Juris Jansons

Comparative Evaluation of Plant-Derived Virus-like Particles as Intratumoral Immunotherapy Agents

Anete Ogrina-Komarova, Zane Kalniņa, Rebeka Racina, Vilija Zeltina et autres

Background: Plant-derived virus-like particles (VLPs) are emerging nanoplatforms for local cancer immunotherapy, yet their relative performance across structurally distinct particles remains insufficiently defined. Methods: We performed a comparative benchmarking study of eleven plant-derived VLPs spanning diverse architectures and functional properties using an …

lv (code pays fourni par la source)

Multilevel Assessment of a Carbosilane Dendrimer−siRNA Nanoplatform: Cellular Compatibility, Blood−Brain Barrier Model Integrity, and Murine Model Biodistribution

Serafin Zawadzki, Elżbieta Okła, Paula Ortega, Francisco Javier de la Mata et autres

The tight regulation of bidirectional solute flux between the systemic circulation and neural tissue by the blood-brain barrier (BBB) remains a principal obstacle to effective pharmacotherapy of the central nervous system. In this study, we evaluate the biocompatibility and biodistribution of a …

pl, es, lv (code pays fourni par la source)

Copper metallodendrimers effectively deliver proapoptotic siRNA to human liver carcinoma HepG2 cells

Sylwia Michlewska, Marika Grodzicka, Marcin Hołota, Angela Dziedzic et autres

pl, lv, es (code pays fourni par la source)

Tiered Evaluation of Carbosilane Dendrimer–siRNA Nanoplatform from Single-Cell Biocompatibility to Blood-Brain Barrier Model Dynamics and Murine Alzheimer Model Behavior Assessment

Serafin Zawadzki, Elżbieta Okła, Sylwia Michlewska, Radosław Bednarek et autres

High Resolution Image Download MS PowerPoint Slide Blood–brain barrier (BBB) transport remains a primary constraint on achieving predictable central nervous system exposure for Alzheimer’s disease (AD) therapeutics, motivating the evaluation of delivery platforms with barrier-resolved and functionally relevant end points. We assessed …

pl, us, es, sk, ru, lv (code pays fourni par la source)

Inducing AIE in planar styrylpyridinium dyes through counterion exchange and liposomal encapsulation for live-cell imaging

Reinis Putralis, Aleksandra Gluščenko, Kristaps Krims-Dāvis, Ángel Buendía et autres

Aggregation-caused quenching (ACQ) significantly limits the performance of planar fluorescent probes in aqueous environments, thereby restricting their applicability in live-cell imaging. Although styrylpyridinium (SP) dyes possess favorable donor–π–acceptor architectures and attractive photophysical properties, their planar structure makes them prone to aggregation-induced fluorescence …

lv, es (code pays fourni par la source)

Complete Genomes of Human Papillomavirus Type 16 Viruses Isolated from Cases of Cervical Neoplasia and Squamous Cell Carcinomas Followed in Latvia in 2012–2024

Juris Jansons, Ņikita Zrelovs, Arta Spridzāne, Marija Nazarenko et autres

Background: Persistent high-risk human papillomavirus (hrHPV) infection causes over 99% of cervical precancers and cancers worldwide, with HPV genotype 16 (HPV16) responsible for 50% of the cases. Latvia ranks among the top EU countries for cervical cancer incidence and mortality. In the …

lv, hr, ua, se, us (code pays fourni par la source)

Genomic and experimental characterization of unique Antarctic temperate phage Perkons reveals multiple integrases and complex lysogenic dynamics in Psychrobacillus sp. L4

Ņikita Zrelovs, Karina Svanberga, Amanda Priedeslaipa, Juris Jansons et autres

BACKGROUND: Advances in culture-free microbial research have considerably expanded the known genomic diversity of prokaryotes and viruses associated with any imaginable environment. However, only a tiny fraction of this diversity has been obtained in culture, locking most of it to merely biological …

lv (code pays fourni par la source)

Investigation of Recombinantly Produced Endolysins Reveals a Modular Enzyme Shared by Several Enterobacteria Phages to Exhibit Broad‐Range Lytic Activity Against Different Orders of Gammaproteobacteria

Tatjana Kazaka, Ņikita Zrelovs, Ināra Akopjana, Jānis Bogans et autres

Endolysins or murein hydrolases are hydrolytic enzymes produced by bacteriophages to cleave the host's cell wall during the final stage of the lytic cycle. Whereas globular endolysins are composed of a single enzymatically active domain (EAD), modular endolysins have at least two …

lv (code pays fourni par la source)

Persistence of Viable Heterobasidion parviporum Inoculum in Norway Spruce Root Fragments in Drained Peat Soils

Dārta Kļaviņa, Lauma Silbauma, Astra Zaļuma, Natālija Burņeviča et autres

Roots infected by the forest pathogen Heterobasidion parviporum that remain in the soil after tree harvesting may serve as a source of inoculum for root infection of new generations of trees, thereby perpetuating outbreaks over time. As drained peat soils are evolutionary …

lv, it (code pays fourni par la source)

Online Conference “Chronic Viral Infections and Cancer, Openings for Vaccines and Cure” VIRCAN2024, Monitoring the Progress

Lība Sokolovska, Juris Jansons, Franco M. Buonaguro, Maria G. Isaguliants

Chronic viral infections and virus-induced cancers have been actively studied for decades, with many significant advancements in basic science, disease cure, treatment, and prevention. Yet, today, these infections and pathologies remain major contributors to morbidity and mortality worldwide. The international online conference …

lv, it, se (code pays fourni par la source)

New mouse model based on adenocarcinoma 4T1 cells expressing HPV16 E6 and E7 applied to assess the efficacy of therapeutic and prophylactic E6/E7-based HPV16 vaccines

Juris Jansons, Darya Avdoshina, Alesja Dudorova, Lība Sokolovska et autres

BACKGROUND: Development of immunotherapies and vaccines to treat HPV16-associated cancer requires reliable/effective small animal models. We developed such a model based on the murine mammary gland adenocarcinoma cells engineered to express HPV16 oncoproteins E6 and E7, and used it to assess the …

lv, es, us, se (code pays fourni par la source)

Chemotherapy (Etoposide)-Induced Intermingling of Heterochromatin and Euchromatin Compartments in Senescent PA-1 Embryonal Carcinoma Cells

Marc Bayer, Jaroslava Zajakina, Myriam Schäfer, Kristīne Salmiņa et autres

Background: Often, neoadjuvant therapy, which relies on the induction of double-strand breaks (DSBs), is used prior to surgery to shrink tumors by inducing cancer cell apoptosis. However, recent studies have suggested that this treatment may also induce a fluctuating state between senescence …

de, lv, ee (code pays fourni par la source)