B. T. Mortensen

Vaginal Microbiota Transplantation (VMT) for treatment of vaginal dysbiosis without the use of antibiotics – A Double-Blinded Randomized Controlled Trial in healthy women with vaginal dysbiosis

Tine Wrønding, Kilian Vomstein, Kevin DeLong, Agnete Troen Lundgaard et autres

Abstract Here we describe the first double-blinded, randomized, placebo-controlled trial (RCT) on vaginal microbiota transplantation (VMT) without antibiotics in women with both symptomatic and asymptomatic vaginal dysbiosis. Forty-nine women were randomly assigned to VMT or placebo. The trial did not show a …

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O-280 Vaginal microbiota transplant (VMT) without antibiotic pretreatment reveals changes in vaginal microbiota and immune profile in women with asymptomatic dysbiosis – a randomized, placebo-controlled trial

Johan E. T. van Hylckama Vlieg, B. T. Mortensen, Eelke Bosma, Kelly DeLong et autres

Abstract Study question Investigate the safety of VMT and explore its effects on the vaginal microbiomes and local inflammation in healthy, asymptomatic volunteer women screened for vaginal dysbiosis Summary answer We demonstrate safety and engraftment of donor bacteria in 50% of recipients, …

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PO-1462 Patient-reported outcome measures after salvage radiotherapy for prostate cancer

Christine Vestergaard Madsen, M. Berg, Ali Zedan, B. T. Mortensen et autres

Clinical Experience with Bacteraemia in Patients with Leukaemia and Allied Neoplastic Diseases

B. T. Mortensen, Nikolaj Mortensen, Nis I. Nissen

134 bacteraemic episodes in 112 patients with leukaemia and allied disorders over a 5-year period were reviewed. The patients were divided, with respect to neoplastic disease, into 3 prognostic groups according to estimated periods of survival of years (group 1), months (group …

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Book Reviews

Sampat M. Singhvi, Anthony F. Heald, Eric C. Schreiber, H. H. Schassan et autres

Increased cellular hypoxia and reduced proliferation of both normal and leukaemic cells during progression of acute myeloid leukaemia in rats

Peter Østrup Jensen, B. T. Mortensen, R.J. Hodgkiss, Per Ole Iversen et autres

The microenvironmental changes in the bone marrow, spleen and liver during progression of the transplantable promyelocytic leukaemia in the Brown Norwegian rat (BNML) have been studied. We used flow cytometry to estimate cellular hypoxia and proliferation based on in vivo pulse-labelling with …

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S-Phase Induction by Interleukin-6 Followed by Chemotherapy in Patients with Chronic Lymphocytic Leukemia and Non-Hodgkin'S Lymphoma

P. de Nully, Marcus Diamant, Peter Østrup Jensen, Christian H. Geisler et autres

Interleukin-6 (IL-6) has in vitro demonstrated growth regulatory effects on tumor cells from patients with chronic lymphocytic leukemia (CLL) and lymphoma. The proliferation rate of these cells is usually very low and this is thought to be one of the reasons for …

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S-phase induction by interleukin-6 followed by chemotherapy in patients with refractory multiple myeloma

Peter de Nully Brown, Peter Østrup Jensen, Marcus Diamant, B. T. Mortensen et autres

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BEAM+autologous stem cell transplantation in malignant lymphoma: 100 consecutive transplants in a single centre. Efficacy, toxicity and engraftment in relation to stem‐cell source and previous treatment

Christian H. Geisler, Mads Hansen, Niels Smedegaard Andersen, Peter de Nully Brown et autres

One hundred consecutive patients with malignant lymphoma treated with high-dose chemotherapy and autologous stem cell transplantation, followed at least 1 yr post-transplant, are reported, 68 with non-Hodgkin's lymphoma and 32 with Hodgkin's disease. At transplant, 23 patients were in first remission, 69 …

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Changing bone marrow micro‐environment during development of acute myeloid leukaemia in rats

B. T. Mortensen, Peter Østrup Jensen, Niels Helledie, Per Ole Iversen et autres

The Brown Norwegian rat transplanted with promyelocytic leukaemic cells (BNML) has been used as a model for human acute myeloid leukaemia. We have previously shown that both the blood supply to the bone marrow and the metabolic rate decrease in relation to …

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Retroviral-Mediated Marker Gene Transfer in Hematopoiesis-Supportive Marrow Stromal Cells

Claude‐Eric Bulabois, Veronique Yerly-Motta, B. T. Mortensen, Philippe Fixe et autres

A Moloney-derived retrovirus containing both LacZ and NeoR genes (G1BgSVNa from Genetic Therapy, Inc.), was used to transduce human and murine bone marrow stromal cells. Different kinds of stromal cells that were able to support hematopoiesis were transduced by incubation for 24 …

Immediate bromodeoxyuridine labelling of unseparated human bone marrow cells ex vivo is superior to labelling after routine laboratory processing

Peter Østrup Jensen, B. T. Mortensen, Ib Jarle Christensen, Jacob Larsen

It is important to evaluate the proliferation of bone marrow cells in several disease conditions and during treatment of patients with for example cytokines. Labelling with bromodeoxyuridine (BrdUrd), immunocytochemical staining with anti-BrdUrd antibody and analysis by flow cytometry provides a reliable and …

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