Michael Y. He

A 2-in-1 Strategy for the Discovery of Compact HDAC8 Protac Degraders

Yi Liu, Nikee Awasthee, Yufeng Xiao, Seth Hale et autres

Abstract Proteolysis-targeting chimera (PROTAC) technology has emerged as a powerful therapeutic strategy in drug discovery. Conventional PROACs are heterobifunctional molecules composed of two distinct ligands that independently bind to a protein of interest (POI) and an E3 ligase. However, their inherently large …

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Abstract 4602: Dual HDAC3/8 PROTAC degraders exert anti-tumor and immunomodulating effects in diffuse large B-cell lymphoma

Michael Y. He, Yufeng Xiao, Mehran Bakhtiari, Ting Liu et autres

Abstract Critical challenges remain in the clinical management of diffuse large B-cell lymphoma (DLBCL), as up to 40% of patients experience disease relapse or refractoriness. Despite the use of novel therapies, relapsed/refractory DLBCL results in a high risk of mortality, especially in …

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Supplementary Table S2 from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

shRNA sequences that were used to generate HDAC3 KD and the non-targeting control.

Supplementary Methods from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

Supplementary materials and methods.

Supplementary Table S3 from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

Summary of ATAC-seq sequence reads by sample.

Supplementary Figure 3 from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

Cells with HDAC3 loss have increased generation and persistence of DNA DSBs.

Supplementary Figure 2 from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

HDAC3 functional loss radiosensitizes SCLC cell lines.

Data from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

Abstract Small cell lung cancer (SCLC) is an aggressive malignancy, with most patients presenting with prognostically poor extensive-stage disease. Limited progress in standard care stresses the urgent need for novel therapies. Radiotherapy offers some survival benefit for selected patients with SCLC but …

Supplementary Table S1 from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

Detailed information on cell lines and their culture conditions used in this study.

Supplementary Figure 4 from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

The combination of HDAC3 loss and IR improves tumor control in SCLC xenografts.

Supplementary Figure 1 from CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

In vitro CRISPR dropout screen identifies HDAC3 among the top radiosensitizing candidate targets in SCLC.

CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer

Ujas A. Patel, Mary Y. Shi, Jalal M. Kazan, Kevin C. Nixon et autres

Small cell lung cancer (SCLC) is an aggressive malignancy, with most patients presenting with prognostically poor extensive-stage disease. Limited progress in standard care stresses the urgent need for novel therapies. Radiotherapy offers some survival benefit for selected patients with SCLC but could …

ca, de, us (code pays fourni par la source)