Nathan L. Grant

514 Smart Microscopy with Automated ROI Triage Enables 3D Pathology Diagnostic Workflow of Prostate Biopsies: A Multi-Reviewer Validation

Juan C. Santa-Rosario, J. S. Wilson, Paula Rotger Gonzalez, Diana Negrón et autres

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93 3D spatial quantification of CD8+ T-cells in the tumor microenvironment in intact FFPE cancer blocks using the 3D I/O Pro pipeline

Nathan L. Grant, Brandy E. Olin, Alexandra Alvarsson, Jasmine J. Wilson et autres

Background The complexity of the tumor microenvironment (TME) has been a major barrier in understanding the response to therapy in solid tumors. TME analysis has been traditionally based on thin 4 µm tissue sections, which represent less than 0.1% of a typical …

Diagnostic Accuracy of a Custom Large Language Model on Rare Pediatric Disease Case Reports

Cameron C. Young, Ellie Enichen, Christian Rivera, Corinne A. Auger et autres

Accurately diagnosing rare pediatric diseases frequently represent a clinical challenge due to their complex and unusual clinical presentations. Here, we explore the capabilities of three large language models (LLMs), GPT-4, Gemini Pro, and a custom-built LLM (GPT-4 integrated with the Human Phenotype …

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Abstract 2309: 3D spatial quantification of lymphocyte infiltration and collagen features in the tumor microenvironment using a novel assay: 3D I/O Pro™

Caleb R. Stoltzfus, Jasmine J. Wilson, Nathan L. Grant, Alexandra Alvarsson et autres

Abstract Background: The composition of the tumor microenvironment (TME) is a major determinant of response to therapy in many solid tumors. To-date, characterization of the TME has been based on limited analysis of thin tissue sections. Here we demonstrate the utility of …

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Transitioning from pediatric to adult health care in lysosomal diseases: The MPS experience

Nathan L. Grant, Kristin McKay, Susan Shanske, Kim Stephens et autres

1509-H Quantitative assessment of the tumor microenvironment using the Aurora™ 3D Spatial Biology Platform

Caleb R. Stoltzfus, Alexandra Alvarsson, Anna DeWitt, Jasmine J. Wilson et autres

Background Analysis of the three-dimensional (3D) landscape of the tumor microenvironment (TME) has the potential to transform diagnosis and drug development. Current 2D histology techniques introduce sampling error, interobserver variability, and fail to capture the biology contained within the entire tissue. To-date, …

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True Crime: An Interview with George Elliott Clarke

Nathan L. Grant

True Crime: An Interview with George Elliott Clarke Nathan L. Grant (bio) George Elliott Clarke, OC ONS* is one of Canada’s most important literary artists, distinguished in poetry, prose, and drama. An internationally known figure of letters, he has lectured, taught, and …

Quantitative 3D assessment of the lung cancer microenvironment using multi-resolution open-top light-sheet microscopy.

Caleb R. Stoltzfus, Nicholas P. Reder, Alexandra Alvarsson, Anna DeWitt et autres

2616 Background: Non-small cell lung cancer (NSCLC) tissue is a valuable resource for diagnosis, treatment planning, and drug development. Current 2D histopathological techniques introduce under-sampling error (i.e., a single 5 µm section represents 0.5% of a 1 mm thick biopsy), interobserver variability, …

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The impact of COVID-19 on Brazilian children with MPS: Advocate group perspective

Maria Carolina F.A. Oliveira, Brianna D. Yund, Nathan L. Grant, Julie B. Eisengart et autres

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Complex neurocognitive function and quality of life in Morquio and Maroteaux-Lamy syndromes: A longitudinal investigation

Brianna D. Yund, Kyle R. Rudser, Brenda M. Diethelm-Okita, Kelly E. King et autres

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Timing is everything in Hunter syndrome: Differential clinical courses associated with age at initiation of therapy in a sibling pair

Nathan L. Grant, Young Bae Sohn, Norman Matthew Ellinwood, Ericka B. Okenfuss et autres

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Take him home and love him: The experiences of families with Hunter syndrome at home.

Nathan L. Grant