Gunnar A. Rau

Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt, Markus Hufnagel, Natalie Diffloth, Johannes Hübner et autres

By means of a nationwide, prospective, multicenter, observational cohort registry collecting data on 7375 patients with laboratory-confirmed SARS-CoV-2 admitted to children's hospitals in Germany, March 2020-November 2022, our study assessed the clinical features of children and adolescents hospitalized due to SARS-CoV-2, evaluated …

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Discordancy for Placental Massive Perivillous Fibrin Deposition and Fetal Growth in Dichorionic Twins after in Vitro Fertilization

Henning Feist, Thordes Blöcker, Gunnar A. Rau, Kais Hussein

Massive perivillous fibrin deposition (MFD) is a placental lesion of unknown etiology associated with perinatal morbidity and mortality and recurrence risk in subsequent pregnancies. We report a 34 weeks' gestation dizygotic twin pregnancy with discordancy for MFD and for intrauterine growth restriction …

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Portal Venous Gas Detected by Ultrasound Differentiates Surgical NEC from Other Acquired Neonatal Intestinal Diseases

Bettina Bohnhorst, Joachim F. Kuebler, Gunnar A. Rau, S. Glüer et autres

BACKGROUND: The definite clinical diagnosis of acquired neonatal intestinal diseases (ANID) is a challenge, usually met by applying Bell's or, more recently, Gordon's classification. Both classifications incorporate radiological pneumatosis intestinalis (PI) as a cornerstone of the NEC diagnosis. However, PI may be …

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Developmental physiology of human surfactant phosphatidylcholine – Intrauterine changes relative to prenatal glucocorticoids (PNG), respiratory distress (RDS) and bronchopulmonary dysplasia (BPD)

S. Luce, Gunnar A. Rau, Grielof Koster, CS Peter et autres

Aims: Surfactant is a complex comprising phosphatidylcholine (PC), phosphatidylglycerol and specific proteins in variable concentrations. Dipalmitoyl-PC (DPPC), palmitoyl-myristoyl-PC (PMPC) and palmitoyl-palmitoleoyl-PC (PPPC) are enriched during surfactant assembly, while other PCs are mainly retained in cells. Particularly, PMPC may be immunologically important (1). …

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Evaluation of portal venous gas detected by ultrasound examination for diagnosis of necrotising enterocolitis

Michael Dördelmann, Gunnar A. Rau, Daniela Bartels, Manfred Linke et autres

BACKGROUND: Early diagnosis of necrotising enterocolitis (NEC) is difficult but essential for timely therapy. The diagnostic hallmarks and specific radiological signs for NEC are pneumatosis intestinalis (PI) and portal venous gas (PVG), but PVG in abdominal ultrasound (PVG-US) has been proposed as …

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Molecular and functional changes of pulmonary surfactant in response to hyperoxia

Heike Dombrowsky, Thomas Tschernig, Gertrud Vieten, Gunnar A. Rau et autres

Surfactant comprises phosphatidylcholine (PC) together with anionic phospholipids, neutral lipids, and surfactant proteins SP-A to-D. Its composition is highly specific, with dipalmitoyl-PC, palmitoyl-myristoyl-PC, and palmitoyl-palmitoleoyl-PC as its predominant PC species, but with low polyunsaturated phospholipids. Changes in pulmonary metabolism and function in …

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Antenatal Ultrasonographic Appearance of Isolated Fetal Ascites

I. Staboulidou, Jenna Schauer, Gunnar A. Rau, Ralf Hass et autres

BACKGROUND: Isolated fetal ascites can be caused by many heterogeneous disorders and is associated with a variety of conditions. Cloacal anomalies are rare abnormalities with a highly variable array of sonographic symptoms, which make them difficult to diagnose antenatally. We present a …

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Acknowledgement to the Reviewers

Zdeněk Žižka, J. Schauer, Evangelos Paraskevaidis, Ioanna Bouba et autres

Subject Index Vol. 21, 2006

Zdeněk Žižka, J. Schauer, Evangelos Paraskevaidis, Ioanna Bouba et autres

Activin A concentration 156 Adrenocorticotropin 528 Aicardi-Goutières syndrome 153 Alloimmune thrombocytopenia 55 Alloimmunization 22, 269 Alveolar count 39 Amiodarone 72 Amniocentesis 287, 326 Amnion cell 494 Amnioreduction 302 Amniotic band syndrome 255 -fluid 148, 287 --cells 118 Anal atresia 383 Anamnestic risk …

Author Index Vol. 21, 2006

Zdeněk Žižka, J. Schauer, Evangelos Paraskevaidis, Ioanna Bouba et autres

Surfactant from diving aquatic mammals

Roger G. Spragg, Paul J. Ponganis, James J. Marsh, Gunnar A. Rau et autres

Diving mammals that descend to depths of 50-70 m or greater fully collapse the gas exchanging portions of their lungs and then reexpand these areas with ascent. To investigate whether these animals may have evolved a uniquely developed surfactant system to facilitate …

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Mass Spectrometric Analysis of Surfactant Metabolism in Human Volunteers Using Deuteriated Choline

Wolfgang Bernhard, Christopher J. Pynn, Andreas Jaworski, Gunnar A. Rau et autres

Surfactant reduces surface tension at pulmonary air-liquid interfaces. Although its major component is dipalmitoyl-phosphatidylcholine (PC16:0/16:0), other PC species, principally palmitoylmyristoyl-PC, palmitoylpalmitoleoyl-PC, and palmitoyloleoyl-PC, are integral components of surfactant. The composition and metabolism of PC species depend on pulmonary development, respiratory rate, and …

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