Jeffrey K. Giguere

Psychometric Properties of the Generalized Anxiety Disorder Scale (GAD‐7) in Older Adults With Advanced Cancer

Rebecca M. Saracino, Lee Kehoe, Michael B. Sohn, Lu Wang et autres

OBJECTIVES: Over half of new cancer diagnoses occur in patients aged 65 or older, with up to 40% experiencing anxiety. The American Society of Clinical Oncology recommends using the Generalized Anxiety Disorder Scale (GAD-7) for anxiety screening, but the GAD-7 psychometric properties …

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SIOG2024-1-OA-008 Examining completion of patient reported outcomes in a multisite clinical trial by older adults with advanced cancer: implications for future trial design and conduct

Marie Flannery, Z. Zhang, E. Culakova, James D. Bearden et autres

Systemic inflammation and changes in physical well-being in patients with breast cancer: a longitudinal study in community oncology settings

Nikesha Gilmore, Yue Li, Christopher L. Seplaki, Michael B. Sohn et autres

BACKGROUND: Chemotherapy adversely affects physical well-being and inflammation may be related to changes in physical well-being. We evaluated the association of systemic inflammation with changes in physical well-being. METHODS: In a prospective study of 580 patients with stages I-III breast cancer we …

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Life expectancy in older adults with advanced cancer: Evaluation of a geriatric assessment-based prognostic model

Jennifer L. Lund, Paul R. Duberstein, Kah Poh Loh, Nikesha Gilmore et autres

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Psychological predictors of chemotherapy‐induced nausea in women with breast cancer: Expectancies and perceived susceptibility

Elise J. Devlin, Hayley S. Whitford, Anita R. Peoples, Gary R. Morrow et autres

OBJECTIVE: Chemotherapy-induced nausea is challenging to predict and treat. Research indicates that pretreatment psychological variables including patients' perceptions of their susceptibility to nausea, expectancies of treatment-related nausea and nausea history (i.e., motion sickness, morning sickness and baseline levels of nausea) may aid …

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Prevalence of and factors associated with treatment modification at first cycle in older adults with advanced cancer receiving palliative treatment

Mostafa Mohamed, Kaitlin Kyi, Supriya G. Mohile, Huiwen Xu et autres

INTRODUCTION: Treatment toxicities are common in older adults with cancer and consequently, treatment modifications are sometimes considered. We evaluated the prevalence and factors associated with treatment modifications at the first cycle in older patients receiving palliative systemic treatment. METHODS: Patients (n = …

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Association of changes of pro-inflammatory markers with physical function in women with breast cancer receiving chemotherapy.

Nikesha Gilmore, Elizabeth Belcher, Po‐Ju Lin, Amber S. Kleckner et autres

562 Background: Chemotherapy adversely affects the immune system and physical function. Inflammation is independently associated with functional decline. Compared to the individual cytokines [e.g., interleukin-6 (IL-6)], the pro-inflammatory index, IL-6/IL-10 ratio, is a better predictor of poor outcomes and mortality in many …

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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

M.C. Liu, Geoffrey R. Oxnard, Eric A. Klein, Charles Swanton et autres

BACKGROUND: Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation analysis of circulating cell-free DNA (cfDNA) to detect and …

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Improving person-centered communication of goals, proxy, and advance directives in older patients with advanced cancer: Secondary analysis from a University of Rochester NCI Community Oncology Research Program (NCORP) cluster randomized controlled trial (CRCT).

Marie Flannery, Eva Culakova, Kah Poh Loh, Ronald M. Epstein et autres

11523 Background: Quality person-centered care relies on effective communication between the clinical team and the patient/caregiver eliciting goals and discussing wishes. In a PCORI- and NCI-funded CRCT, we found that providing community-based oncologists with geriatric assessment-guided recommendations led to more and higher …

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Longitudinal Relationship Between Frailty and Cognition in Patients 50 Years and Older with Breast Cancer

Allison Magnuson, Lianlian Lei, Nikesha Gilmore, Amber S. Kleckner et autres

OBJECTIVES: To evaluate relationships between frailty and cognition longitudinally in adults 50 years and older with breast cancer receiving chemotherapy. DESIGN: Secondary analysis of a prospective longitudinal observational study. SETTING: University of Rochester NCI Community Oncology Research Program community oncology clinics. PARTICIPANTS: …

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Associations of inflammation with frailty in patients with breast cancer aged 50 and over receiving chemotherapy

Nikesha Gilmore, Sindhuja Kadambi, Lianlian Lei, Kah Poh Loh et autres

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Abstract P6-20-07: Efficacy and safety of CB-839, a small molecule inhibitor of glutaminase, in combination with paclitaxel in patients with advanced triple negative breast cancer (TNBC): Initial findings from a multicenter, open-label phase 2 study

Gregory A. Vidal, Kevin Kalinsky, Erica Stringer-Reasor, Filipa Lynce et autres

Abstract Background: CB-839 is an investigational first-in-class, potent, oral inhibitor of glutaminase (GLS), a mitochondrial enzyme that controls a critical step in tumor cell utilization of glutamine. TNBC is associated with high GLS expression and depends on GLS conversion of glutamine to …

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