Accès ouvert
2026
article
OpenAlex
Marie Attwood, Tamara Choola, Erin Duffy, Valeria Gigante et autres
spp. are among the most common causative bacterial pathogens, however, their burden and rates of antimicrobial resistance (AMR) are poorly quantified. Current treatment typically involves oral and intravenous rehydration fluids, nutritional support for malnourished children, antibiotics for severe bacterial infections, antiemetic and …
gb, us, ch, nl, cl, fr, sg, Ghana
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2026
article
OpenAlex
Benoît Courbon, Chloé Madras, Louis Thibon, Hélène Dugua et autres
We propose an innovative technology based on the combination of Raman microspectroscopy and deep learning to classify the Mechanism of Action (MoA) of antimicrobials and predict their novelty. Raman microspectroscopy provides chemical and physical signatures of molecular structures in bacteria to reveal …
fr
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Accès ouvert
2025
preprint
OpenAlex
Francisco Olmo, Amy Hesketh, Hayat Hage, Jean‐Marc Monneuse et autres
Abstract Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi. Despite triggering a strong immune response, infections are typically life-long and can result in severe cardiac and/or digestive tract pathology. Current drugs have limited efficacy, and treatment failure is …
es, fr, gb, ch
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Accès ouvert
2025
article
OpenAlex
Zohreh Sedaghat, Benoît Courbon, Héloïse Botrel, Hélène Dugua et autres
We propose an innovative technology to classify the Mechanism of Action (MoA) of antimicrobials and predict their novelty, called HoloMoA. Our rapid, robust, affordable and versatile tool is based on the combination of time-lapse Digital Inline Holographic Microscopy (DIHM) and Deep Learning …
fr
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Accès ouvert
2025
article
OpenAlex
Andrés Ceballos-Garzón, Julien Lebrat, Marion Holzapfel, Diego Fernando Josa et autres
ABSTRACT This study comprehensively assessed the activity of manogepix (MNGX), ibrexafungerp (IBF), amphotericin B (AMB), rezafungin (RZF), and caspofungin (CAS) against planktonic cells and mature biofilms of Candida spp.—reference and clinical strains using the Calgary biofilm device. Mature-phase biofilms of C. albicans …
fr, co
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Accès ouvert
2025
article
OpenAlex
Andrés Ceballos-Garzón, Marion Holzapfel, Jo Anne Welsch, Derry K. Mercer
Abstract Objectives The aim of this study was to identify and determine the MICs of 13 antifungal drugs, including the novel agents ibrexafungerp, manogepix and rezafungin, against 22 laboratory reference strains from 14 different Candida spp. and allied yeast genera using the …
fr, co
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Zohreh Sedaghat, Benoît Courbon, Héloïse Botrel, Hélène Dugua et autres
ABSTRACT We propose an innovative technology to classify the Mechanism of Action (MoA) of antimicrobials and predict their novelty, called HoloMoA. HoloMoA is a rapid, robust, inexpensive, and versatile tool based on the combination of time-lapse Digital Inline Holographic Microscopy (DIHM) and …
fr
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Orla Lappin, Sarah Jenner, Amanda Marie James, Derry K. Mercer
As part of its policy activity, the Society has issued several position statements on issues relevant to the molecular biosciences and the broader science sector. These statements outline the Society’s stance on these important topics and underscore activity and engagement across the …
gb, us, fr
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Accès ouvert
2023
article
OpenAlex
Douglas J. Fraser-Pitt, Derry K. Mercer, Marie-Louise R. Francis, David Toledo-Aparicio et autres
Transient blockade of glycine decarboxylase (GLDC) can restrict de novo pyrimidine synthesis, which is a well-described strategy for enhancing the host interferon response to viral infection and a target pathway for some licenced anti-inflammatory therapies. The aminothiol, cysteamine, is produced endogenously during …
gb, fr
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Accès ouvert
2023
article
OpenAlex
Tailise de Souza Guerreiro Rodrigues, Anthony Maxwell, Derry K. Mercer, Orla Lappin
Part of the Biochemical Society’s mission is to champion the molecular biosciences and their importance in addressing societal grand challenges. To achieve this, the Society undertakes policy work, aiming to channel the views of its membership and community to policy makers.As part …
gb, fr
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Accès ouvert
2021
article
OpenAlex
Douglas J. Fraser-Pitt, Stephen K. Dolan, David Toledo-Aparicio, Jessica G. Hunt et autres
Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less virulent over time, but often …
gb, dk
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2021
article
OpenAlex
Derry K. Mercer, Marie-Louise R. Francis, Douglas J. Fraser-Pitt
In this age of antimicrobial resistance (AMR) there is an urgent need for novel antimicrobials. One area of recent interest is in developing antimicrobial effector molecules, and even cell-based therapies, based on those of the immune system. In this review, some of …
gb
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