Eduardo Lopes

The case for primary prevention of obesity in the era of GLP-1 therapies

Soren Holm, Manuel Tena-Sempere, Dimitrios Koutsouris, George V. Dedoussis et autres

Obesity rates continue to rise across Europe, driven by obesogenic environments shaped by food systems, urban design, socioeconomic inequalities, and commercial forces. The introduction of incretin-based pharmacotherapies like GLP-1 receptor agonists has transformed treatment, leading to significant weight loss and metabolic benefits …

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Corrigendum to “The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity” [Mol. Cell. Endocrinol. 594 (2024), 112367]

Daniela Silva, Eduardo Lopes, Tamaeh Monteiro‐Alfredo, Inês Falcão‐Pires et autres

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The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity

Daniela Silva, Eduardo Lopes, Tamaeh Monteiro‐Alfredo, Inês Falcão‐Pires et autres

OBJECTIVE: Obesity is linked to perturbations in energy balance mechanisms, including ghrelin and leptin actions at the hypothalamic circuitry of neuropeptide Y (NPY) and melanocortin. However, information about the regulation of this system in the periphery is still scarce. Our objective was …

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The Bidirectional Relationship of NPY and Mitochondria in Energy Balance Regulation

Diana Sousa, Eduardo Lopes, Daniela Silva, Paulo N. Matafome

Energy balance is regulated by several hormones and peptides, and neuropeptide Y is one of the most crucial in feeding and energy expenditure control. NPY is regulated by a series of peripheral nervous and humoral signals that are responsive to nutrient sensing, …

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