Junlong Zhang

Preclinical evidence and potential mechanisms of tanshinone ⅡA on cognitive function in animal models of Alzheimer’s disease: a systematic review and meta-analysis

Yuanhang Rong, Qinqing Li, Yuzhong Du, Wenting Wang et autres

Background Tanshinone ⅡA (Tan ⅡA) is a monomer extracted from Salvia miltiorrhiza Bunge. Animal studies have demonstrated its potential in providing cognitive protection in Alzheimer’s disease (AD), but the overall effects remain inconclusive, and its multiple mechanisms have not been systematically summarized. …

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Associations of Synaptosome‐associated Protein 25 Gene Polymorphism, Autonomic Nervous System Activity, and Recovery of Consciousness from Propofol Anesthesia

Guang-Chuan Ma, Yueyuan Wang, Jin-Ping Guan, Li Cui et autres

BACKGROUND: The release of synaptic neurotransmitters and function of presynaptic proteins are essential for maintaining nervous system excitation. General anesthesia is a reversible state characterized by the loss of consciousness and reduced responsiveness. This study hypothesized that polymorphisms in one or more …

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Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics

Zhang Zheng, Yousong Zhu, Junlong Zhang, Wenbin He et autres

While genome-wide association studies (GWAS) have identified genetic variants associated with intelligence, their biological mechanisms remain largely unexplored. This study aimed to bridge this gap by integrating intelligence GWAS data with human brain proteomics and transcriptomics. We conducted proteome-wide (PWAS) and transcriptome-wide …

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Study on the role of Dihuang Yinzi in regulating the AMPK/SIRT1/PGC-1α pathway to promote mitochondrial biogenesis and improve Alzheimer's disease

Chao Zhu, Zheng Zhang, Yuzhong Du, Cheng Han et autres

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Effects of Speed, Agility, and Quickness (SAQ) Training on Soccer Player Performance - A systematic review and meta-analysis

Min Sun, Geok Soh Kim, Zhen Shu, Junlong Zhang et autres

Background Previous studies have reported on the impact of Speed, Agility, and Quickness (SAQ) training on the performance of soccer players. However, there is still controversy regarding the results. This systematic review and meta-analysis aim to accurately assess the effects of SAQ …

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Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level

Pulin Liu, Naifei Xing, Zhikai Xiahou, Jingwei Yan et autres

Background: Glioblastoma (GBM), with its high recurrence and mortality rates, makes it the deadliest neurological malignancy. Oxidative phosphorylation is a highly active cellular pathway in GBM, and NFYB is a tumor-associated transcription factor. Both are related to mitochondrial function, but studies on …

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Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship

Yousong Zhu, Qinlong Hui, Zheng Zhang, Hao Fu et autres

Synapses serve as the points of communication between neurons, consisting primarily of three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane. They transmit signals through the release and reception of neurotransmitters. Synaptic plasticity, the ability of synapses to undergo structural and …

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Exercise And/or Metformin Enhances Skeletal Muscle Insulin Sensitivity And Ameliorates Muscle Atrophy In Db/db Mice

Mengqi Xiang, Xinmeng Yuan, Junlong Zhang, Liting Shen et autres

OBJECTIVE PURPOSE: The aims of this study were to investigate the effects of exercise and/or metformin on skeletal muscle atrophy and insulin sensitivity in db/db mice, providing a theoretical basis for the treatment of type II diabetes. METHODS: 8 BKS mice were …

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A rapid and visual detection of Staphylococcus haemolyticus in clinical specimens with RPA-LFS

Tuo Ji, Junlong Zhang, Yuzhi Gao, Cheng Zhao et autres

Staphylococcus haemolyticus (S. haemolyticus), which is highly prevent in the hospital environment, is an etiological factor for nosocomial infections. Point-of-care rapid testing (POCT) of S. haemolyticus is not possible with the currently used detection methods. Recombinase polymerase amplification (RPA) is a novel …

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Functional regulation of syntaxin-1: An underlying mechanism mediating exocytosis in neuroendocrine cells

Xinquan Yang, Weifeng Tu, Xuzhu Gao, Qi Zhang et autres

The fusion of the secretory vesicle with the plasma membrane requires the assembly of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein complexes formed by synaptobrevin, syntaxin-1, and SNAP-25. Within the pathway leading to exocytosis, the transitions between the "open" and "closed" …

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Initiating Continuous Renal Replacement Therapy in Patients With Transurethral Resection of Prostate Syndrome: A Case Report

Dongqin Deng, Qi Zhang, Weifeng Tu, Xinquan Yang et autres

With advances and developments in hysteroscopy, cystoscopy, transurethral resection of bladder tumor, and arthroscopy, transurethral resection of prostate (TURP) syndrome has been increasingly reported. TURP syndrome is often accompanied by severe hyponatremia, fluid overload, and a plasma hypotonic state, resulting in heart …

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Non-Radical Dominated Degradation of Cqp Via Fe-Based O-Doped Polymeric Carbon Nitride Activated Pms: Performance and Mechanism

Zifeng Lin, Ping Chen, Wenying Lv, Zheng Fang et autres

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