Akira Yamauchi

Thioredoxin attenuates ischemia–reperfusion–induced pressure ulcer formation by enhancing HIF-1α/BNIP3-dependent mitophagy and suppressing MAPK/NF-κB signaling

Zhenlong Ji, Jueyi Zhang, Jionghao Sheng, Pan Li et autres

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Retinoic acid reduces oxidative stress and enhances migration-related signaling in vascular endothelial cells

Kei Miyano, Shuichiro Okamoto, Sae Mishima, Shigeko Fushimi et autres

Despite the important role of retinoic acid (RA) in vascular development, its effects on the behavior of endothelial cells (ECs) lining blood vessels remain incompletely understood. In this study, we investigated the effects of RA on oxidative stress and migration, both of …

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Comparison of the Anticancer Effects of a Complementary Peptide for Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3) With Conventional Anticancer Drugs in the Treatment of Oral Squamous Cell Carcinoma: A Pilot Study

Naoki Katase, Shin‐ichiro Nishimatsu, Akira Yamauchi, Shuichi Fujita

Introduction Oral squamous cell carcinoma (OSCC), which is the most common cancer type in head and neck cancers, remains a serious health problem because of its high mortality. Treatment of OSCC is mainly performed with a combination of surgery and anticancer agents. …

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Establishment of a method to evaluate the dynamics of highly chemotactic THP-1 cells during differentiation into monocyte-M1 macrophage-like cells

Shuichiro Okamoto, Kei Miyano, Yasumitsu Nishimura, Nahoko Tomonobu et autres

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Thioredoxin improves contact dermatitis through an anti-inflammatory mechanism different from glucocorticoids

Cuixue Wang, Jinquan Wang, Jiedong Zhou, Zhichao Gong et autres

Thioredoxin (TRX), a redox-regulatory protein of 12 kDa, plays an essential role in modulating oxidative stress and mediating inflammatory processes. In this study, we compared and analyzed the anti-inflammatory effects of topically applied recombinant human TRX (rhTRX), hydrocortisone, and their combination on …

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TXM-CB13 Improves the Intestinal Mucosal Barrier and Alleviates Colitis by Inhibiting the ROS/TXNIP/TRX/NLRP3 and TLR4/MyD88/NF-κB/NLRP3 Pathways

Ruijie Cao, Jinhui Zhou, Jiale Liu, Yaxuan Wang et autres

The activation of inflammasomes (NLRP3 and NLRP1) is central to the pathogenesis of inflammatory bowel disease (IBD). Here we examined the protective effects of a thioredoxin-mimetic peptide CB13 (TXM-CB13), known for its antioxidative stress and anti-inflammatory properties. We examined the effects of …

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NADPH oxidase subunit p22 : A marker of oxidase-dependent oxidative stress and target for stress suppression in nonphagocytic cells

Kei Miyano, Shuichiro Okamoto, Fumiya Ojima, Yasuhiro Takenouchi et autres

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Effect of administration and withdrawal of the sodium‐glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single‐arm study ( RESTORE ‐nephropathy study)

Ayako Shigeta, Masami Tanaka, Shu Meguro, Jiro Morimoto et autres

AIMS/INTRODUCTION: The mechanisms of the renoprotective effects of sodium-glucose cotransporter 2 inhibitors are unknown. This study aimed to explore the effect and mechanism of tofogliflozin on urinary albumin by administration, withdrawal, and re-administration. MATERIALS AND METHODS: Individuals with type 2 diabetes mellitus …

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An S100A8/A9 Neutralizing Antibody Potently Ameliorates Contact Hypersensitivity and Atopic Dermatitis Symptoms

Yuma Gohara, Rie Kinoshita, Nahoko Tomonobu, Yukiko Matsunaga et autres

Contact hypersensitivity and atopic dermatitis are pervasive inflammatory skin diseases with similar symptoms, and their global prevalence is steadily increasing. Many compounds and biotics have been developed to target molecules critical to the etiology or pathogenesis of contact hypersensitivity and atopic dermatitis. …

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Enhanced design of pCMViR-TSC plasmid vector for sustainably high cargo gene expression in mammalian cells

Masakiyo Sakaguchi, Rie Kinoshita, Nahoko Tomonobu, Yoshihiko Sakaguchi et autres

The first-generation pCMViR-TSC, implemented through the promoter sandwich rule, yields 10- to 100-fold higher gene expression than the standard plasmid used with the CMV (cytomegalovirus) or CAG promoter. However, the vector's shortcomings limit its utility to transient expression only, as it is …

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Editor’s Note: Targeting Activating Transcription Factor 3 by Galectin-9 Induces Apoptosis and Overcomes Various Types of Treatment Resistance in Chronic Myelogenous Leukemia

Junya Kuroda, Mio Yamamoto, Hisao Nagoshi, Tsutomu Kobayashi et autres

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Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis

Fan Jiang, Youyi Chen, Nahoko Tomonobu, Rie Kinoshita et autres

Background: Triple-negative breast cancer (TNBC) cells are a highly formidable cancer to treat. Nonetheless, by continued investigation into the molecular biology underlying the complex regulation of TNBC cell activity, vulnerabilities can be exposed as potential therapeutic targets at the molecular level. We …

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