Accès ouvert
2026
article
OpenAlex
Haiming L Kerr, Kora Krumm, Nornubari Myree, Artur Rybachok et autres
Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a, also known …
us
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Accès ouvert
2024
article
OpenAlex
Haiming L Kerr, Kora Krumm, Barbara Gallatin Anderson, Anthony J. Christiani et autres
Our study was to characterize sarcopenia in C57BL/6J mice using a clinically relevant definition to investigate the underlying molecular mechanisms. Aged male (23-32 months old) and female (27-28 months old) C57BL/6J mice were classified as non-, probable-, or sarcopenic based on assessments …
us
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Accès ouvert
2023
article
OpenAlex
Lucas Caeiro, Lindsey Jayne Anderson, Haiming M. Liu, Kora Krumm et autres
Abstract Disclosure: L. Caeiro: None. L.J. Anderson: None. H. Liu: None. K. Krumm: None. J.M. Garcia: None. Cancer-associated weight loss is a complex metabolic syndrome characterized by a loss of skeletal muscle mass and function. Insulin resistance is present in cancer but …
us
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Accès ouvert
2023
article
OpenAlex
Haiming L Kerr, Kora Krumm, Ian Lee, Barbara Gallatin Anderson et autres
BACKGROUND: Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects on muscle and fat. However, its clinical use is limited by the short half-life of active (acylated) ghrelin (~11 min in humans). EXT418 is a novel …
us
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Accès ouvert
2021
article
OpenAlex
Haiming M. Liu, Pu Zang, Ian Lee, Barbara Gallatin Anderson et autres
Abstract Background Ghrelin may ameliorate cancer cachexia (CC) by preventing anorexia, muscle, and fat loss. However, the mechanisms mediating these effects are not fully understood. This study characterizes the pathways involved in muscle mass and strength loss in the Lewis lung carcinoma …
us, cn
(code pays fourni par la source)
2019
conference-paper
OpenAlex
John C. Krumm, Kora Krumm
We show how to infer land use from mobility traces. Instead of using manual surveys or aerial image interpretation, our research shows how to use mobility traces to infer the number of businesses and residences in each cell of a grid on …
us
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