Accès ouvert
2024
article
OpenAlex
Edward B. Irvine, Angel Nikolov, Mehak Zahoor Khan, Joshua M. Peters et autres
Mounting evidence indicates that antibodies can contribute towards control of tuberculosis (TB). However, the underlying mechanisms of humoral immune protection and whether antibodies can be exploited in therapeutic strategies to combat TB are relatively understudied. Here we engineered the receptor-binding Fc (fragment …
us
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2023
article
OpenAlex
Samuel R Schnittman, Wonyeong Jung, Kathleen V. Fitch, Markella V. Zanni et autres
People with HIV (PWH) appear to be at higher risk for suboptimal pathogen responses and for worse COVID-19 outcomes, but the effects of host factors and COVID-19 on the humoral repertoire remain unclear. We assessed the antibody isotype/subclass and Fc-receptor binding Luminex …
us
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Accès ouvert
2023
article
OpenAlex
Paulina Kapłonek, Deniz Cizmeci, Jessica Shih-Lu Lee, Sally A. Shin et autres
Despite the success of existing COVID-19 vaccine platforms, the persistent limitations in global deployment of vaccines and waning immunity exhibited by many of the currently deployed vaccine platforms have led to perpetual outbreaks of SARS-CoV-2 variants of concern. Thus, there is an …
us, ca
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Accès ouvert
2022
article
OpenAlex
Jonathan D. Herman, Chuangqi Wang, John Stephen Burke, Yonatan Zur et autres
Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP), a passive polyclonal antibody therapeutic agent, has had mixed clinical results. Although antibody neutralization is the predominant approach to benchmarking CCP efficacy, CCP may also influence the evolution of the endogenous antibody response. Using systems …
us
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Accès ouvert
2022
article
OpenAlex
Christina B. Karsten, Yannic C. Bartsch, Sally A. Shin, Matthew D. Slein et autres
While Epstein-Barr virus causes mostly asymptomatic infection, associated malignancies, and autoimmune and lymphoproliferative diseases occur. To dissect the evolution of humoral immune responses over the course of EBV infection and to gain a better understanding of the potential contribution of antibody (Ab) …
de, us, ru, nl
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Accès ouvert
2022
article
OpenAlex
Sepideh Dolatshahi, Audrey L. Butler, Christian Pou, Ewa Henckel et autres
Preterm newborns are more likely to suffer from infectious diseases at birth compared to children delivered at term. Whether this is due to compromised cellular, humoral, or organ-specific development remains unclear. To begin to define whether maternal-fetal antibody transfer profiles differ across …
us, se
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Accès ouvert
2022
article
OpenAlex
Kathryn A. Bowman, Daniel Stein, Sally A. Shin, Kathie G. Ferbas et autres
Recent data indicates improved immunity to SARS-CoV-2 in individuals who experience a combination of two mRNA vaccine doses and infection, "hybrid immunity," compared to individuals who receive vaccination or experience infection alone. While previous infection accelerates the vaccine-induced immune response following the …
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Accès ouvert
2022
preprint
OpenAlex
Kathryn A. Bowman, Daniel Stein, Sally A. Shin, Kathie G. Ferbas et autres
ABSTRACT Despite the robust immunogenicity of SARS-CoV-2 mRNA vaccines, emerging data reveal enhanced neutralizing antibody and T cell cross-reactivity among individuals that previously experienced COVID-19, pointing to a hybrid immune advantage with infection-associated immune priming. Beyond neutralizing antibodies and T cell immunity, …
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Accès ouvert
2022
preprint
OpenAlex
Edward B. Irvine, Joshua M. Peters, Richard J. Lu, Patricia S. Grace et autres
ABSTRACT Novel vaccination and therapeutic strategies are urgently needed to mitigate the tuberculosis (TB) epidemic. While extensive efforts have focused on potentiating cell-mediated immunity to control Mycobacterium tuberculosis ( Mtb ) infection, less effort has been invested in exploiting the humoral immune …
us
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Accès ouvert
2022
article
OpenAlex
Marianna Spatola, Carolin Loos, Deniz Cizmeci, Nicholas E. Webb et autres
The central nervous system (CNS) has emerged as a critical HIV reservoir. Thus, interventions aimed at controlling and eliminating HIV must include CNS-targeted strategies. Given the inaccessibility of the brain, efforts have focused on cerebrospinal fluid (CSF), aimed at defining biomarkers of …
us
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Accès ouvert
2022
preprint
OpenAlex
Jonathan D. Herman, Chuangqi Wang, John Stephen Burke, Yonatan Zur et autres
Summary COVID-19 convalescent plasma (CCP), a passive polyclonal antibody therapeutic, has exhibited mixed results in the treatment of COVID-19. Given that the therapeutic effect of CCP may extend beyond the ability of SARS-CoV-2-specific antibody binding and neutralization to influence the evolution of …
us
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Accès ouvert
2022
article
OpenAlex
Paulina Kapłonek, Stephanie Fischinger, Deniz Cizmeci, Yannic C. Bartsch et autres
SARS-CoV-2 mRNA vaccines confer robust protection against COVID-19, but the emergence of variants has generated concerns regarding the protective efficacy of the currently approved vaccines, which lose neutralizing potency against some variants. Emerging data suggest that antibody functions beyond neutralization may contribute …
us
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