Kikuko Amagase

Sul992 COLCHICINE REDUCES LIVER FIBROGENESIS BY MODULATING INFLAMMATORY AND HEPATIC STELLATE CELL RESPONSES

Honoka Masuda, Yuuki Otsuka, Chihiro Kubota, Chisato Ooki et autres

Sul992 COLCHICINE REDUCES LIVER FIBROGENESIS BY MODULATING INFLAMMATORY AND HEPATIC STELLATE CELL RESPONSES

Honoka Masuda, Yuuki Otsuka, Chihiro Kubota, Chisato Ooki et autres

Ring-opening simplification of thiazolyl–pyrazoline–triazole hybrids: synthesis, SAR and antifolate mechanism against Leishmania major

Esraa A. Abdelsalam, Wagdy M. Eldehna, Sherif F. Hammad, Nicolas Masurier et autres

= 305.6 and 585.6 μM; SI = 323 and 655, respectively), validating this open hydrazone-linked thiazole-triazole scaffold as a promising platform for antileishmanial drug development. Finally, molecular docking studies of compounds 8d and 8h within the PTR1 active site were performed to …

Égypte, fr, jp, bh (code pays fourni par la source)

An exploration of potent antileishmanial agents derived from quinoline–thiazole and thiadiazole hybrids, targeting DHFR-TS and PTR1: design, synthesis, and computational analyses

Huda R. M. Rashdan, Adnan A. Bekhit, Veronika Furlan, Kikuko Amagase et autres

an antifolate mechanism, selectively inhibiting key enzymes in the folate pathway: pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS). Molecular docking and 100 ns molecular dynamics (MD) simulations demonstrated that the quinoline core occupies a hydrophobic pocket formed by residues Phe113, …

Égypte, bh, si, jp, gb, iq (code pays fourni par la source)

Zinc transporter dynamics in the pathogenesis of 2,4,6-trinitrobenzenesulfonic acid/ethanol-induced ileitis in mice.

Yuuki Otsuka, W Shinohara, Kazumi Iwata, Kikuko Amagase

expression in the ileum significantly decreased at 24 h but recovered slightly at 48 h, coinciding with re-epithelialization. Overall, the pathogenesis of TNBS/ethanol-induced ileitis involves dynamic changes in zinc transporters.

jp (code pays fourni par la source)

Translational pharmacokinetic-pharmacodynamic/toxicodynamic (PK-PD/TD) modeling of antitumor effects and peripheral neuropathy in gemcitabine and NAB-paclitaxel chemotherapy

Shinji Kobuchi, Atsuko Morita, Shizuka Jonan, Kikuko Amagase et autres

jp (code pays fourni par la source)

Circulating tumor cells kinetics after short- and long-term folfirinox and GEM/NAB-PTX chemotherapy in xenograft mouse models of human pancreatic cancer

Yukako Ιtο, Shinji Kobuchi, Yume Matsunaga, Shoma Yoshioka et autres

jp (code pays fourni par la source)

Ciliary Motility Decreased by a CO2/HCO3−-Free Solution in Ciliated Human Nasal Epithelial Cells Having a pH Elevated by Carbonic Anhydrase IV

Shota Okamoto, Makoto Yasuda, Kotoku Kawaguchi, Kasane Yasuoka et autres

An application of CO2/HCO3−-free solution (Zero-CO2) did not increase intracellular pH (pHi) in ciliated human nasal epithelial cells (c-hNECs), leading to no increase in frequency (CBF) or amplitude (CBA) of the ciliary beating. This study demonstrated that the pHi of c-hNECs expressing …

jp (code pays fourni par la source)

Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation

Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Misaki Matsumoto et autres

Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this study, we attempted to identify drug candidates to inactivate HSCs and found that several proteasome …

jp (code pays fourni par la source)

A decrease in ciliary motility induced by a CO2/HCO3--free solution characteristic of ciliated human nasal epithelial cells: acceleration of HCO3- transport by carbonic anhydrase IV

Makoto Yasuda, Kotoku Kawaguchi, Kasane Yasuoka, Yumi Kikukawa et autres

An application of CO2/HCO3--free solution (Zero-CO2) did not increase intracellular pH (pHi) in ciliated human nasal epithelial cells (c-hNECs), leading to no increase in the beating frequency (CBF) or bend distance (CBD, an index of amplitude). This study demonstrated that the pHi …

jp (code pays fourni par la source)

Carfilzomib Shows Therapeutic Potential for Reduction of Liver Fibrosis by Targeting Hepatic Stellate Cell Activation

Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Kazumi Iwata et autres

jp (code pays fourni par la source)

Sa1191 INVESTIGATING THE EFFECTS OF STATIN DRUGS ON CHRONIC ULCERATIVE COLITIS-INDUCED COLORECTAL FIBROSIS

Yuuki Otsuka, Reiichiro Sasaki, Kikuko Amagase