Accès ouvert
2025
article
OpenAlex
Belén Custodio, Rosa Montesinos, José Carlos Huilca, Diego Bustamante‐Paytan et autres
BACKGROUND: Community Advisory Boards (CABs) are formal groups of community members who collaborate with research teams. The establishment of CABs have been shown to be an effective strategy for enhancing community engagement in research. This study aims to illustrate the process of …
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Accès ouvert
2025
article
OpenAlex
Belén Custodio, Rosa Montesinos, Maria Eugenia Godoy, José Carlos Huilca et autres
BACKGROUND: Recruitment for dementia research remains a persistent challenge, particularly when trying to reach underrepresented groups such as Latin Americans with traditional enrolment strategies. This abstract describes the experience of the Research Department at the Instituto Peruano de Neurociencias in employing culturally …
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Accès ouvert
2025
article
OpenAlex
Belén Custodio, Rosa Montesinos, José Carlos Huilca, Katherine Agüero‐Flores et autres
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease affecting millions of people worldwide. This situation is particularly severe in low- and middle-income countries, where numerous barriers hinder timely diagnosis and treatment. To date, two monoclonal anti-amyloid have shown positive results in phase …
pe
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Accès ouvert
2025
article
OpenAlex
Gregory Brown, Diego Bustamante‐Paytan, José Carlos Huilca, Maria Fe Albujar‐Pereira et autres
BACKGROUND: Dementia is rising globally, with a significant impact in Latin America. Low education has been associated with reduced cognitive reserve and structural brain changes, increasing vulnerability to neurodegeneration. However, the factors influencing these brain alterations remain an emerging area of research. …
us, pe
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Accès ouvert
2025
article
OpenAlex
Diego Bustamante‐Paytan, José Carlos Huilca, Gustav Brown, Maria Fe Albujar‐Pereira et autres
BACKGROUND: Primary progressive aphasias (PPA) are a group of neurodegenerative syndromes primarily characterized by the progressive loss of language. Despite established diagnostic criteria, identification can be challenging, especially in regions with limited resources and few studies, such as Latin America. This study …
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Accès ouvert
2025
article
OpenAlex
Nilton Custodio, Marco Málaga, Diego Bustamante‐Paytan, José Carlos Huilca et autres
BACKGROUND: Dementia with Lewy Bodies (DLB) is a specific type of dementia associated with the accumulation of alpha-synuclein protein in the brain. The disease often presents heterogeneously in its early stages, and little is known about how this variability affects its progression. …
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Accès ouvert
2025
article
OpenAlex
Gustav Brown, Diego Bustamante‐Paytan, Maria Fe Albujar‐Pereira, José Carlos Huilca et autres
Abstract Background The diagnosis of Alzheimer's disease requires standardized neuropsychological assessments, adapted and validated for each community. Demographically adjusted normative data are critical for accurate evaluations. The Uniform Data Set (UDS) neuropsychological battery, widely used in the National Alzheimer's Coordinating Center (NACC), …
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Accès ouvert
2025
article
OpenAlex
C. Gascón Muñoz, Nilton Custodio, Rosa Montesinos, Belén Custodio et autres
BACKGROUND: Functional impairment (FI) is a key component in diagnosing and monitoring the severity of neurodegenerative dementia (ND). It manifests in several dimensions, such as everyday cognition, mobility, social functioning, and activities of daily living (ADLs). However, traditional assessments have primarily focused …
cl, pe, ar
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Accès ouvert
2025
article
OpenAlex
Gregory Brown, Diego Bustamante‐Paytan, Maria Fe Albujar‐Pereira, José Carlos Huilca et autres
BACKGROUND: Instrumental activities of daily living (IADL) involve activities with higher cognitive demands, such as meal preparation, shopping, home maintenance, and financial management. IADL disturbances often emerge in early disease stages, affected by cognitive deficits regardless of dementia diagnosis. There are distinct …
us, pe
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Accès ouvert
2025
article
OpenAlex
Gregory Brown, Diego Bustamante‐Paytan, Maria Fe Albujar‐Pereira, José Carlos Huilca et autres
BACKGROUND: Instrumental Activities of Daily Living (IADL) are key indicators of functional decline in dementia, but culturally adapted tools for Latin America are scarce. The Amsterdam IADL Questionnaire Short Version (A-IADL-Q-SV) has shown strong psychometric properties globally but has not been validated …
us, pe
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Accès ouvert
2025
article
OpenAlex
Diego Bustamante‐Paytan, José Carlos Huilca, Gregory Brown, Maria Fe Albujar‐Pereira et autres
BACKGROUND: Primary progressive aphasias (PPA) are characterized by a progressive deterioration of language. Despite the establishment of international criteria in 2011 defining three variants (semantic, nonfluent, and logopenic), these variants can present overlapping symptoms, making their identification and differentiation challenging. This study …
pe, us
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Accès ouvert
2025
article
OpenAlex
Graciet Verastegui, Diego Bustamante‐Paytan, Rosa Montesinos, Nilton Custodio et autres
In the coming decades, the number of dementia cases is projected to increase worldwide. This public health issue will significantly impact low- and middle-income countries, such as those in Latin America, due to their aging populations. Proper diagnosis and identification of these …
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