Janardan D. Khandekar

ECOG-ACRIN E6293: Phase II Study of Raltitrexed in Advanced Colorectal Cancer

Chengwei Peng, P. Catalano, John Zalcberg, Ann D. Thor et autres

BACKGROUND: Inhibition of thymidylate synthase (TS) is a common mechanism in the treatment of colorectal cancer (CRC). 5-Fluorouracil is an indirect inhibitor of TS that is commonly used in CRC treatment regimens. Raltitrexed is a direct TS inhibitor that was hypothesized to …

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Operationalizing Next-Generation Sequencing in a Community-Based Academic Cancer Center: Workflow, Integration, and Impact

Gayathri Moorthy, Annette Sereika, Bruce Brockstein, Megan Parilla et autres

Background/Objectives: Prompt integration of molecular and clinical data into electronic medical records, with a sustainable workflow that supports clinicians in rendering genomics-guided care, is critical. We sought to expand the implementation of in-house NGS at our community-based academic cancer center to operationalize …

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Personalized medicine in a community health system: the NorthShore experience

Sean P. David, Henry M. Dunnenberger, Sarah Choi, Allison DePersia et autres

Genomic and personalized medicine implementation efforts have largely centered on specialty care in tertiary health systems. There are few examples of fully integrated care systems that span the healthcare continuum. In 2014, NorthShore University HealthSystem launched the Center for Personalized Medicine to …

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Cancer-associated thrombosis by cancer sites and inherited factors in a prospective population-based cohort

Zhuqing Shi, Jun Wei, Andrew S. Rifkin, Chi‐Hsiung Wang et autres

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Outcomes After Targeted Treatment Based on Somatic Tumor Genetic Testing for Women With Gynecologic Cancers

Sahana Somasegar, Claire Hoppenot, Kristine Kuchta, Annette Sereika et autres

(Abstracted from Gynecol Oncol 2021;163:220–228) Molecular tumor profiling with next-generation sequencing (NGS) has become increasingly used in the evaluation and treatment planning for primary and recurrent gynecologic cancer. This is driven by studies demonstrating that NGS-guided treatment results in longer time to …

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Clinical characteristics and viral load dynamics of COVID-19 in a mildly or moderately symptomatic outpatient sample

Amanda Caplan, Kelly W. Bates, Carla Brioni, Aileen Santos et autres

BACKGROUND: Studies of outpatients with mild or moderate COVID-19 are uncommon. We studied: 1) association of symptoms with reverse transcriptase polymerase chain reaction (RT-PCR) test results; and 2) association of initial RT-PCR cycle threshold (Ct) in relation to duration of RT-PCR positivity …

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Outcomes after targeted treatment based on somatic tumor genetic testing for women with gynecologic cancers

Sahana Somasegar, Claire Hoppenot, Kristine Kuchta, Annette Sereika et autres

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Association of Sickle Cell Trait with Risk and Mortality of COVID-19: Results from the United Kingdom Biobank

W. Kyle Resurreccion, Joseph Hulsizer, Zhuqing Shi, Jun Wei et autres

Sickle cell trait (SCT) carriers inherit one copy of the Glu6Val mutation in the hemoglobin gene and is particularly common in Black individuals (5-10%). Considering the roles of hemoglobin in immune responses and the higher risk for coronavirus disease (COVID-19) among Black …

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Three program enhancements to advance population genetic screening in a community health system during 2020

Peter J. Hulick, Jared Hammernik, Nadim Ilbawi, Janardan D. Khandekar et autres

Messenger RNA (mRNA) – A forgotten molecule; its past, present and future for therapeutics

Melin J. Khandekar, Janardan D. Khandekar

Association of Cancer with Risk and Mortality of COVID-19: Results from the UK Biobank

Zhuqing Shi, W. Kyle Resurreccion, Chi‐Hsiung Wang, Jun Wei et autres

Abstract Although cancer has been associated with COVID-19 risk and mortality in hospital-based studies, few population-based studies have been reported. Utilizing data from the UK Biobank (UKB), a population-based prospective cohort, we formally tested the association of over 44 different types of …

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Association of Sickle Cell Trait with Risk and Mortality of COVID-19: Results from the UK Biobank

W. Kyle Resurreccion, Zhuqing Shi, Jun Wei, Rong Na et autres

Abstract We tested the hypothesis that patients with sickle cell trait (SCT), a common condition in individuals of African descent, have increased risk and mortality for coronavirus disease (COVID-19) in the UK Biobank. By June 17, 2020, 1,550 of 7,668 (20%) tested …

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