Dilek Akakın

Epidural Electrical Stimulation Within an Integrated Rehabilitation Pathway for Traumatic Cervical Spinal Cord Injury: Safety and 12-Month Functional Outcomes

Arzu Dinç Yavaş, A. Cevik, Emir Eker, Seyma Sarioglu et autres

Background/Objectives: Epidural electrical stimulation (EES) is an investigational, off-label neuromodulation strategy used adjunctively with rehabilitation in chronic spinal cord injury (SCI), but safety and longitudinal functional data specific to traumatic cervical SCI remain limited. This is a descriptive safety-and-feasibility study, not an …

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Dose-dependent neurotoxic effects of monosodium glutamate on neural tube development in chicken embryos

Eylem Burcu Kahraman Özlü, Dila Şener Akçora, Ezgi Akar, Dilek Akakın et autres

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Postmortem Evaluation of Topoisomerase IIβ, Nurr1, and Neuroinflammatory Signatures in Parkinson's Disease

Mahdis Taghavibayat, Dilek Akakın, Bercem Yaman Kiyak, Sevim Işık

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Investigation of the Effects of Hypothyroidism Duration on Hearing Function: An Experimental Animal Study

Arzu Tatlıpınar, Ahmet Kutluhan, Mustafa Bülent Şerbetçioğlu, Dilek Özbeyli et autres

Objective: Congenital hypothyroidism is well known to impair auditory development and function. However, the effect of acquired hypothyroidism, particularly regarding its duration, has not been clearly defined. Data investigating the relationship between prolonged hypothyroidism and hearing remain scarce. This experimental study aimed …

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Evaluation of the neuroprotective effects of Korean Ginseng root extract in an experimental model of multiple sclerosis

Muhammet Oguzhan Dönmez, Göksel Şener, Tuğba Tunalı Akbay, Güzin Göksun Sivas et autres

Objective: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterised by demyelination. The aim of this study was to evaluate the neuroprotective effects of Korean ginseng root extract (KGE) using a cuprizone-induced demyelination model. Materials and Methods: …

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Polylactic Acid/Polyvinylpyrrolidone Scaffolds With Adipose Tissue-Derived Mesenchymal Stem Cells Enhance Nerve Regeneration in Rats

Toghrul Javadov, Semra Ünal, Asli Katmis, Mustafa Şakar et autres

The aim of this study was to investigate the treatment effect of an artificial nerve graft produced with polylactic acid (PLA) and polyvinylpyrrolidone (PVP) by electrospinning method, in combination with rat allogeneic adipose tissue-derived mesenchymal stem cells (rAT-MSCs), on axonal regeneration in …

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Biomimetic 3D bioprinted bilayer GelMA scaffolds for the delivery of BMP-2 and VEGF exogenous growth factors to promote vascularized bone regeneration in a calvarial defect model in vivo

Emıne Alarçın, Zeynep Püren Akgüner, Ayça Bal‐Öztürk, Gökçen Yaşayan et autres

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Embryotoxic effects of sunset yellow fcf in congenital neural tube defect formation in early-stage chick embryos: a histopathological study

Fatih Toprak, Dila Şener, Dilek Akakın, Ezgi Akar et autres

AIM: To investigate the embryotoxic effects of Sunset Yellow (SY) exposure on neural tube development in an experimental model of chicken embryos. MATERIAL AND METHODS: Sixty fertilized special pathogen-free (SPF) Leghorn genus chick embryos were used. Three experimental groups were determined, comprising …

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Effects of sodium nitrite on neural tube development in early-stage chick embryos

Ezgi Akar, Eylem Burcu Kahraman Özlü, Dila Şener, Dilek Akakın

ABSTRACT: AIM: To investigate the effects of sodium nitrite on spinal cord development in early-stage chick embryos. MATERIAL and METHODS: Sixty specific-pathogen-free fertile Leghorn-type eggs at Day 0 of incubation were used. Group 1 (control) received saline, Group 2 (low-dose) was administered …

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Estrogen Alleviates Oxidative Bowel Injury and Neuroinflammation in Necrotizing Enterocolitis

Kıvılcım Karadeniz Cerit, Türkan Koyuncuoğlu, Beyza Akcan, Nur Sena Çağatay et autres

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Intracerebroventricular administration of the exercise hormone irisin or acute strenuous exercise alleviates epileptic seizure-induced neuroinflammation and improves memory dysfunction in rats

Zarife Nigâr Özdemir Kumral, Tuğçe Akgün, Ceren Haşim, Ezgi Ulusoy et autres

BACKGROUND: Status epilepticus is a common and potentially life-threatening neurological emergency with a high risk for cognitive and neurobiological impairment. Our aim was to evaluate the neuroprotective effects of centrally administered irisin and acute exhausting exercise against oxidative brain injury and memory …

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Histological and biochemical effects of an ethanolic extract of Myrtus communis leaf on the pancreases of rats fed high fat diets

Gul Sinemcan Kabatas, Büşra Ertaş, Ali Şen, Göksel Şener et autres

(MC) leaves on the pancreases of rats fed with a high fat diet (HFD). Wistar albino rats were fed either with standard lab chow (Control group) or with a 45% fat diet (HFD and HFD+MC groups) for 4 months, with the MC …

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