Yan Long

CAMP-negative group B Streptococcus in pregnant women: molecular and clinical features with implications for diagnostics and neonatal management

Lianfen Huang, Zeying Lin, Sufei Zhu, Chengman Fong et autres

The Christie-Atkins-Munch-Peterson (CAMP) test and cfb -targeted polymerase chain reaction (PCR) are widely used for identification of Streptococcus agalactiae (Group B Streptococcus , GBS). However, CAMP-negative strains may evade detection. This study aimed to characterize antimicrobial resistance, molecular profiles, and pregnancy outcomes …

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Invasive Streptococcus agalactiae Infections in Infants in Guangzhou, Southern China (2013-2022): Molecular Epidemiology and Clinical Management Implications

Xiaolan Chen, Huamin Zhong, Y. G. Xie, Wenshan Chen et autres

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Reduction of regulatory B cells is associated with high-risk clinical stratification in antiphospholipid syndrome patients

Rui Ma, Y. Wang, Jing-hong Feng, Wen-yi Li et autres

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Nanotube-oxygen vacancy synergy for electron-rich Ru nanoparticles towards efficient H2 evolution

Xingyu Wan, Song Wu, Shaoxian Song, Guangyin Fan et autres

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Elevated pre-pregnancy testosterone is associated with gestational diabetes mellitus: an observational cohort study

Xi Luo, Meng Li, Yan Long, Chunmei Ying et autres

Context: Pre-pregnancy testosterone increase may be closely related to the occurrence of gestational diabetes mellitus (GDM). Objective: Our aim is to explain the relationship between pre-pregnancy testosterone levels and the risk of GDM and provide evidence for early clinical warning. Methods: We …

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1422P A single-center, observational, phase II clinical study of PD-1 inhibitor or cetuximab combined with chemotherapy for neoadjuvant treatment of recurrent, resectable head and neck squamous cell carcinoma

Linhua Tan, Hui Zhang, Wentao Huang, Zhe Wang et autres

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ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP–Wnt pathway

Qian Luo, Yijin Chen, Honghu Li, Yan Long et autres

Human embryonic stem cells (hESCs) serve as an ideal cell source for generating hematopoietic stem cells (HSCs). In embryonic hematopoiesis, hemogenic endothelium has been identified as a source of HSCs, yet the regulatory mechanisms remain elusive. Here, through dynamic gene expression profiling …

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Identification of Loci and Candidate Genes Associated with Arginine Content in Soybean

Qing Ping Yang, Cuihong Yu, Zhi Xin Liu, Xiaolei Shi et autres

Soybean (Glycine max) seeds are rich in amino acids, offering key nutritional and physiological benefits. In this study, 290 soybean accessions from the USDA Germplasm Collection based in Urbana, IL Information Network (GRIN) were analyzed. Four Genome-Wide Association Study (GWAS) models—Bayesian-information and …

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Network Pharmacology Combined with Proteomics Reveals That 3-Acetyl-11-keto-β-boswellic Acid Inhibits the Progression of Prostate Cancer by Regulating the IL-17 Signaling Pathway

Bo Zou, Qizhi Liu, Yan Long, Xinjun Dai et autres

BACKGROUND: 3-acetyl-11-keto-beta-boswellic acid (AKBA) is a monomer extracted from the traditional Chinese herbs of Boswellia that has antitumor effects. However, the therapeutic effects and mechanisms of AKBA in prostate cancer (PCa) are unclear. OBJECTIVE: To predict the target of AKBA treatment of …

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Harnessing biotechnology to promote the utilization of crop heterosis

Wei Xun, Ziwen Li, Zhenying Dong, Juan Zhang et autres

杂种优势是现代作物改良的重要理论与技术基础，其利用推动了农业生产力的显著提升。生物技术与育种技术的快速发展和融合，极大地丰富了杂种优势的研究手段与应用深度。本研究以第一届“第一届全国作物杂种优势与生物育种学术大会”报告为基础，系统综述了作物杂种优势与生物育种的研究进展，回顾了作物杂种优势机理解析、杂种优势利用技术的发展历史，探讨了作物生殖发育与雄性不育机制研究及其在杂种优势利用中的作用。重点总结了决定作物产量、生产效率以及调控胁迫条件下作物生长发育等重要性状的关键基因。分析了基因组解析在生物育种中的应用实践，以及基因编辑、合成生物学等现代生物育种技术的集成化与应用推广对提升育种效率的深远影响。此外，本文还阐明了通过提高种子质量、提高育种区域特异性以及提高育种主体水平等方面发展作物种业新质生产力的路径。最后，提出解析杂种优势形成的分子机制、释放基因编辑技术应用潜力、利用人工智能和大数据技术优化生物育种范式、关注环境适应性气候变化对育种工作的影响等是未来作物杂种优势与生物育种研究的发展方向，以期为保障粮食安全、农业可持续发展提供理论研究与技术应用的参考。

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Identification of Loci and Candidate Genes Associated with Arginine Content in Soybean

Qing Yang, Cuihong Yu, Zhi Xin Liu, Xiaolei Shi et autres

Soybean (Glycine max) seeds are rich in amino acids, offering key nutritional and physiological benefits. In this study, 290 soybean accessions from the USDA-ARS Germplasm Resources Information Network (GRIN) were analyzed. Four genome-wide association study (GWAS) models—Bayesian-information and Linkage-disequilibrium Iteratively Nested Keyway …

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Landscape of rare‐allele variants in cultivated and wild soybean genomes

Zhi Liu, Xiaolei Shi, Qing Yuan Yang, Ying Li et autres

Rare-allele variants are important for crop improvement because they can be linked to important traits. However, genome-wide distribution and annotation of rare-allele variants have not been reported. We analyzed sequencing data from 1556 soybean accessions and found 6,533,419 rare-allele variants in Glycine …

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