Ingrida Olendraitė

RdRpCATCH: a unified resource for RNA virus discovery using viral RNA-dependent RNA polymerase profile Hidden Markov models

Dimitris Karapliafis, Uri Neri, Ingrida Olendraitė, Justine Charon et autres

Recent advances in large-scale sequence mining have expanded our knowledge of RNA virus diversity. Most genome mining approaches for detecting RNA viruses rely on identifying the conserved RNA-dependent RNA polymerase (RdRp) by scanning sequencing datasets with specialized profile Hidden Markov Models (pHMMs). …

nl, us, gb, fr, jp (code pays fourni par la source)

Consensus statement from the second RdRp Summit: towards a unified framework for RNA virus biology

Alexander G. Lucaci, Hisham Shaikh, Li Chong Chong, Rachid Tahzima et autres

RNA-dependent RNA polymerase, or RdRp, remains the central molecular hallmark of RNA viruses. It serves as both a universal anchor for virus detection and a critical target for understanding the functional and evolutionary properties of RNA viruses. Since the inaugural RdRp summit …

us, be, de, it, cz, jp, fr, fi, in, nl, gb, ar, ph, kr, rs, lt, si (code pays fourni par la source)

Consensus statement from the second RdRp Summit: towards a unified framework for RNA virus biology

Alexander Lucaci, Hisham Shaikh, Li Chuin Chong, Rachid Tahzima et autres

RNA-dependent RNA polymerase, or RdRp, remains the central molecular hallmark of RNA viruses. It serves as both a universal anchor for virus detection and a critical target for understanding the functional and evolutionary properties of RNA viruses. Since the inaugural RdRp summit …

be, de, fi, jp, in, nl, gb, br, ar, us, kr, fr, rs, lt (code pays fourni par la source)

Consensus statement from the second RdRp Summit: towards a unified framework for RNA virus biology

Alexander Lucaci, Hisham Shaikh, Li Chuin Chong, Rachid Tahzima et autres

RNA-dependent RNA polymerase, or RdRp, remains the central molecular hallmark of RNA viruses. It serves as both a universal anchor for virus detection and a critical target for understanding the functional and evolutionary properties of RNA viruses. Since the inaugural RdRp summit …

be, de, fi, jp, in, nl, gb, br, ar, us, kr, fr, rs, lt (code pays fourni par la source)

Author response of: Consensus statement from the second RdRp Summit: towards a unified framework for RNA virus biology. Round#1

Alexander G. Lucaci, Hisham M. Shaikh, Li Chuin Chong, Rachid Tahzima et autres

A recommendation of: Alexander G. Lucaci, Hisham M. Shaikh, Li Chuin Chong, Rachid Tahzima, Marco Forgia, Karima Ben Mansour, Shoichi Sakaguchi, So Nakagawa, Xin Hou, Tatiana Demina, Fhilmar Raj Jayaraj Mallika, Anne Kupczok, Spyros Lytras, Humberto Debat, Justine Charon, Michael Louie Urzo, …

Multi-omics Integration Implicates RAC/RHO GTPase Cycling and Lipid Metabolic Disruptions in Vascular Cognitive Impairment and Dementia Pathogenesis

Milda Milčiūtė, Sangeetha Vishweswaraiah, Nadia Ashrafi, Romana Mimi et autres

Background: Vascular cognitive impairment (VCI) is a major contributor to dementia (20–40% of cases), yet its molecular mechanisms are largely unknown. Traditional single-omics studies, such as those using metabolomics to track biochemical changes, fail to capture the complex, interactive processes driving VCI …

lt, us, tr (code pays fourni par la source)

Anthropozoonotic spillovers reveal sustained long-term cryptic circulation of SARS-CoV-2 within and between Lithuanian mink farms

Martynas Smičius, Ingrida Olendraitė, Jonas Bačelis, Aistis Šimaitis et autres

Main and supplementary figures, BEAST XML (with sequences removed, per GISAID’s user agreement), trees (posterior and MCC), and log files, data on mink and human SARS-CoV-2 case data, GISAID acknowledgment tables and accessions used, as well as code to analyse and visualise …

lt, cz, gb, ru, dk, nl (code pays fourni par la source)

RdRpCATCH: A unified resource for RNA virus discovery using viral RNA-dependent RNA polymerase profile Hidden Markov models

Dimitris Karapliafis, Uri Neri, Ingrida Olendraitė, Justine Charon et autres

Recent advances in large-scale sequence mining have expanded our knowledge of RNA virus diversity. Most genome mining approaches for detecting RNA viruses that encode RNA-dependent RNA polymerase (RdRp) rely on identifying this conserved protein by employing profile Hidden Markov Models (pHMMs) to …

nl, us, gb, fr, jp (code pays fourni par la source)

Anthropozoonotic spillovers reveal sustained long-term cryptic circulation of SARS-CoV-2 within and between Lithuanian mink farms

Martynas Smičius, Ingrida Olendraitė, Jonas Bačelis, Aistis Šimaitis et autres

Abstract Several studies have documented reverse zoonotic transmission of SARS-CoV-2, including in farmed mink which are susceptible to human respiratory viruses and are known for serving as a reservoir capable of generating new virus variants in densely populated farms. Here, we present …

lt, gb, dk, nl, sk (code pays fourni par la source)

Integrative Multi‐Omics Analysis Reveals Rac GTPase Pathway Dysregulation Driving Lipid Metabolic Alterations in Vascular Cognitive Impairment

Sangeetha Vishweswaraiah, Nadia Ashrafi, Romana Ashrafi Mimi, Nazia Saiyed et autres

BACKGROUND: Vascular cognitive impairment (VCI) encompasses a spectrum of cognitive disorders linked to vascular dysfunction, with underlying mechanisms remaining poorly understood. Traditional single-omics approaches often fail to capture the complex biological networks driving VCI, necessitating integrative multi-omics methodologies. METHOD: Brodmann area 7 …

us, tr, lt (code pays fourni par la source)

Anthropozoonotic spillovers reveal sustained long-term cryptic circulation of SARS-CoV-2 within and between Lithuanian mink farms

Martynas Smičius, Ingrida Olendraitė, Jonas Bačelis, Aistis Šimaitis et autres

Several studies have documented reverse zoonotic transmission of SARS-CoV-2, including in farmed mink which are susceptible to human respiratory viruses and are known for serving as a reservoir capable of generating new virus variants in densely populated farms. Here, we present the …

lt, gb, dk, nl (code pays fourni par la source)

Automated computational platform for interpretation of multi-omics data reveals novel disease biomarkers

Tadas Bareikis, Algimantas Kriščiūnas, Ingrida Olendraitė, Karolina Makovskytė et autres

Introduction: This study presents an automated computational platform for multi-omics integration and analysis through several case studies, incorporating transcriptomics, epigenetics, and metabolomics. By leveraging robust statistical modeling, bioinformatics and machine learning, the platform enables comprehensive understanding and novel insights into disease physiology. …