Marta Oknińska

Infarctsize-AI: an efficient preclinical infarct size image analysis tool

Csenger Kovácsházi, Dóra Kapui, Bennet Y. Weber, Tamás G. Gergely et autres

hu, sg, us, gb, lv, ru, pl, ps, es, de, cz, nl, gr, at (code pays fourni par la source)

Raw data for the article: Increased superoxide anion generation and upregulation of eNOS gene expression in cerebral microvessels during experimental hypoosmolar hyponatremia

Marta Aleksandrowicz, Kinga Czubowicz, Przemysław Wencel, Mariusz Popek et autres

The aim of this study was to investigate the effect of acute and chronic hyponatremia induced by vasopressin and its synthetic analogue desmopressin on the level of oxidative stress and eNOS gene expression in cerebral microvessels. The experiments were conducted on 105 …

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Infarctsize-AI: an efficient infarct size image analysis tool for small rodent myocardial infarction studies

Csenger Kovácsházi, Dóra Kapui, Bennet Y. Weber, T Gergely et autres

Abstract Background Myocardial infarct size (IS) is the gold standard end-point in shorth-term studies on cardioprotection. However, IS quantification in rodent models with standard Evans Blue and 2,3,5-triphenyltetrazolium chloride (TTC) staining is time-consuming and prone to inter-observer variance. Therefore, we aimed to …

hu, sg, lv, pl, gb, es, de, nl, gr, at (code pays fourni par la source)

Correction: IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning

Sauri Hernández‐Reséndiz, Reinis Vilšķe̅rsts, David Aluja, Ioanna Andreadou et autres

In the original article co-authors Gábor B. Brenner, András Makkos, Tamás G. Gergely and Nabil V. Sayour were missing from the author group due to an administrative error on the authors’ part. The authors contributed significantly to the study by generating all …

sg, lv, es, gr, hu, ie, at, gb, ch, Afrique du Sud, ca, pl, it, nl (code pays fourni par la source)

IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning

Sauri Hernández‐Reséndiz, Reinis Vilšķe̅rsts, David Aluja, Ioanna Andreadou et autres

Although many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of acute myocardial ischemia/reperfusion injury (IRI), their clinical translation to patient benefit has been largely disappointing. A major factor is the lack of rigor and reproducibility …

sg, lv, es, gr, hu, ie, at, gb, ch, Afrique du Sud, ca, pl, it, nl (code pays fourni par la source)

Myo‐inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline‐induced pulmonary hypertension in the rat

Marta Oknińska, Aleksandra Paterek, Małgorzata Grzanka, Karolina Zajda et autres

BACKGROUND AND PURPOSE: Pulmonary hypertension (PH) results from pulmonary vasculopathy, initially leading to a compensatory right ventricular (RV) hypertrophy, and eventually to RV failure. Hypoxia can trigger both pulmonary vasculopathy and RV failure. Therefore, we tested if myo-inositol trispyrophosphate (ITPP), which facilitates …

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Sex- and age-dependent susceptibility to ventricular arrhythmias in the rat heart ex vivo

Marta Oknińska, Monika Duda, E. Czarnowska, Joanna B. Bierła et autres

Abstract The incidence of life-threatening ventricular arrhythmias, the most common cause of sudden cardiac death (SCD), depends largely on the arrhythmic substrate that develops in the myocardium during the aging process. There is a large deficit of comparative studies on the development …

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Sex- and age-dependent susceptibility to ventricular arrhythmias in the rat heart ex vivo.

Marta Oknińska, Monika Duda, E. Czarnowska, Joanna B. Bierła et autres

Abstract Background The incidence of life-threatening ventricular arrhythmias, the most common cause of sudden cardiac death (SCD), depends largely on the arrhythmic substrate that develops in the myocardium during the aging process. There is a huge deficit of comparative studies on the …

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Role of Oxygen Starvation in Right Ventricular Decompensation and Failure in Pulmonary Arterial Hypertension

Marta Oknińska, Karolina Zajda, Zuzanna Zambrowska, Małgorzata Grzanka et autres

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Arginase Inhibition Mitigates Bortezomib-Exacerbated Cardiotoxicity in Multiple Myeloma

Aleksandra Paterek, Marta Oknińska, Zofia Pilch, Anna Sosnowska et autres

BACKGROUND: Multiple myeloma (MM) is associated with increased cardiovascular morbidity and mortality, while MM therapies also result in adverse cardiac effects. Endothelial dysfunction and impaired nitric oxide (NO) pathway is their possible mediator. OBJECTIVE: Since MM is associated with increased arginase expression, …

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Right Ventricle Remodelling in Left-Sided Heart Failure in Rats: The Role of Calcium Signalling

Aleksandra Paterek, Marta Oknińska, Michał Ma̧czewski, Urszula Mackiewicz

Right ventricular dysfunction (RVD) can follow primary pulmonary diseases, but the most common cause of its development is left-sided heart failure (HF). RVD is associated with HF progression, increased risk of death and hospitalisation. The mechanism of right ventricle (RV) remodelling leading …

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Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity

Kavita Ramji, Tomasz M. Grzywa, Anna Sosnowska, Aleksandra Paterek et autres

Multiple myeloma (MM) remains an incurable malignancy of plasma cells despite constantly evolving therapeutic approaches including various types of immunotherapy. Increased arginase activity has been associated with potent suppression of T-cell immune responses in different types of cancer. Here, we investigated the …

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