Maranke I. Koster

A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders

Maddison N. Salois, Saiphone Webb, Isaiah A. Proctor, Peter J. Koch et autres

Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) is a disorder caused by autosomal-dominant mutations in the TP63 gene. AEC is characterised by the presence of severe and painful skin erosions that can take years to heal. Current treatment options for these devastating lesions are limited, …

us (code pays fourni par la source)

Complex Wounds in Ectodermal Dysplasias: Translating Discovery to Therapy

Mary D. Fete, Becky M. Abbott, Maddison N. Salois, Shirley P. Parraga et autres

The "Complex Wounds in Ectodermal Dysplasias: Translating Discovery to Therapy" conference aimed to accelerate the development of novel treatments for complex wounds in ectodermal dysplasias. The conference brought together leading experts in keratinocyte biology, wound healing, and clinical care to explore the …

us (code pays fourni par la source)

0561 Different molecular mechanisms underlie skin fragility in AEC and EEC

Maddison N. Salois, Sherry S. Webb, S.R. Price, Maranke I. Koster

397 A novel model system to identify molecular defects underlying impaired keratinocyte-ECM adhesion in AEC

Maddison N. Salois, Saiphone Webb, Maranke I. Koster

us (code pays fourni par la source)

Immunohistochemical and Histopathological Characterization of Spina Bifida Defect Tissues Removed After Prenatal and Postnatal Surgical Repair

James R. Bardill, Melissa Ronni Laughter, Jaclyn B. Anderson, Hilary Hoffman et autres

Background: Myelomeningocele or spina bifida is an open neural tube defect that is characterized by protrusion of the meninges and the spinal cord through a deformity in the vertebral arch and spinous process. Myelomeningocele of post-natal tissue is well described; however, pre-natal …

us (code pays fourni par la source)

41818 Immunohistochemical and Histopathological Characterization of Spina Bifida Defect Skin After Prenatal and Postnatal Repair

Melissa Ronni Laughter, James R. Bardill, Jaclyn B. Anderson, Hilary Hoffman et autres

us (code pays fourni par la source)

Effects of TP63 mutations on keratinocyte adhesion and migration

Maddison N. Salois, Jessica A. Gugger, Saiphone Webb, Christina E. Sheldon et autres

The goal of this study was to investigate the molecular mechanisms responsible for the formation of skin erosions in patients affected by Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC). This ectodermal dysplasia is caused by mutations in the TP63 gene, which encodes several transcription …

us (code pays fourni par la source)

Effects of TP63 Mutations on Keratinocyte Adhesion and Migration

Maddison N. Salois, Jessica A. Gugger, Saiphone Webb, Christina E. Sheldon et autres

The goal of this study was to investigate the molecular mechanisms responsible for the formation of skin erosions in patients affected by Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC). This ectodermal dysplasia is caused by mutations in the TP63 gene, which encodes several transcription …

us (code pays fourni par la source)

Supplementary Figures 1-15 from Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling

Senthilnath Lakshmanachetty, Velmurugan Balaiya, Whitney A. High, Maranke I. Koster

S1. TP63 expression is downregulated in late-stage human larynx HNSCCs. S2. Histopathological analysis of mouse tongue SCCs. S3. TP63 and KRT14 (epithelial marker) expression is lost in a subset of human HNSCC cell lines. S4. Loss of TP63 in HNSCC cell lines …

Data from Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling

Senthilnath Lakshmanachetty, Velmurugan Balaiya, Whitney A. High, Maranke I. Koster

Abstract TP63 is frequently amplified or overexpressed in primary head and neck squamous cell carcinomas (HNSCC). Nevertheless, the role of TP63 in the initiation and progression of HNSCCs is not known. Using archival HNSCC tissue sections, we found that TP63 expression is …

Supplementary Figures 1-15 from Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling

Senthilnath Lakshmanachetty, Velmurugan Balaiya, Whitney A. High, Maranke I. Koster

S1. TP63 expression is downregulated in late-stage human larynx HNSCCs. S2. Histopathological analysis of mouse tongue SCCs. S3. TP63 and KRT14 (epithelial marker) expression is lost in a subset of human HNSCC cell lines. S4. Loss of TP63 in HNSCC cell lines …

Supplementary Table 1 from Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling

Senthilnath Lakshmanachetty, Velmurugan Balaiya, Whitney A. High, Maranke I. Koster

Table S1. Significantly differentially expressed genes in TP63 knockdown SCCs compared to NS shRNA SCCs.