Janani Subramaniam

Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling in Pulmonary Hypertension: Implications for RNA-Based Diagnostics and Therapeutics

Janani Subramaniam, Venkata Soumith Jonnakuti, Scott D. Collum, Sandra Martineau et autres

Increased pulmonary vascular pressures due to vascular remodeling, elevated vascular resistance, and vasoconstriction characterize Pulmonary Arterial Hypertension (PAH). The narrowing of the pulmonary arteries and obstruction of blood flow increase the Right Ventricular (RV) afterload, forcing the RV to undergo structural and …

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Heartbreaking Ends: Unraveling the Significance of Alternative Polyadenylation in Right Ventricular Failure

Janani Subramaniam, Scott D. Collum, Andrea L. Frump, Venkata Soumith Jonnakuti et autres

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Obscurin regulates ankyrin macromolecular complex formation

Janani Subramaniam, Gokay Yamankurt, Shane R. Cunha

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Identification and characterization of self-association domains on small ankyrin 1 isoforms

Janani Subramaniam, Yang Pu, Michael J. McCarthy, Shane R. Cunha

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OBSCURIN MEDIATES ANKYRIN COMPLEX FORMATION IN THE HEART

Janani Subramaniam

Distinctly organized domains of receptors, ion channels, transporters, signaling molecules, cell adhesion molecules, and contractile proteins are crucial to cardiac function. Interactions between adaptor proteins such as ankyrins and cytoskeletal proteins such as obscurin play a pivotal role in organizing these functional …

Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction

Yong Li, Tanya A. Baldwin, Yan Wang, Janani Subramaniam et autres

Abstract Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in heart. But apart from potential IKs regulation, physiological roles for AC9 are unknown. We show that loss of AC9 in mice …

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Identification and characterization of two ankyrin-B isoforms in mammalian heart

Henry C. Wu, Gokay Yamankurt, Jialie Luo, Janani Subramaniam et autres

AIMS: Excitation-contraction coupling in cardiomyocytes requires the proper targeting and retention of membrane proteins to unique domains by adaptor proteins like ankyrin-B. While ankyrin-B has been shown to interact with a variety of membrane and structural proteins located at different subcellular domains …

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A PKM2 signature in the failing heart

Meredith L. Rees, Janani Subramaniam, Yuanteng Li, Dale J. Hamilton et autres

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Allow me to Explain! Mock-Juror Perceptions of Eyewitness Confidence Inflation

Amy Roach, Janani Subramaniam, Garrett L. Berman, Eric E. Jones

Effects of DNA and Explanations of Confidence Inflation on Mock-Juror Evaluations of Eyewitness Testimony

Garrett L. Berman, Eric E. Jones, Janani Subramaniam, Amy Roach et autres

Multimodality Evoked Potentials in Motor Neuron Disease

Janani Subramaniam, Con Yiannikas

We performed median and tibial nerve somatosensory evoked potentials (SEPs), pattern-shift visual evoked potentials (PSVEPs), and brain-stem auditory evoked potentials (BAEPs) on 27 patients with motor neuron disease (MND). Median and tibial nerve SEPs were abnormal in 8 (30%) of 27 and …

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