Mar Royuela

Differential expression of ferroptosis markers, circadian regulators, KLOTHO, and classical tumor suppressors in colorectal cancer according to tumor stage: Influence of age, anatomical location, and correlation patterns.

Miguel A. Sáez, Cielo García Montero, Oscar Fraile‐Μartinez, Ana Minaya‐Bravo et autres

Colorectal cancer (CRC) is a leading cause of cancer-related mortality, with an incidence projected to rise significantly worldwide. While TNM staging remains the cornerstone of prognosis and treatment decisions, additional biomarkers are needed to enhance predictive accuracy and therapeutic targeting. Ferroptosis, an …

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Histone Acetyl Transferase 1 Is Overexpressed in Poor Prognosis, High-grade Meningeal and Glial Brain Cancers: Immunohistochemical and Aptahistochemical Study

Sandra Bargiela-Cuevas, María Marin, María Gabaldon-Ojeda, José Ignacio Klett-Mingo et autres

Primary malignancies of the central nervous system account for 2% of all cancers in adults and almost 15% in children under 15 years of age. The prognosis of brain anaplastic cancers and glioblastomas remains extremely poor, with devastating survival expectative, and new …

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Características y tratamiento de los pacientes nonagenarios con enfermedad vascular ingresados en los servicios de medicina interna. Registro NONAVASC-2

A. Espiño-Álvarez, M. Vargas-Tirado, Mar Royuela, Aída Gil‐Díaz et autres

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Chronic Venous Disease during Pregnancy Is Related to Inflammation of the Umbilical Cord: Role of Allograft Inflammatory Factor 1 (AIF-1) and Interleukins 10 (IL-10), IL-12 and IL-18

Lara Sánchez‐Trujillo, Oscar Fraile‐Μartinez, Cielo García Montero, Luis M. García-Puente et autres

Chronic venous disease (CVD) is a common condition that affects the veins in the lower limbs, resulting in a variety of symptoms, such as swelling, pain, and varicose veins (VVs). The plenty hormonal, hemodynamic and mechanical changes occurred in pregnancy make women …

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Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease

Miguel Angel Ortega, Diego De León-Oliva, Cielo García Montero, Oscar Fraile‐Μartinez et autres

Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation …

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TGF-β/PI3K/AKT/mTOR/NF-kB pathway. Clinicopathological features in prostate cancer

Norelia Torrealba, Raúl Vera, Benito Fraile, Pilar Martínez-Onsurbe et autres

Prostate cancer is one of the most common cancers in the male population. The objective of this investigation was to study the relationship of components of transforming growth factor-B (TGF-β)/phosphoinositide-3-kinases (PI3K)/AKT/mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kB) transduction pathway with …

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Homeostasis: apoptosis and cell cycle in normal and pathological prostate

Norelia Torrealba, Gonzalo Rodríguez‐Berriguete, Raúl Vera, Benito Fraile et autres

Prostatic diseases such as hyperplasia and cancer are a consequence of glandular aging due to the loss of homeostasis. Glandular homeostasis is guaranteed by the delicate balance between production and cell death. Both cell renewal and apoptosis are part of this delicate …

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PI3K pathway and Bcl-2 family. Clinicopathological features in prostate cancer

Norelia Torrealba, Gonzalo Rodríguez‐Berriguete, Benito Fraile, Gabriel Olmedilla et autres

The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathways and Bcl-2 family play a central role in prostate cancer (PC). The aim was to determine influence in the biochemical progression in PC. To evaluate the association between clinic pathological and immunohistochemical variables, Spearman's test was performed. …

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Immune profiling of human prostate epithelial cells determined by expression of p38/TRAF‐6/ERK MAP kinases pathways

Yosra Bouraoui, Mongia Achour, Mar Royuela, Ridha Oueslati

The aim of the present work was to study the immune profiling of prostate epithelial cells by the expression of ASK-1/p38 and Raf-1/ERK MAP Kinases signaling pathways mediated by TRAF-6. Immunohistochemical and Western blot analyses for TRAF-6, ASK-1, MEK-6, p38, Raf-1, MEK-1, …

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Immunocytochemically determined regulatory proteins, troponin, calponin and caldesmon, may occur together in the musculature of a Gordian worm (Ecdysozoa, Cycloneuralia, Nematomorpha)

Victor Benno Meyer‐Rochow, Mar Royuela

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Xyloglucan, Hibiscus and Propolis for the Prevention of Urinary Tract Infections: Results of in vitro Studies

Benito Fraile, Javier Alcover, Mar Royuela, David Rodrı́guez et autres

AIM: To assess the properties of a medical device containing xyloglucan, propolis and hibiscus to create a bioprotective barrier to avoid the contact of uropathogenic Escherichia coli strains on cell walls in models of intestinal (CacoGoblet) and uroepithelial (RWPE-1) cells (derived from …

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Expression of several cytokines in prostate cancer: Correlation with clinical variables of patients. Relationship with biochemical progression of the malignance

Norelia Torrealba, Gonzalo Rodríguez‐Berriguete, Benito Fraile, Gabriel Olmedilla et autres

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