Accès ouvert
2025
article
OpenAlex
Gilda Giancotti, Rhiannon French, Olivia A. Hayward, Kok Yung Lee et autres
The TNF-related apoptosis-inducing ligand (TRAIL) has potential as a therapeutic agent, as it has previously been shown to induce apoptosis in triple-negative breast cancer. However, several studies have demonstrated that patients with tumours develop resistance to TRAIL. We have previously shown that …
gb, cz
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Jaime Calvo Sánchez, Mary T. Scott, Athina Varnava, Tala Alakhras et autres
High expression of the long non-coding RNA (lncRNA) FAM30A has been previously associated with leukemic stem cell (LSC) activity and poor prognosis in both adult and paediatric acute myeloid leukaemia (AML) patients, yet it has not been functionally studied. This study provides …
kr, de, gb
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Gilda Giancotti, Rhiannon French, Olivia A. Hayward, Kok Yung Lee et autres
Abstract The TNF-related apoptosis-inducing ligand (TRAIL) has potential as a therapeutic agent as it has previously been shown to induce apoptosis in triple-negative breast cancer. Recombinant human TRAIL has shown promise in pre-clinical studies of breast cancer. TRAIL exhibits specificity for triple-negative …
gb, cz
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Daniel J. Turnham, William W. Yang, Julia M. Davies, Athina Varnava et autres
A key challenge in the implementation of anti-metastatics as cancer therapies is the multi-modal nature of cell migration, which allows tumour cells to evade the targeted inhibition of specific cell motility pathways. The nuclear factor-kappaB (NF-κB) co-factor B-cell lymphoma 3 (Bcl-3) has …
gb
(code pays fourni par la source)