О. А. Беркович

Genetic architecture of familial hypercholesterolemia: a cohort of St. Petersburg residents

В. В. Мирошникова, Artem D. Izyumchenko, M. V. Muzalevskaya, K. V. Legostaeva et autres

Aim. To determine the frequency of pathogenic and likely pathogenic variants associated with familial hypercholesterolemia (FH) with assessment of the proportion of polygenic FH according to the 6-SNP genetic risk score (GRS) among patients diagnosed with possible/probable/definite FH in St. Petersburg. Material …

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Decreased DNA methyltransferase 1 level in blood cells in Parkinson’s disease

Anna O. Lavrinova, E. M. Litusova, P A Gagarina, Alexey Alexandrovich Dmitriev et autres

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Variants of the vitamin D receptor gene and the expression of microRNA‑21, microRNA‑125a, microRNA‑125b and microRNA‑214 in coronary heart disease

Ж. И. Ионова, О. А. Беркович, О. D. Belyaeva, Михаил Игоревич Зарайский

Background. The protective effects of vitamin D in relation to atherogenesis are realized by vitamin D receptors (VDR). Variants rs10735810, rs731236, rs1544410 and rs797532 of the VDR gene are involved in regulating the stability of its mRNA. МicroRNA‑214, microRNA‑125a, microRNA‑125b and microRNA‑21 …

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Predictors of unfavorable prognosis in patients with coronary artery disease

Д. А. Колодина, О. D. Belyaeva, О. А. Беркович, V. E. Larionova

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Serum expression of microRNA-21, microRNA-125a, microRNA-125b, microRNA-214 in coronary artery disease patients

Ж. И. Ионова, О. А. Беркович, О. D. Belyaeva, Михаил Игоревич Зарайский et autres

Background. Coronary artery disease (CAD) is determined by interaction of environmental factors with epigenetic and genetic factors. MicroRNA-21, microRNA-125a, microRNA-125b and microRNA-214 are small non-coding RNAs and the most important regulators of gene expression. MicroRNA-21, -125a, -125b and -214 are insufficiently studied …

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Vitamin D Deficiency Impairs Post-Infarction Left Ventricular Remodeling in Rats

Ж. И. Ионова, А. А. Карпов, О. А. Беркович, S. G. Cefu et autres

Abstract Coronary Heart Disease (CHD) is a multifactorial pathology whose progression is associated with the development of chronic heart failure (CHF) following myocardial infarction (MI). Recent studies have shown that vitamin D deficiency is an independent risk factor for CHD and its …

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Экспрессия микроРНК-21 в плазме крови и в миокарде правого предсердия у больных ишемической болезнью сердца, перенесших коронарное шунтирование

Д. А. Колодина, О. Д. Беляева, О. А. Беркович, Е.А. Полякова et autres

Актуальность Ишемическая болезнь сердца (ИБС) занимает лидирующую позицию среди причин смертности во всем мире. Сохраняется необходимость поиска новых эпигенетических маркеров, определяющих риск и прогноз ИБС. Цель Оценить уровень экспрессии микроРНК-21 в крови и в миокарде правого предсердия у больных ИБС, перенесших коронарное …

Infective endocarditis: complications, clinical features in various population groups, treatment, prevention. Literary review

О. N. Zhdanova, О. А. Беркович, О. D. Belyaeva

The literature review presents an analysis of domestic and foreign publications, modern clinical guidelines for infective endocarditis. Based on the analysis of literature data, the main directions of examination of patients with infective endocarditis, including complicated forms of the disease, were determined. …

Infective endocarditis: epidemiology, etiology, clinic (modern aspects). Literary review

О. А. Беркович, О. D. Belyaeva, О. N. Zhdanova

The literature review presents an analysis of domestic and foreign publications, modern clinical recommendations for infective endocarditis. Based on the analysis of literature data, a change in the structure of pathogens of infective endocarditis was established, where Staphylococcus aureus occupies the leading …

ЭКСПРЕССИЯ ГЕНОВ МИКРОРНК-21, МИКРОРНК-125А, МИКРОРНК-125B И МИКРОРНК-214 В ПЛАЗМЕ КРОВИ БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА С ОЖИРЕНИЕМ И РАЗЛИЧНОЙ ОБЕСПЕЧЕННОСТЬЮ 25(ОН)D

О. А. Беркович, Ж. И. Ионова, М. И. Зарайский

Omentin-1 and Coronary Heart Disease

Д. А. Колодина, A. S. Draganova, О. D. Belyaeva, О. А. Беркович

Aim. The purpose of the review is to summarize the results of studies on the relationship between the level of omentin-1 and coronary artery disease (CAD). Key points. Adipose tissue is currently considered as an endocrine organ synthesizing biologically active factors known …

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rs2290201 and rs16909192 variants of the fatty acid binding protein 4 (FABP4) gene in patients with coronary artery disease who underwent coronary artery bypass grafting

Д. А. Колодина, О. D. Belyaeva, О. А. Беркович, Ekaterina A Polyakova et autres

Aim. To determine the distribution of genotypes and the allele frequency of rs2290201 and rs16909192 variants of the fatty acid binding protein 4 gene (FABP4), to compare the concentration of fatty acid binding protein 4 (FABP4) in blood serum, lipid metabolism and …

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