Shinji Sawai

WCN26-3538 FIBROBLAST-DERIVED CCN1 IS INVOLVED IN THE FIBROSIS MECHANISM DURING THE CHRONIC PHASE AFTER KIDNEY INJURY

Shinji Sawai, Tomohiro Nakata, Atsushi Minamida, Keiichi Tamagaki et autres

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Repeated low-dose streptozotocin induces latent renal proximal tubular injury independently of blood glucose

Masashi Nakamura, Kunihiro Nakai, Erika Tsujinaka-Sawai, Ryo Kurose et autres

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Toll like receptor 2 mediated exacerbation of sepsis associated acute kidney injury by renal congestion in mice

Itaru Nakamura, Minato Umehara, Aya Yagi-Tomita, Satomi Yamamoto et autres

Renal congestion is a key factor in renal dysfunction associated with heart failure. We previously reported that renal congestion worsened renal ischemia-reperfusion in a murine model. However, its impact on sepsis-associated acute kidney injury (SA-AKI), the leading cause of AKI, remains unclear. …

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Injured tubule derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis

Atsushi Minamida, Tomohiro Nakata, Ryo Kurose, Shinji Sawai et autres

Epidemiological studies show that heart failure often leads to kidney dysfunction, known as cardio-renal syndrome (CRS). Elevated central venous pressure, rather than low cardiac output, strongly correlates with worsening renal function and is increasingly recognized as the cause of CRS. However, the …

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Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury

Tomohiro Nakata, Yuhei Kirita, Minato Umehara, Masashi Nakamura et autres

Humoral factors that prompt fibroblasts to migrate to an injury site at an appropriate time point are deemed indispensable for repair after kidney injury. We herein demonstrated the pivotal roles of injured tubule-derived cellular communication network factor 1 (CCN1) in the mobilization …

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Renal granulomatous arteritis induced by immune checkpoint inhibitors

Nana Ishimura, Yayoi Shiotsu, Naoko Masuzawa, Shinji Sawai et autres

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Antibody-mediated pure red cell aplasia related with epoetin-beta pegol (C.E.R.A.) as an erythropoietic agent: case report of a dialysis patient

Yasuki Shingu, Tomohiro Nakata, Shinji Sawai, Hisaya Tanaka et autres

BACKGROUND: Erythropoietin-stimulating agents (ESAs) are used to treat anemia in patients with chronic kidney disease, enabling maintenance of stable hemoglobin levels and eliminating the need for multiple transfusions. Epoetin-beta pegol (C.E.R.A.) is a continuous erythropoietin receptor activator created by integrating a large …

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