Britton Scheuermann

Unimanual fatigue increases muscle excitation and local metabolic activity in the resting contralateral forearm

Lee J. Hinkle, Britton Scheuermann, Carl J. Ade, Thomas J. Barstow et autres

Abstract Intense unilateral muscle contractions evoke measurable activity within the contralateral neuroaxis, which can be detected with surface electromyographic activity in the resting homologous muscle. Physiological mirror activity (PMA), the unintentional increase in contralateral muscle excitation, has been implicated in cross-limb interactions …

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Abstract 4369369: Sex Differences in GLP-1 Receptor Mediated Effects on Exercising Blood Pressure Responses in Peripheral Artery Diseas

Ashley Baranczuk, Britton Scheuermann, Raimi Carroll, Carl J. Ade et autres

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RA) are currently prescribed for diabetes and obesity and may also have beneficial effects for atherosclerotic conditions such as peripheral artery disease (PAD). We recently reported that the GLP-1RA liraglutide (lira) attenuated the exaggerated BP response to …

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Abstract 4360776: Consumption of Eicosapentaenoic Acid Reduces Cardiovascular Mortality Risk in Peripheral Artery Disease Patients

Keith J. Morrison, Sarah Fenn, Carl J. Ade, Britton Scheuermann

Background: Peripheral artery disease (PAD), affects >200 million globally, is linked to reduced quality of life and increased cardiovascular mortality. Standard care emphasizes physical activity, but less is known about nutritional interventions. Studies indicate that eicosapentaenoic acid (EPA), an omega-3 fatty acid, …

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Abstract 4360714: Insights from RNA-Sequencing and Mendelian Randomization in Endometriosis and Cerebral Small Vessel Disease

Sarah Fenn, Keith J. Morrison, Carl J. Ade, Britton Scheuermann

Background: Endometriosis increases risk of cognitive impairment, coagulopathy, and ischemic and hemorrhagic stroke. Endometriosis affects ~10% of reproductive-age women globally, with little known regarding its link to cerebrovascular disease. Cerebrovascular outcomes in endometriosis overlap with those related to cerebral small vessel disease …

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Effects of ageing and exercise training on cerebrovascular vasomotor reactivity, depressive behaviour and the hippocampal transcriptome

Britton Scheuermann, Kathryn Nichol, Cathy W. Levenson, Kiana M. Schulze et autres

The ageing global population is experiencing an increased prevalence of cerebrovascular diseases, such as stroke and dementia. This highlights a need for understanding the pathophysiological mechanisms of age-related cerebrovascular alterations, alongside benefits of interventions such as physical activity. Therefore, our aims were …

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Investigating microvascular outcomes with ischemic preconditioning and passive stretch

Sarah Fenn, Ward C. Dobbs, Maxwell Walker, Britton Scheuermann et autres

Abstract This study examined the effects of intermittent passive stretching (PS) and ischemic preconditioning (IPC) on microvascular responsiveness and muscle oxidative capacity. We hypothesized that PS would lead to greater improvements in vascular function and oxidative capacity than IPC. Eighteen healthy male …

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GLP-1 Receptor Agonism Attenuates the Exaggerated Blood Pressure Response to Exercise in Simulated Peripheral Artery Disease

Ashley Baranczuk, Raimi Carroll, Britton Scheuermann, Carl J. Ade et autres

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), used in the treatment of diabetes and obesity, offer broad antioxidant, anti-inflammatory and cardiovascular benefit. Peripheral artery disease (PAD) is a highly prevalent atherosclerotic vascular disease associated with an exaggerated blood pressure (BP) response to exercise. …

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Bulk and regional diaphragm blood flow during chemical hyperpnea in pulmonary hypertensive rats

Kiana M. Schulze, Andrew G. Horn, Ramona E. Weber, K. Sue Hageman et autres

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Effect of Intermittent Recovery Periods on the Magnitude of the VO2 Slow Component During Heavy Intensity Exercise

Timothy R. Rotarius, Jakob D. Lauver, Britton Scheuermann, Barry W. Scheuermann

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Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction

Stephen T. Hammond, Dryden R. Baumfalk, Shannon K. Parr, Alec L. E. Butenas et autres

5-fluorouracil (5-FU) is the second most common cancer chemotherapy associated with short- and long-term cardiotoxicity. Although the mechanisms mediating these toxicities are not well understood, patients often present with symptoms suggestive of microvascular dysfunction. We tested the hypotheses that patients undergoing cancer …

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Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis

Britton Scheuermann, Shannon K. Parr, Kiana M. Schulze, Olivia Kunkel et autres

Background Cerebral small vessel disease (cSVD) is a major contributing factor to ischemic stroke and dementia. However, the vascular pathologies of cSVD remain inconclusive. The aim of this systematic review and meta‐analysis was to characterize the associations between cSVD and cerebrovascular reactivity …

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Dietary Nitrate Influence on Oxygen Uptake Response to Pseudorandom Binary Sequence Cycling Protocols

Barry W. Scheuermann, Tyler Falor, Andrew Misko, Jordan Monnier et autres

Dietary nitrate supplementation in the form of beetroot juice has been the subject of numerous studies in recent literature with inconclusive results. Beetroot juice (BRJ) has been consistently tested using constant‐load or maximal‐exertion exercise, but the influence of nitrate on pulmonary oxygen …

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