Mechanistic insights into gene regulation driving normal and malignant hematopoietic development from embryonic and induced pluripotent stem cell differentiation
0 citationsExperimental Hematology
Constanze Bonifer
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243Publications signalées
9084Citations signalées
2Affiliations récentes
Institutions déclarées
Domaines associés
Acute Myeloid Leukemia ResearchGenomics and Chromatin DynamicsEpigenetics and DNA MethylationProtein Degradation and InhibitorsZebrafish Biomedical Research Applications
Publications récentes
The ratio of RUNX1-ETO oncoprotein to normal RUNX1 expression determines the balance between endothelial reprogramming and hematopoietic cell growth
Floyd Hassenrueck, Katerina Terolli, Alexander Maytum, Peter Keane et autres
0 citationsbioRxiv (Cold Spring Harbor Laboratory)
1001 – HOW CELL STAGE-SPECIFIC TRANSCRIPTION FACTORS AND OUTSIDE SIGNALS REGULATE HEMATOPOIETIC STEM CELL DEVELOPMENT AND DIFFERENTIATION – A JOURNEY THROUGH TIME
0 citationsExperimental Hematology
Fusion gene depletion eliminates stemness and induces bidirectional differentiation of acute myeloid leukemia
Polina K. Derevyanko, Laura E. Swart, L. Daniel Mata Casimiro, Anita van Oort et autres
5 citationsBlood
A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression
Ruba Almaghrabi, Yara Alyahyawi, Peter Keane, Syed A. Mian et autres
6 citationsNature Communications
RUNX1::RUNX1T1 Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia
Polina K. Derevyanko, Laura E. Swart, L. Daniel Mata Casimiro, Luca van den Brink et autres
0 citationsbioRxiv (Cold Spring Harbor Laboratory)
Fusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia
Shan Lin, Michael Kotliar, Sushmitha Vallabh, Anetta Ptasinska et autres
0 citationsBlood Advances
Regulation of developmentally controlled enhancer activity by extrinsic signals in normal and malignant cells: AP-1 at the centre
Alexander Maytum, Nadine Obier, Pierre Cauchy, Constanze Bonifer
6 citationsFrontiers in Epigenetics and Epigenomics
Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells
Elizabeth Ng, Gulcan Sarila, Jacky Y. Li, Hasindu S. Edirisinghe et autres
94 citationsNature Biotechnology
Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma
Nicholas Davies, Tegan Francis, Ceri Oldreive, Maria Azam et autres
2 citationsHaematologica
Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
Daniel Coleman, Peter Keane, Paulynn Suyin Chin, Luke Ames et autres
10 citationsiScience
Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
Sophie G. Kellaway, Sandeep Potluri, Peter Keane, Helen J. Blair et autres
34 citationsNature Communications
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