Noemí del‐Toro

IntAct Database for Accessing IMEx's Contextual Metadata of Molecular Interactions

Kalpana Panneerselvam, Pablo Porras, Noemí del‐Toro, Livia Perfetto et autres

The International Molecular Exchange Consortium (IMEx) has evolved into a vital partnership of open resources dedicated to curating molecular interaction data from the scientific literature. This consortium, which includes IntAct, MINT, MatrixDB, and DIP, is a collaborative effort with a central mission …

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Network expansion of genetic associations defines a pleiotropy map of human cell biology

Inigo Barrio‐Hernandez, Jeremy Schwartzentruber, Anjali Shrivastava, Noemí del‐Toro et autres

Interacting proteins tend to have similar functions, influencing the same organismal traits. Interaction networks can be used to expand the list of candidate trait-associated genes from genome-wide association studies. Here, we performed network-based expansion of trait-associated genes for 1,002 human traits showing …

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The IntAct database: efficient access to fine-grained molecular interaction data

Noemí del‐Toro, Anjali Shrivastava, Eliot Ragueneau, Birgit Meldal et autres

The IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of molecular interactions, derived from the scientific literature and from direct data depositions. As of August 2021, IntAct provides more than one million binary interactions, curated by twelve global partners of the …

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Complex Portal 2022: new curation frontiers

Birgit Meldal, Livia Perfetto, Colin Combe, Tiago Lubiana et autres

The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated, encyclopaedic database of macromolecular complexes with known function from a range of model organisms. It summarizes complex composition, topology and function along with links to a large range of domain-specific resources (i.e. wwPDB, EMDB …

gb, it, br, us, fr, nl, de (code pays fourni par la source)

Network expansion of genetic associations defines a pleiotropy map of human cell biology

Inigo Barrio‐Hernandez, Jeremy Schwartzentruber, Anjali Shrivastava, Noemí del‐Toro et autres

Abstract Proteins that interact within molecular networks tend to have similar functions and when perturbed influence the same organismal traits. Interaction networks can be used to expand the list of likely trait associated genes from genome-wide association studies (GWAS). Here, we used …

gb (code pays fourni par la source)

IntAct App: a Cytoscape application for molecular interaction network visualization and analysis

Eliot Ragueneau, Anjali Shrivastava, John H. Morris, Noemí del‐Toro et autres

SUMMARY: IntAct App is a Cytoscape 3 application that grants in-depth access to IntAct's molecular interaction data. It build networks where nodes are interacting molecules (mainly proteins, but also genes, RNA, chemicals…) and edges represent evidence of interaction. Users can query a …

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Analysing the yeast complexome—the Complex Portal rising to the challenge

Birgit Meldal, Carles Pons, Livia Perfetto, Noemí del‐Toro et autres

The EMBL-EBI Complex Portal is a knowledgebase of macromolecular complexes providing persistent stable identifiers. Entries are linked to literature evidence and provide details of complex membership, function, structure and complex-specific Gene Ontology annotations. Data are freely available and downloadable in HUPO-PSI community …

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The Gene Ontology resource: enriching a GOld mine

Seth J Carbon, Eric J. Douglass, Benjamin M. Good, Deepak Unni et autres

The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was …

Towards a unified open access dataset of molecular interactions

Pablo Porras, Elisabet Barrera, Alan James Bridge, Noemí del‐Toro et autres

The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative …

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Analysing the Yeast Complexome - The Complex Portal rising to the challenge

Birgit Meldal, Carles Pons, Livia Perfetto, Noemí del‐Toro et autres

Abstract The EMBL-EBI Complex Portal is a knowledgebase of macromolecular complexes providing persistent stable identifiers. Entries are linked to literature evidence and provide details of complex membership, function, structure and complex-specific Gene Ontology annotations. Data is freely available and downloadable in HUPO-PSI …

gb, es, us (code pays fourni par la source)

Analysing the Yeast Complexome - The Complex Portal rising to the challenge

Birgit Meldal, Carles Pons, Livia Perfetto, Noemí del‐Toro et autres

Datasets of complexes and co-complexes used in the analysis for this paper: Analysing the Yeast Complexome - The Complex Portal rising to the challenge.

gb, es, us (code pays fourni par la source)

Analysing the Yeast Complexome - The Complex Portal rising to the challenge

Birgit Meldal, Carles Pons, Livia Perfetto, Noemí del‐Toro et autres

Datasets of complexes and co-complexes used in the analysis for this paper: Analysing the Yeast Complexome - The Complex Portal rising to the challenge.

gb, es, us (code pays fourni par la source)