (code pays fourni par la source)

Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology

J. Webster, Yating Yang, Aidan T. Miller, Kasandra Scholz et autres

Abstract Alzheimer’s (AD) and Parkinson disease (PD) pathology often co-occur. Amyloid-β and phosphorylated tau are found in 30-50% of idiopathic PD cases, while α-synuclein inclusions are present in 50% of AD cases. These co-pathologies are linked to increased mortality and earlier onset …

us (code pays fourni par la source)

Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease

Aubrey M Schonhoff, D. A. Figge, Gregory P. Williams, Asta Jurkuvenaite et autres

Dopaminergic cell loss due to the accumulation of α-syn is a core feature of the pathogenesis of Parkinson disease. Neuroinflammation specifically induced by α-synuclein has been shown to exacerbate neurodegeneration, yet the role of central nervous system (CNS) resident macrophages in this …

us (code pays fourni par la source)

Different Patterns in Monthly Distribution of Clinical Relapses in Relapsing-Remitting Multiple Sclerosis between UK and Greece (P01.141)

Efthymia Gavala, Y. Zoukos, Ramesh Dasari, H. Willis et autres

Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicentre, randomized, placebo-controlled double-blind trial

Robert Bissonnette, Yves Poulin, Yabo Zhou, Jin Tan et autres

BACKGROUND: There is a need for the development of novel nonsteroidal topical drugs for the treatment of atopic dermatitis (AD). OBJECTIVES: The primary objective was to evaluate the efficacy of WBI-1001 over 6 weeks of treatment of mild to severe AD. METHODS: …

ca (code pays fourni par la source)

Efficacy and safety of topical WBI‐1001 in patients with mild to moderate psoriasis: results from a randomized double‐blind placebo‐controlled, phase II trial

Robert Bissonnette, Chantal Bolduc, Catherine Maari, Simon Nigen et autres

BACKGROUND: There is a need for the development of novel non-steroidal topical drugs for the treatment of psoriasis. OBJECTIVE: To assess the efficacy and safety of topical 1.0% WBI-1001 in patients with mild to moderate plaque psoriasis. METHODS: A total of 61 …

ca (code pays fourni par la source)

Holography and associated laser techniques in the world of the museum and archaeology

J. Webster

This paper discusses the application of pulsed laser recording for three-dimensional display of ancient artefacts, medical dissections for hospital museum exhibition and also non-destructive testing techniques for the detection of subsurface damage on such items such as paintings or frescos and other …

gb (code pays fourni par la source)

Incorporating subjective end-user perceptions in the design process: A study of leg guard comfort in cricket

J. Webster, J Roberts

During the design of sports equipment, the main focus is usually on physical performance attributes, neglecting key subjective factors such as feel or comfort. The personal protective equipment worn in sport is a typical example of where injury prevention has taken precedence …

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Images formed by laser metrology of complex substructures: new concept in non-destructive inspection

J. Webster, Vladimir B. Markov

The present paper presents the results of the remote recording, analysis and study of defect detection with laser Doppler vibrometry (LDV) coupled with shockwave excitation. The non-destructive inspection (NDI) procedure employed is based on the vibrational excitation and evaluation of test objects …

Temporary changes in populations of soil organisms after field application of entomopathogenic nematodes.

Richard Chevalier, J. Webster

To assess the effect of an inundative release of entomopathogenic nematodes on soil organisms, population densities of soil-dwelling organisms were monitored before and after an application of an aqueous suspension of Heterorhabditis megidis to field plots in mown grassland (Exp. I) at …

ca (code pays fourni par la source)

EVALUATION OF THREE ENTOMOPATHOGENIC NEMATODES (STEINERNEMATIDAE)“FOR THE CONTROL OF THE MEDITERRANEAN CLIMBING CUTWORM , Spodoptera Iittoralis UNDER LABORATORY AND GREENHOUSE CONDITIONS

Hany Hussein, J. Jersakovaz, J. Webster, Z. Mrééek

The virulence and invading efficiencyof three Steinernema nematode species on the last larval instar of Spodoptera littoraiis (Boisd.) as well as, average number of damaged leaves and consumed leaf area were investigated in laboratory and greenhouse experiments... The results proved that the …

Égypte, us, cz, ca (code pays fourni par la source)

Perspectives on nematology for the 21st century.

J. Webster

ca (code pays fourni par la source)