Mostafa Mohamed

Treatment Tolerability in Older Adults With Advanced Cancer Receiving Geriatric Assessment–Guided Versus Oncologist-Guided Primary Treatment Modification: Secondary Analysis of the GAP70+ Trial

Mostafa Mohamed, D Q Rich, Jennifer L. Lund, Christopher L. Seplaki et autres

PURPOSE: Primary treatment modification (PTM; changes in treatment dose or agents from standard guidelines) is common among older adults with advanced cancer because of aging-related vulnerabilities. Geriatric assessment evaluates aging-related factors to inform personalized treatment. We compared treatment tolerability between PTM guided …

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Abstract 6303: Designing an integrative theoretical framework for predicting endocrine toxicity in a large prospective cohort of cancer patients treated with immune checkpoint inhibitor therapy

Hala Awad, Mostafa Mohamed, Michelle C. Janelsins, Jeremy McGuire et autres

Abstract Immune checkpoint inhibitors (ICI) are associated with immune-related adverse events (irAEs) involving the endocrine system. The rate of endocrine irAEs can vary significantly depending on the agent used, with an average all-grade occurrence of 23% and a severe-grade occurrence of 19%. …

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Outcomes of Older Adults With Advanced Cancer Who Prefer Quality of Life vs Prolonging Survival

Daniel R. Richardson, Ying Wang, Marie Flannery, Mostafa Mohamed et autres

Importance: Health care systems should strive to achieve outcomes that matter to patients. Limited data exist on the outcomes achieved by patients with cancer with different treatment outcome preferences. Objective: To describe treatment outcome preferences among older adults with advanced cancer and …

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Comparison of the prevalence of patient-reported and clinician-graded cognitive symptomatic adverse events in older patients with advanced cancer

R. Alieldin, Mostafa Mohamed, Chiang‐Shan R. Li, M. Janelsins et autres

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Patient-reported symptom burden and cognitive decline in older adults with lymphoma undergoing chemotherapy: Impact of disease stage

Mostafa Mohamed, K.P. Loh, Umang Gada, A. Magnuson et autres

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Longitudinal assessment of cognitive function in patients with breast cancer and lymphoma receiving chemotherapy

Hongying Sun, Umang Gada, R. Alieldin, Hannah Teets et autres

BACKGROUND: Cancer-related cognitive impairment is a significant concern, yet data assessing long-term changes from pretreatment baselines are limited. METHODS: In this large nationwide study, patients with breast cancer and lymphoma and controls were assessed at pre-chemotherapy, post-chemotherapy, 6-month, 1-year, and 2-year follow-ups. …

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Cost-Utility of Geriatric Assessment and Management in Older Adults With Cancer: Model-Based Economic Evaluation

Selai Akseer, Shant Torkom Yeretzian, Lusine Abrahamyan, Martine Puts et autres

PURPOSE: Geriatric assessment and management (GAM) is a guideline-recommended strategy for optimizing cancer management among older adults. A recent cost-utility analysis of the Canadian 5C randomized controlled trial (RCT) found GAM to be cost effective for selected groups. This study aimed to …

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Decision regret in older adults with advanced cancer receiving systemic therapy: Associations with patient‐reported and clinician‐rated tolerability metrics

Marie Flannery, Zhihong Zhang, Eva Culakova, Kah Poh Loh et autres

BACKGROUND: Decision regret (DR) (distress or remorse after a treatment decision) has received limited examination in older adults with advanced cancer. The authors hypothesized that DR would change over time and be associated with worse patient-reported outcomes (PRO) and clinician-rated tolerability metrics …

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Advancing the Identification of High-Risk Medications in Older Adults With Cancer

Mostafa Mohamed, Erika Ramsdale

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Effect of the DASH diet on health outcomes and cost of managing hypertension in Egyptian adults: A Randomized controlled trial

Reham Salah Amin Radwan, Mostafa Mohamed, Manal M. Anwar, Tamer Hifnawy et autres

Background: Hypertension, a major cardiovascular risk factor, is highly prevalent in Egypt (26.3%), leading to significant morbidity, mortality, and economic burdens. The DASH diet—rich in fruits, vegetables, and low-fat dairy—effectively lowers blood pressure, improves cardiometabolic health, and is cost-effective compared to pharmacotherapy. …

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Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer

Surbhi Singhal, Ying Wang, Richard F. Dunne, Lee Kehoe et autres

BACKGROUND: Nutritional impairment is common among older adults with advanced cancer. The association between baseline nutritional impairment and the trajectory of quality of life (QOL) and psychological health among patients receiving palliative cancer treatment is not known. METHODS: 11. The Functional Assessment …

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How to make recommendations on dosing for older adults receiving systemic cancer treatment – A holistic and pragmatic approach to decision-making with a focus on colorectal cancer

Gábor Liposits, Konstantinos Christofyllakis, Luca Tondulli, Mostafa Mohamed

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